Protein Alignment jar and myo5aa

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_068071029.2
• Gene: myo5aa / 562188
• ZFINID: ZDB-GENE-041027-2
• Length: 1892
• Species: Danio rerio
• Alignment Length: 1403
• Identity: 390/1403 - (27%)
• Similarity: 630/1403 - (44%)
• Gaps: 318/1403 - (22%)

  Fly     2 LEDTQLVWVRDA--------AEGYIQGRITEIGAKEFEVTPTDRKYPKRTCHFDDIHSSCDGPQD 58
            :.|.:.|| |.|        .:|.:|.::.:....||::.|.....|    |.    .:.|....
Zfish    17 IPDDEEVW-RSAELTKDYRQGDGVLQLQLEDGKDLEFKLDPKTNNLP----HL----RNPDILVG 72

  Fly    59 HDDNCELMLLNEATFLDNLKTRYYKDK-IYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGE 122
            .:|...|..|:|...|.|||.|:...| ||||...:|:|:||| |...:|..|.|..|:|:::|:
Zfish    73 ENDLTALSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPY-ETLPIYGADIINAYSGQNMGD 136

  Fly   123 LPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGP--IETKILDA 185
            :.||:||:|::|.:.|...:.:||||||||||||||.|.||.::|......||..  :|.|:|.:
Zfish   137 MDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLAS 201

  Fly   186 NPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYM 250
            ||::|:.||||||||:|||||||:||:.:|.|..::|..:..|||||||:..|:.||||||:||.
Zfish   202 NPIMESIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADEERNYHIFYQ 266

  Fly   251 LLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQH 315
            |.|.|.......|.|||.:|:.|                        ..|.:.|:.|. :||.:.
Zfish   267 LCASAHLPEFKALKLGKANDFHY------------------------TKQGRNPVIDG-VDDAKE 306

  Fly   316 FHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLG 380
            ......|...||::::.::|::.::|::|||||:..::...|    ..:...:...|::...|:|
Zfish   307 MSTTRNAFILLGINESYQMGLFQILASILHLGNVDVKDRDSD----SSIIPPNNGHLSVFCELMG 367

  Fly   381 VDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPF 445
            |...::...|..:.:::....:     :.|:...:|.||||||||.||::||:.||..:|:::..
Zfish   368 VTYQDMSHWLCHKKLKTATETY-----IKPIPKLQAINARDALAKHIYAKLFNWIVDHVNKALHS 427

  Fly   446 QA-SNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFT 509
            .. .:.:||||||.|||.|.:||||||||||.|||||:.||.::.|.|||.|.:|.:....|.|.
Zfish   428 TVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFY 492

  Fly   510 DNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANH-YRLGLPRSSRLKAHRTLRD 573
            |||..|.|||||. ||..|||||.|:||.|        ..|||.. |...|...:..:..|  ..
Zfish   493 DNQPCINLIEAKM-GILDLLDEECKMPKGS--------DDSWAQKLYNTHLKTCALFEKPR--MS 546

  Fly   574 EEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF--------PSGSSTSVR 630
            .:.|:::|||..|.|..:.|:|||.|.::.....:::.....||..||        |:|::....
Zfish   547 NKAFIIQHFADKVEYQCDGFLEKNKDTVNEEQINVLKASKFDLLVELFHDEEKATSPTGAAPGPG 611

  Fly   631 GKLNFI-----------------SVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGS 678
            |:....                 :||.:|:..|..|||.|.....:::||||||.......|:..
Zfish   612 GRTRLSVKPDKGKSSQASKEHKKTVGLQFRNSLQLLMETLNATTPHYVRCIKPNDYKHAFTFDPK 676

  Fly   679 LALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPARTFCEAMFQSLNLSAKD 743
            .|:.||:..|.:..:.:...|:|||..:.:.:|.|:.::..:.|....:..|:.:.:.|......
Zfish   677 RAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLTDKKMTCKNVLEKLVQDPDK 741

  Fly   744 FKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKK----WLIRSRWVK-------------- 790
            ::||.||:|||.|:....:: :|:|  .:.|...:::|    ||.|.::::
Zfish   742 YQFGKTKIFFRAGQVAYLEK-LRAD--KLRAACIRIQKTIRCWLARKKYLRMKHAATTIQRFVRG 803

  Fly   791 -------------------------------------SALGALCVIK------LRNRIIYRNKCV 812
                                                 :||...|:::      |...::..:|.|
Zfish   804 YQARCLAKFLRRTRAAIIIQKYQRMYIQKTCYKRKQAAALAMQCILRAYMARQLYKALLREHKAV 868

  Fly   813 LIAQRIARGFLARKQHRPRYQGI-------------GKINKIRTNTLKTIEIASGLKMGREEIIS 864
            :| |::.||:|||:..:...:.|             .::.|::... :::|....|.:|.|   :
Zfish   869 II-QKMVRGWLARQWFKRSLKAIVYLQCCIRRMRAKRELKKLKIEA-RSVEHFKKLNIGME---N 928

  Fly   865 GVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLR-KI 928
            .:..:.|:|||..|:   |..:::|                   |||  .|...|.|.||:| ::
Zfish   929 KIMQLQRRIDDQNKE---NRSMSER-------------------LNT--LETSHAVESERMRAEV 969

  Fly   929 QEALEAERAAKE---------AEEQRQREEIENKRLKAEMETRRKAAE--AQRLRQEEEDRRAAL 982
            .....||..||.         .|.:|.|::::|      .:..:||.|  ||..:.|.|...:.|
Zfish   970 TRLRGAEEDAKNNANKVTSLLEELERLRKDLQN------TQKEKKAIEDWAQTYQDEMEKMISEL 1028

  Fly   983 ALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLIS 1047
            ..|.||.|..|::.....| ||.::..:...|...|...|:|       |.:|:.
Zfish  1029 KEQNQLLKTEKNNLNQLIQ-EQSQQWTDKMQRALKEETQQLE-------NDLNEE---------- 1075

  Fly  1048 FSQVVSNIASRYLN-KSENVRAQQQALGKQKYDLSKWKYSELRDAINTSCDIELLEACRQEFHRR 1111
                    .|||.| .:|::|.::             ||.:|::.|..:.::.      :..|||
Zfish  1076 --------RSRYQNLLTEHLRLEE-------------KYDDLKEEITLAVNVP------KPGHRR 1113

  Fly  1112 LKVYHAWKAKNRKRTTMD----ENERAPR-------SVMEAAF---KQPPLVQPIQEIVTAQHRY 1162
            ....|   :.|....|.:    |:|...|       |:::.:.   .|..:.:..||..:.|:..
Zfish  1114 TDSTH---SSNESECTYNSEFAESEEGSRVGEDVSKSILDMSLFLKLQKRVSELEQEKQSLQNEL 1175

  Fly  1163 FR--IPFMRANAPDNTKRGLWYAHFDGQWIARQMELHADKPPILLVAGTDDMQMCELSLEETGLT 1225
            .|  ..|.||.|.|:.:...          ||..||..:                .|..:|....
Zfish  1176 DRREEQFQRARARDDEEHKK----------ARGAELEYE----------------SLKRQELESE 1214

  Fly  1226 RKRGAEILEHEFN--REWERNGGKAYKNLGAAKPNGPA 1261
            .|:    |:|:.|  |:..|.|.:|    |:..|..||
Zfish  1215 NKK----LKHDLNQMRQSLRGGAEA----GSGAPGSPA 1244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	11/49 (22%)
		MYSc_Myo6	71..754	CDD:276833	250/712 (35%)
		CBD_MYO6-like	765..913	CDD:409646	36/221 (16%)
		ERM_helical	<954..1020	CDD:466641	18/67 (27%)
		MYO6_MIU_linker	1002..1093	CDD:480843	17/91 (19%)
		MyUb_Myo6	1076..1116	CDD:439319	7/39 (18%)
		Myosin-VI_CBD	1160..1246	CDD:465157	18/89 (20%)
myo5aa	XP_068071029.2	None