Protein Alignment jar and myh14

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_005157988.2
• Gene: myh14 / 563011
• ZFINID: ZDB-GENE-100921-1
• Length: 2060
• Species: Danio rerio
• Alignment Length: 1416
• Identity: 403/1416 - (28%)
• Similarity: 602/1416 - (42%)
• Gaps: 387/1416 - (27%)

  Fly     6 QLVWVRDAAEGYIQGRITEIGAKEFEVTPTD-------------RKYPKRTCHFDDIHSSCDGPQ 57
            :||||.....|:....|.|....|.||..||             |..|.|   |..:
Zfish    41 RLVWVPSEKHGFESASIREERGDEVEVELTDSGRKLTLLREELQRMNPPR---FSKV-------- 94

  Fly    58 DHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGE 122
              :|..:|..||||:.|.||:.|||...||||.....:.:|||:.: .:|....|:.|.|:...|
Zfish    95 --EDMADLTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKNL-PIYTESIIEMYRGKKRHE 156

  Fly   123 LPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY---SHDSA--------- 175
            :|||::||::.|.|.|...:..|||:.:|||||||||:||.:::||.:   ||.|.
Zfish   157 MPPHIYAISEAAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSGTLGRPKDTV 221

  Fly   176 ----------------------GPIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKC 218
                                  |.:|.::|.|||:|||||||||.:|:|||||||||.:::|...
Zfish   222 VQMDGTRSLGRGSSAVNRTVQYGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVAG 286

  Fly   219 QVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFAN 283
            .:||..|..|||||||...|:.:||.:|:||.||:||.:.:|.:|.||..|.||:|.|
Zfish   287 YIVGANIETYLLEKSRAIRQAKDERTFHIFYQLLSGATEAMRKELLLGGADQYRFLCG------- 344

  Fly   284 AKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGN 348
                               |.|..|...|.::|.....::..:|.:..|...:..::::||..||
Zfish   345 -------------------GSLPVPGQSDSENFTQTMDSMTIMGFTQEESTSMLKVISSVLQFGN 390

  Fly   349 IAFEE--------IPDDVRGGCQVSEASEQSLTITSGLLGVDQTEL-RTALVSRV---------M 395
            |.|.:        :|||         .:.|.|   ..|||:...|. |..|..|:         .
Zfish   391 ITFHKEKNTDQASMPDD---------TAAQKL---CHLLGISVLEFSRAILTPRIKVGREYVQKA 443

  Fly   396 QSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSI---PFQASNFYIGVLDI 457
            |:|               .:|..|.:|||||.|.|||..:|..||:::   ..|.::| ||:|||
Zfish   444 QTK---------------QQADFAVEALAKATYERLFRWLVHRINRALDRRQRQGASF-IGILDI 492

  Fly   458 AGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITF-TDNQDIIELIE-- 519
            ||||.|.:|||||.||||.|||||:.||..:...|||.|:|||:....|.| .|.|..|:|||
Zfish   493 AGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVLEQEEYQREGIEWNFIDFGLDLQPCIDLIERP 557

  Fly   520 AKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAG 584
            |...|:..|||||...|:.:...|..::.....:|.:...||.        |::|..|.:.|:||
Zfish   558 AHPPGVLALLDEECWFPRATDRSFVDKLSAEQGSHSKFMRPRQ--------LKEEADFSIIHYAG 614

  Fly   585 AVCYNTEQFIEKNNDALHASLEGLVQECDNPL--------LQTL-----FPSGSSTSVRG----- 631
            .|.|...:::.||.|.|:.::..|:.:..:|.        :|||     |.|.::....|
Zfish   615 KVDYKANEWLVKNMDPLNDNVASLLHQSSDPFISELWREDIQTLPRVYFFDSYATLQTNGCDSME 679

  Fly   632 ---------------------------KLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSK 669
                                       |..|.:||..:|..|.:||..|.....||:|||.||.:
Zfish   680 RIVGLDQVSSGENSGPVSFGAAGLKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFLRCIIPNHE 744

  Fly   670 MIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPARTF----- 729
            ....:....|.|.||:|:|.:..:.:...|:|:|:.|.:....|: :|.|..:   .|||
Zfish   745 KRAGKLSPHLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYE-ILTPNAI---PRTFMDGKH 805

  Fly   730 -CEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSAL 793
             .|.|..:|.|....|:.|.:|||||.|.....:.      |..|    |:...:||
Zfish   806 ASELMISALELDKNLFRVGQSKVFFRAGVLAHLEE------ERDL----KITDTIIR-------- 852

  Fly   794 GALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMG 858
                                 .|..|||:||||....:.|.:..:..::.|      .|:.||:.
Zfish   853 ---------------------FQSAARGYLARKAFHKKQQQLSALRVMQRN------CAAYLKLR 890

  Fly   859 REEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQE 923
            ..:...    ::.::...::..:.:..|..||  :........::||.:|.....|:.||..|::
Zfish   891 NWQWWR----LFTKVKPLLQVTRQDEEIQARE--AQLQKAKDKLSKLELDFTELDKKNQQLIEEK 949

  Fly   924 RLRKIQEALEAERAAKEAEEQRQR-----EEIEN------KRLKAEME-TRRKAAEAQRLRQEEE 976
            .:...|...|||..| ||||.|.|     :|:|:      .||:.|.| |.:...|.:|::|..:
Zfish   950 SVLTDQLQAEAELFA-EAEEMRARLANRKQELEDVLGELESRLEEEEERTVQLTNEKKRIQQHVQ 1013

  Fly   977 DRRAALALQEQLEKEAKDDAKYRQQLEQ------------------ERRDHELALRLANESNGQV 1023
            |      |:||||:|  :..:.|.|||:                  |:||     ||:.|.. |:
Zfish  1014 D------LEEQLEEE--EGTRQRLQLEKVTLESKVKSLEAETLTLAEQRD-----RLSKEKK-QL 1064

  Fly  1024 EDSPPVIRNGVNDASPMGPNKLISFSQ-------VVSNIASRYLNKSENVRAQQQALGKQKYDLS 1081
            |:.    .|.|.|.......|:.|.::       |:::|..| |.:.|..|.:|:
Zfish  1065 EER----LNEVTDQLTEEEEKVKSLNKLKNKQEAVIADIEER-LKREEQGRLEQE---------- 1114

  Fly  1082 KWK--------------------YSELRDAIN------TSCDIELLE--ACRQEFHRRLKVYHAW 1118
            |||                    .:|||.:::      |:....|.|  |.|.|..|.|:...:.
Zfish  1115 KWKRRMEGEAVEAQEQLSDMSLLVTELRGSLSQREKEITTLQTRLEEEGARRTEAQRALREAMSQ 1179

  Fly  1119 KAKNRKRTTMDENERAPRSVMEAAFKQPPLVQPIQEIVTAQHRYFRIPFMRANAPDNTKRGLWYA 1183
            .::.::..   ||||..|   |.|.||.   :.:.|.:.|         :|....|..
Zfish  1180 VSELKEEV---ENERGMR---ERAEKQR---RDLGEELEA---------LRTELEDTL------- 1219

  Fly  1184 HFDGQWIARQMELHADKPPILLVAGTDDMQMCELSLEETGLTRKRGAEILE 1234
                ...|.|.||.:.:.     |...::|.|   |||.  ||:..|::.|
Zfish  1220 ----DTTAAQQELRSRRE-----AELGELQRC---LEEE--TRRHEAQLSE 1256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	16/54 (30%)
		MYSc_Myo6	71..754	CDD:276833	258/791 (33%)
		CBD_MYO6-like	765..913	CDD:409646	24/147 (16%)
		ERM_helical	<954..1020	CDD:466641	25/84 (30%)
		MYO6_MIU_linker	1002..1093	CDD:480843	28/135 (21%)
		MyUb_Myo6	1076..1116	CDD:439319	14/67 (21%)
		Myosin-VI_CBD	1160..1246	CDD:465157	16/75 (21%)
myh14	XP_005157988.2	None