DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and myo1d

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	XP_688008.5	Gene:	myo1d / 559562	ZFINID:	ZDB-GENE-130531-15	Length:	1004	Species:	Danio rerio

Alignment Length:	949	Identity:	284/949 - (29%)
Similarity:	445/949 - (46%)	Gaps:	184/949 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DHDD----NCELMLLNEAT---FLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKY 115
            :|:.    ..:.:||:..:   |:.|||.|:.|.:||:|:..::::|||||.: .:|..|.|::|
Zfish     3 EHESLEFGKADFVLLDNVSLEEFMANLKLRFEKGRIYSYIGEVVVSVNPYRAM-NIYGRDVIEQY 66

  Fly   116 NGRSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIET 180
            .||.|.|.|||:|||||.|.:.|:.......|::||||||||||::||:::|:....:.:...|.
Zfish    67 KGRELYERPPHLFAIADAAYKAMKRRNKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEV 131

  Fly   181 K-----ILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSA 240
            :     :|.:|.||||||||||.||:|||||||::::::|.|...:||:|::|||||||:..|..
Zfish   132 ERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIFQQE 196

  Fly   241 EERNYHVFYMLLAGAPQ-QLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGP 304
            .||::|.||.|:.|||. |||.......|..|.|:.              :.|..||.
Zfish   197 GERSFHSFYQLVKGAPDAQLRSLHIQRDPTAYNYIK--------------VGGQLKSS------- 240

  Fly   305 LKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASE 369
                 |:|...|..:..|:..:|.:..|...:|.::|.:|||||:.|     ...|...:.|.|
Zfish   241 -----INDSAEFKAVADAMKVIGFTTEEIQTVYKILATILHLGNLKF-----GTDGDVTLIENS- 294

  Fly   370 QSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIY-EASNARDALAKAIYSRLFD 433
            :.:::...||...:..:..|::.|.:.:      |..::.....: |||..|||||||||.|||.
Zfish   295 KLVSVLGDLLSTKEENVEKAMLYRTVAT------GRDVIDKQHTHQEASYGRDALAKAIYERLFC 353

  Fly   434 RIVGLINQSIPFQ-------ASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKN 491
            .|||.||..|..:       ..|..||||||.|||.|..||||||||||||||||:.|...:||.
Zfish   354 WIVGRINDIIEVKNYDARVHGKNTVIGVLDIYGFEIFQNNSFEQFCINYCNEKLQQLFIQLVLKQ 418

  Fly   492 EQELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDE-----------------ESKLPKPS 539
            |||.|:|||:....|.:.:||.|::|:|.:..|||.:|||                 ..||.|
Zfish   419 EQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIFAVLDEACMNVGKVTDEMFLQALNGKLAK-- 481

  Fly   540 YSHFTAEVHKSWANHYRLGLPRSSRLK-AHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHA 603
            ::|:|                 |.:|. ..:.|..|..|.:||:||.|.|:...||:||.|.|..
Zfish   482 HAHYT-----------------SRKLSPTDKNLEFERDFRIRHYAGDVTYSVVGFIDKNKDTLFQ 529

  Fly   604 SLEGLVQECDNPLLQTLFPSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNS 668
            ..:.|:....||:|:.::|.|..:........::..:.||..:..|:|||......::||||||.
Zfish   530 DFKRLLYNSSNPVLKAMWPEGKLSITEVTKRPLTAATLFKNSMISLVEKLASKEPYYVRCIKPND 594

  Fly   669 KMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPARTFCEAM 733
            ......||......|::..|.:..:.:...|:.:|..:......||.:             .|..
Zfish   595 VKSPLLFEHERCKHQVEYLGLLENVRVRRAGFANRQTYPRFLQRYKMI-------------SEFT 646

  Fly   734 FQSLNLSA---------------KDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWL 783
            :.:.:||:               .|..:|.||||.|             .|..:.::..:
Zfish   647 WPNHDLSSDKEAVKRLLQGCGFEHDVAYGKTKVFIR-------------TPRTIFSLEEQ----- 693

  Fly   784 IRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKT 848
             |:..||                   :.||..|::.||.|||.::|.....:..|...|...:|:
Zfish   694 -RAEMVK-------------------RIVLFLQKVWRGTLARMRYRRMRAALIIIRAYRRYKVKS 738

  Fly   849 IEIASGLKMGREEIISGVNDIYRQIDDAIKKIK--MNPRITQREMDSM---------YTVVMANM 902
            .         ..|:|....:: |.:.|..|.:|  ..|::.::..:::         :|::....
Zfish   739 Y---------IREVIRRFKNV-RDMKDHGKHVKWPTPPKVLRKFEEALRSIYNRWWAWTLIKPLS 793

  Fly   903 NKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEA 941
            .:.||.:..|:...:..:.|.....:|.|.|.....|::
Zfish   794 PEKTVQIRAKVATLECLKGQRADLGLQRAWEGNYLKKDS 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	251/748 (34%)
		MYSc_Myo6	71..754	CDD:276833	248/732 (34%)
		RILP-like	<968..1015	CDD:304877
		Myosin-VI_CBD	1160..1246	CDD:293129
myo1d	XP_688008.5	MYSc_Myo1	23..682	CDD:276829	248/729 (34%)
myo1d	XP_688008.5	Myosin_TH1	803..994	CDD:336273	6/30 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010