Protein Alignment jar and myo3b

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_073768512.1
• Gene: myo3b / 564573
• ZFINID: ZDB-GENE-070706-2
• Length: 1333
• Species: Danio rerio
• Alignment Length: 1022
• Identity: 290/1022 - (28%)
• Similarity: 466/1022 - (45%)
• Gaps: 193/1022 - (18%)

  Fly    49 IHSSCDGPQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIK 113
            |..||    ..||...|.||:|.|.:.:|:.||...:|||||.:||||:||::.: .:|:|...|
Zfish   377 IIESC----PDDDLVNLELLDEETIIAHLQKRYQDLQIYTYVGDILIALNPFQNL-SIYSPQFSK 436

  Fly   114 KYNGRSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY-SHDSAGP 177
            .|:|......|||:||.||.|.:.|......|.||:|||||||||||...::::|.: ...:...
Zfish   437 LYHGMKRSTNPPHIFATADAAYQSMVTLCKDQCIIISGESGAGKTESAHLIVQHLTFLGKANNRT 501

  Fly   178 IETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEE 242
            :..|||..||::||||||.|..|:|||||||::|:.:.....|:|..||.|||||||:..|:..|
Zfish   502 LREKILQVNPLVEAFGNACTAINDNSSRFGKYLEMKFTPTGAVMGAKISEYLLEKSRVIKQATGE 566

  Fly   243 RNYHVFYMLLAGAPQQ--LRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPL 305
            :|:|:||.:.||...|  || |..|......||:. |    .|.|..|.|..|:..|
Zfish   567 KNFHIFYYIYAGLYHQDNLR-KYKLPNKTAPRYID-C----VNGKVMQDIISSKLYK-------- 617

  Fly   306 KDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAF-----------EEIPDDVR 359
                    :.|..:......:|.::.|...:|.::||:|:.|||.|           .|:|:
Zfish   618 --------EQFDAIQDCFRIIGFTEEEVNSVYRILAAILNTGNIEFASASSQHQSDKSEVPN--- 671

  Fly   360 GGCQVSEASEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALA 424
                 |||.:.:    :.||.:...||:.||.|..:.::|    .|:|... .:.:|:..|||::
Zfish   672 -----SEALDNA----AALLSIGSEELQEALTSHCVVTRG----ETIIRTN-TVDKATVVRDAMS 722

  Fly   425 KAIYSRLFDRIVGLIN------QSIPFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKF 483
            ||:|.|||..||..||      .:|....|...:|:|||.|||.|..|||||.|||..||::|.:
Zfish   723 KALYGRLFSWIVNRINALLQPDTNICAAESGMNVGILDIFGFENFKKNSFEQLCINIANEQIQFY 787

  Fly   484 FNDNILKNEQELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVH 548
            ||.:|...||..|:.||::|..:.:.||:.|:::...|..|:.:||||||:.|:.:......:..
Zfish   788 FNQHIFALEQIEYQSEGVDVSLVEYEDNRPILDMFLQKPMGLLSLLDEESRFPQATDQTLVDKFQ 852

  Fly   549 KSWANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECD 613
            .:..|.| ..:|:          |.|..|.::|:||.|.||...|:|||.|.|.|.:..:::..:
Zfish   853 DNLRNKY-FWIPK----------RVELCFGIQHYAGQVLYNVSGFLEKNRDTLPADIVVVLRTSE 906

  Fly   614 NPLLQTLFPS-----GSSTSVRGKLNFIS------------------------------------ 637
            |.|||.||.|     |:..:.|.::...|
Zfish   907 NRLLQQLFSSPLTKTGNLATSRARVTAASRSLPPQLNSGRNKSPKYLLKVDTMEMMRHPEETTNM 971

  Fly   638 ----VGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQ---FEGSLALAQLKCSGTISVLEL 695
                |.|.|:..|.:|:.|:.....:|:||||||.   |||   |.....:.||:.:|.:..:.:
Zfish   972 RRQTVASYFRYSLMDLLSKMVVGTPHFVRCIKPND---DRQALRFNKERVMVQLRYTGILETVNI 1033

  Fly   696 MEHGYPSRVLFADLYSMYKSVLPPELVSLPARTFCEAMFQSLNLSAKDFKF-----GITKVFFRP 755
            ...||..|:|..:..:.|      ..::..|....|...::..:..:..|.     |.||||.:.
Zfish  1034 RRQGYSHRILIQEFVNRY------YYLAFRAHQMPEGSKENAIIILQKAKLDYWVVGNTKVFLKY 1092

  Fly   756 GKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRW----VKSALGALCV------------IKLRNR 804
            ....:.:.::|.....::.:.|..|.||...|:    .|...||:.:            :||..|
Zfish  1093 YHVEQLNLMLREVIARVVLMQAYTKGWLGARRYRREREKRRNGAVVIQSAWRGHVARQNLKLIKR 1157

  Fly   805 IIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNT-----LKTIEIASGLKMGREEIIS 864
              .|.:..:..|.:.||:..||.::...|..|:.:..|::|     .|.:.:::...:|..
Zfish  1158 --EREQAAVQIQSVYRGYRVRKDYKQSRQWTGQPSSKRSSTNHSPDEKVVSVSADSGIGSS---- 1216

  Fly   865 GVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQ 929
                     |.::.|       |.::.||.....::.... |:.|:.....:::.::.:.|...:
Zfish  1217 ---------DASVPK-------TDKQSDSRERAPLSKQGP-TLKLHQHRSPRRRGQQPKLLNSPE 1264

  Fly   930 EALEAERAAKEAEEQRQREEIENKRLKAEMETRRKAAEAQRLRQEEE 976
            ::|......:..:.|..:.:            .||..:.:.|..|:|
Zfish  1265 DSLYYNHLNRSLDYQGSKRK------------PRKLGQIKLLDGEDE 1299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	290/1022 (28%)
		MYSc_Myo6	71..754	CDD:276833	242/755 (32%)
		CBD_MYO6-like	765..913	CDD:409646	31/168 (18%)
		ERM_helical	<954..1020	CDD:466641	5/23 (22%)
		MYO6_MIU_linker	1002..1093	CDD:480843
		MyUb_Myo6	1076..1116	CDD:439319
		Myosin-VI_CBD	1160..1246	CDD:465157
myo3b	XP_073768512.1	None