Protein Alignment jar and myo5c

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_691143.2
• Gene: myo5c / 562676
• ZFINID: ZDB-GENE-131127-196
• Length: 1746
• Species: Danio rerio
• Alignment Length: 1245
• Identity: 349/1245 - (28%)
• Similarity: 565/1245 - (45%)
• Gaps: 234/1245 - (18%)

  Fly     8 VWVRDAAEGYIQGRI-TEI--GAKEFEVTPTDRKYPKRTCHFDDIHSSCDGPQ------------ 57
            ||:.||...:....| |:.  |..|.|:...|.         .::|...:|.:
Zfish    13 VWIPDAEHVWKSAEILTDFKPGDSELELQLEDG---------TELHYPLEGGEKLPPLRNPDILV 68

  Fly    58 DHDDNCELMLLNEATFLDNLKTRYYKDK-IYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLG 121
            ..:|...|..|:|...|.|||.|:.:.| ||||...||:|||||::: .:|....|..|:|:::|
Zfish    69 GENDLTALSYLHEPAVLHNLKVRFVESKIIYTYCGIILVAVNPYKQL-PIYGDAVIHAYSGQNMG 132

  Fly   122 ELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGP--IETKILD 184
            :|.||:||:|::|.:.|.....:||||||||||||||.|.:|.::|......|...  :|.|:|.
Zfish   133 DLDPHIFAVAEEAYKQMARNNKNQSIIVSGESGAGKTVSARYAMRYFAMVSKSGSKTRVEDKVLA 197

  Fly   185 ANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFY 249
            :||:.||.||||||||:|||||||:.|:.:|.:.|::|..:..|||||||:..||..|||||:||
Zfish   198 SNPITEAIGNAKTTRNDNSSRFGKYTEISFDKRYQIIGANMRTYLLEKSRVVFQSENERNYHIFY 262

  Fly   250 MLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQ 314
            .:.|.|.|           .:::.|.              :.|::|....:..|.::...:||..
Zfish   263 QMCACANQ-----------PEFKGLR--------------LLGAEKFNYTRLGGEIEIEGVDDRA 302

  Fly   315 HFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFE-EIPDDVRGGCQVSEASEQSLTITSGL 378
            ......:....|||.:..:..::.::||:|||||:..: :.|:....|     :.:..|.|...|
Zfish   303 DMAETRRTFNLLGLKENFQTDVFKVLAAILHLGNVIIKAKDPEKSFIG-----SRDPHLAIFCDL 362

  Fly   379 LGVDQTELRTALVSR--VMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQ 441
            :||....:...|..|  |:.::       .::.|.....|.||||||||.||:.||:.::..||.
Zfish   363 MGVSTENMSRWLCHRRIVLSTE-------TVVKPQPRERAVNARDALAKHIYAHLFNWVIHKINH 420

  Fly   442 S--IPFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVP 504
            :  :|.:..:| ||||||.|||.|.:||||||||||.|||||:.||.::.|.|||.|.:|.:...
Zfish   421 ALMVPGKQHSF-IGVLDIYGFETFEINSFEQFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWT 484

  Fly   505 EITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHR 569
            .|.|.|||.:|:|||||. ||..|||||...|:.:..::..:::....:......||.|
Zfish   485 LIDFYDNQPVIDLIEAKM-GILDLLDEECLFPQGTDKNWLQKLYNFLGSKPLFEKPRLS------ 542

  Fly   570 TLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF------------- 621
                .:.|:::|||..|.|..:.|:|||.|.|:..|..:::.....||...|
Zfish   543 ----NDSFMIQHFADKVEYQCKGFLEKNRDTLYEELVDIMRASQFALLAGFFKEEEADSGHKIIK 603

  Fly   622 --PSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQL 684
              |:........|....:||.||::.|..|||.|.....:::||||||.:.:..:::....:.||
Zfish   604 VTPAQPRVKASNKQLRSTVGDKFRSSLYLLMETLNATTPHYVRCIKPNEEKLPFEYDSRRVVQQL 668

  Fly   685 KCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSL-PARTFCEAMFQSLNLSAKDFKFGI 748
            :..|.:..:.:....||||..:.:.||.|..::....:.| ..:..|..:.|.|...:..:|||.
Zfish   669 RACGVLETIRISAQSYPSRWTYVEFYSRYSILMSQSELKLGEKKQTCRTVLQRLIPDSNQYKFGR 733

  Fly   749 TKVFFRPGKFVEFDRIMRSDPENMLAIVAK-VKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCV 812
            ||:|||.|:....:::...........:.| |:.|..|..::.....|| :|:|..|...:.:|.
Zfish   734 TKIFFRAGQVAYLEKLRLDHLRAACVTIQKHVRGWRQRRSFLNIRQAAL-IIQLYVRGKKQIRCT 797

  Fly   813 LIAQRI-----------------------------------ARGFLARKQH-------------- 828
            :.||.:                                   .||::|||::
Zfish   798 VTAQALKQGWAAIVIQRHCRGFLVRRIYQLVLRAAVTIQAFTRGWMARKRYKKMVAEHKALVLQK 862

  Fly   829 -------RPRYQGIGKI--------------------NKIRTNTL-KTIEIASGLKMGREEI--- 862
                   |.|:|.:.::                    ||.....: |...:::....|.|:|
Zfish   863 YARAWLVRRRFQTMRRLVINVQLSYRVQQLRKKVEEQNKENCGLMEKLTSLSNARAQGLEKIQAL 927

  Fly   863 ISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVD---LNTKLKE---QQQAEE 921
            .:.:..:..::...:::.|.|.....:.:|    |:..:..||..:   |..|||:   |.|.:.
Zfish   928 EAELGKLTNEMSALVQRAKTNSEEANQAID----VLQNDKEKLVEENKALERKLKDTTVQMQDQF 988

  Fly   922 QERLRKIQEALEAE---RAAKEAEEQRQREEIENKRLKAEMETRRKAAEAQRLR-QEEEDRRAAL 982
            ::..||:.|.||.|   |...|...:.|:|:.:.:.:..:.|.||...|..||: |.|||.:...
Zfish   989 EDVKRKLMEDLEREERLRKVAEHNSELQKEDSDKEIVAIKEENRRLREERIRLQTQVEEDVKTNT 1053

  Fly   983 ALQEQ-------------LEKEAKDDAKYRQQLEQERR----------------------DHELA 1012
            .||||             |.||..:....|.:.|:..|                      :.:|.
Zfish  1054 ELQEQMLQLTKHVKVIPDLRKEINNLQIQRAEAEKTLRAQNLQARAKMNLITRQLLGDATEQDLI 1118

  Fly  1013 LRLANESNGQVEDSPPVIR--NGVNDASPMGPNKLISFSQVVSNIASRYLNKSENV---RAQQQA 1072
            .||..|::...:|...:|.  :|:..|:.:...:|........:.....:.|:|::   ..|.||
Zfish  1119 QRLNEEASDNNDDGADLITAFDGMERAAKVMETQLREQKDAHESQLEALIFKNEHLSKENEQLQA 1183

  Fly  1073 LGKQKYDLSK 1082
            |.::|.|:::
Zfish  1184 LFQEKSDINQ 1193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/43 (23%)
		MYSc_Myo6	71..754	CDD:276833	245/706 (35%)
		CBD_MYO6-like	765..913	CDD:409646	33/231 (14%)
		ERM_helical	<954..1020	CDD:466641	24/101 (24%)
		MYO6_MIU_linker	1002..1093	CDD:480843	19/108 (18%)
		MyUb_Myo6	1076..1116	CDD:439319	2/7 (29%)
		Myosin-VI_CBD	1160..1246	CDD:465157
myo5c	XP_691143.2	COG5022	12..1333	CDD:227355	349/1245 (28%)
		MYSc_Myo5	82..739	CDD:276831	245/706 (35%)
		Myo5c_CBD	1366..1740	CDD:271260