Protein Alignment jar and MYO5C

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_061198.2
• Gene: MYO5C / 55930
• HGNCID: 7604
• Length: 1742
• Species: Homo sapiens
• Alignment Length: 1357
• Identity: 376/1357 - (27%)
• Similarity: 613/1357 - (45%)
• Gaps: 281/1357 - (20%)

  Fly     8 VWVRDAAEGYIQGRITE---IGAK------------EFEVTPTDRKYPKRTCHFDDIHSSCDGPQ 57
            ||:.|..|.:....|.:   :|.|            ::.|.| :...|.|.   .||...
Human    13 VWIPDPEEVWKSAEIAKDYRVGDKVLRLLLEDGTELDYSVNP-ESLPPLRN---PDILVG----- 68

  Fly    58 DHDDNCELMLLNEATFLDNLKTRYYKDK-IYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLG 121
             .:|...|..|:|...|.||:.|:.:.| ||||...||:|:|||::: .:|....|..|:|:::|
Human    69 -ENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQL-PIYGDAIIHAYSGQNMG 131

  Fly   122 ELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLC--YSHDSAGPIETKILD 184
            ::.||:||:|::|.:.|.....:||||||||||||||.|.:|.::|..  ....|...:|.|:|.
Human   132 DMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSGSNAHVEDKVLA 196

  Fly   185 ANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFY 249
            :||:.||.||||||||:|||||||:.|:.:|.:.|::|..:|.|||||||:..||..|||||:||
Human   197 SNPITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHIFY 261

  Fly   250 MLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQ 314
            .|.|.|.|.....|.||..:::.|    |:...|.    :|.|                 ::|..
Human   262 QLCASAQQSEFKHLKLGSAEEFNY----TRMGGNT----VIEG-----------------VNDRA 301

  Fly   315 HFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQS--LTITSG 377
            ......|....||..:..::.::.::||:|||||:....:      |.:.|..||..  |.:...
Human   302 EMVETQKTFTLLGFKEDFQMDVFKILAAILHLGNVQITAV------GNERSSVSEDDSHLKVFCE 360

  Fly   378 LLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQS 442
            |||::...:...|.:|.:.:     ....::.|:...:|.||||||||.||:.|||.||..|||:
Human   361 LLGLESGRVAQWLCNRKIVT-----SSETVVKPMTRPQAVNARDALAKKIYAHLFDFIVERINQA 420

  Fly   443 IPFQA-SNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEI 506
            :.|.. .:.:||||||.|||.|.|||||||||||.|||||:.||.::.|.|||.|.:|.:....|
Human   421 LQFSGKQHTFIGVLDIYGFETFDVNSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLI 485

  Fly   507 TFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRL-GLPRSSRLKAHRT 570
            .|.|||.:|:|||||. ||..|||||..||..:..::..:::.::.|...| ..||.|
Human   486 DFYDNQPVIDLIEAKM-GILELLDEECLLPHGTDENWLQKLYNNFVNRNPLFEKPRMS------- 542

  Fly   571 LRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF--------PSGSST 627
               ...|:::|||..|.|..|.|:|||.|.::..|..:::.....|....|        |.||..
Human   543 ---NTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPPSPFGSMI 604

  Fly   628 SVRGKLNFI---------SVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQ 683
            :|:.....|         :|||||::.|..|||.|.....:::||||||.:.:..:|:....:.|
Human   605 TVKSAKQVIKPNSKHFRTTVGSKFRSSLYLLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQ 669

  Fly   684 LKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSL-PARTFCEAMFQSLNLSAKDFKFG 747
            |:..|.:..:.:....||||..:.:.||.|..::..:.:|. ..:..|:.:...|...:..::||
Human   670 LRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQELSFSDKKEVCKVVLHRLIQDSNQYQFG 734

  Fly   748 ITKVFFRPGKFVEFDRIMRSDPENMLAIVAK-VKKWLIRSRWVKSALGALCV------------- 798
            .||:|||.|:....:::..........:|.| ::.||.|.::::....||.:
Human   735 KTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKHMRGWLQRKKFLRERRAALIIQQYFRGQQTVRKA 799

  Fly   799 ---IKLRN---RIIYRNKC---------------VLIAQRIARGFLARKQHRPRYQGIGKINKIR 842
               :.|:.   .||.:..|               .:..|..:||||||:::|
Human   800 ITAVALKEAWAAIIIQKHCRGYLVRSLYQLIRMATITMQAYSRGFLARRRYR------------- 851

  Fly   843 TNTLKTIEIASGL---KMGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNK 904
                |.:|....:   |..|..:.       |:...:|::..:|.::|.|            :.:
Human   852 ----KMLEEHKAVILQKYARAWLA-------RRRFQSIRRFVLNIQLTYR------------VQR 893

  Fly   905 LTVDLNTKLKEQQ------------QAEEQERLRKIQEALE---AERAAKEAEEQRQREEIENKR 954
            |...|..:.||..            :|.:.|:::|::..||   ..|...|.:.:|.|:.:|.|.
Human   894 LQKKLEDQNKENHGLVEKLTSLAALRAGDVEKIQKLEAELEKAATHRRNYEEKGKRYRDAVEEKL 958

  Fly   955 LK-----AEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQ----ERRDHE 1010
            .|     :|:||:::..:.:...:.||.:.....|.:||..:.:.:.:.|..||:    :.:|:|
Human   959 AKLQKHNSELETQKEQIQLKLQEKTEELKEKMDNLTKQLFDDVQKEERQRMLLEKSFELKTQDYE 1023

  Fly  1011 LALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGK 1075
            ..::...|....::|....:::            |:....|.          |:.::|:...|.|
Human  1024 KQIQSLKEEIKALKDEKMQLQH------------LVEGEHVT----------SDGLKAEVARLSK 1066

  Fly  1076 QKYDLSKWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENERAPRSVME 1140
            |...:|:::.           :||||:|.:.:..:     |....|...|..|.|   ..:.::|
Human  1067 QVKTISEFEK-----------EIELLQAQKIDVEK-----HVQSQKREMREKMSE---ITKQLLE 1112

  Fly  1141 AAFKQPPLVQPIQEIVTAQHRYFRIPFMRANAPD----NTKRGLWYA-------------HFDGQ 1188
            :        ..|:::.:           |.:..|    |....||:|             ||..|
Human  1113 S--------YDIEDVRS-----------RLSVEDLEHLNEDGELWFAYEGLKKATRVLESHFQSQ 1158

  Fly  1189 WIARQMELHA-DKPPILLVAGTDDMQMCELSLEETGLTRKRGAEILEHEFNREWERN 1244
            ....:.|:.| :...:.|....:.:|  :|..||..:.     |.:.||..|....|
Human  1159 KDCYEKEIEALNFKVVHLSQEINHLQ--KLFREENDIN-----ESIRHEVTRLTSEN 1208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	11/55 (20%)
		MYSc_Myo6	71..754	CDD:276833	256/707 (36%)
		CBD_MYO6-like	765..913	CDD:409646	30/185 (16%)
		ERM_helical	<954..1020	CDD:466641	15/74 (20%)
		MYO6_MIU_linker	1002..1093	CDD:480843	14/94 (15%)
		MyUb_Myo6	1076..1116	CDD:439319	7/39 (18%)
		Myosin-VI_CBD	1160..1246	CDD:465157	21/103 (20%)
MYO5C	NP_061198.2	MYSc_Myo5	81..741	CDD:276831	256/707 (36%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	632..654		10/21 (48%)
		IQ	810..828	CDD:197470	3/17 (18%)
		IQ	831..851	CDD:459869	7/19 (37%)
		SMC_prok_B	<886..>1356	CDD:274008	74/402 (18%)
		Myo5c_CBD	1369..1736	CDD:271260