Protein Alignment jar and LOC556989

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_685035.4
• Gene: LOC556989 / 556989
• -ID: -
• Length: 1124
• Species: Danio rerio
• Alignment Length: 1239
• Identity: 346/1239 - (27%)
• Similarity: 530/1239 - (42%)
• Gaps: 364/1239 - (29%)

  Fly    60 DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELP 124
            :|...|..|:|...|:.|..|:.::.||||:.:||:|:||::.: .:|..:..::|.......||
Zfish    42 EDLANLSELDEKCLLEVLTGRFTQNLIYTYIGDILVAINPFKYL-SIYEKEVSQRYKCHEKKSLP 105

  Fly   125 PHVFAIADKAIRDM----RVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETKILDA 185
            ||:||:||:|.:.|    .:...:|.|::|||||||||||||.||:::.....:...:|.:||..
Zfish   106 PHIFAVADRAYQSMLGRLAMGPKNQCIVISGESGAGKTESTKLLLRHIMELCKANSQLEQQILQV 170

  Fly   186 NPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYM 250
            ||:|||||||:|..|:|||||||:|::.:. ...|.|..|:.|||||||:..|...|:|:|:||:
Zfish   171 NPLLEAFGNAQTVMNDNSSRFGKYIQLRFQ-NSSVKGAKINEYLLEKSRVVHQDQGEQNFHIFYL 234

  Fly   251 LLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQ- 314
            :|||...:.::...|..|..||||:|                        :.|  ::.::..::
Zfish   235 MLAGISLEDKEIYGLLDPTLYRYLNG------------------------RFG--QEDVVQTWRV 273

  Fly   315 HFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLL 379
            .:..:..|:..:|..:.||:.:.:::|.:|.||||.||....|   ..:|||||...|..|:|..
Zfish   274 KYAEVCNAMDMVGFEEQEKVDMMTILAGILSLGNITFETTDSD---ALKVSEASRGWLKATAGQF 335

  Fly   380 GVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIY---EASNARDALAKAIYSRLFDRIVGLINQ 441
            ||.:.:|..:|......::|...:        :::   :|.:|||::||..|.|:|..||..||:
Zfish   336 GVQEEDLLKSLTCTTSMTRGEAIQ--------RLHNQQQAEDARDSIAKVAYGRVFGWIVSKINE 392

  Fly   442 ----SIPFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLN 502
                .:.|......||:|||.|||.|.||.|||.|||..||:||.|||.:|...||:.||.||:.
Zfish   393 QLAPKVDFDVELNEIGILDIFGFENFAVNRFEQLCINLANEQLQYFFNHHIFLMEQKEYKEEGIT 457

  Fly   503 VPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKA 567
            ...||:.||:.|::|...|..||.:||||:|..|:.:...|..:::..:.:     .|....::.
Zfish   458 WETITYKDNKPILDLFLMKPIGILSLLDEQSAFPQATDRDFVDKLNSKFKS-----APNFEVVRN 517

  Fly   568 HRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFP-----SGSST 627
            |..|     |.|.|:||.|.||...|:|||.|.:.||:..|......|||..||.     :|:..
Zfish   518 HTPL-----FTVVHYAGKVQYNASGFLEKNRDTIPASIRELFINSVTPLLSVLFAATISRTGTLM 577

  Fly   628 SVRGKL-----NF-----ISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALA 682
            ..:.||     ||     .|||::||..|..||||:.....:|:||||||......|.:..|.|.
Zfish   578 PRKAKLQVSDDNFNSTRKQSVGAQFKHSLAVLMEKMFAASPHFVRCIKPNRSKQPDQLDSKLVLD 642

  Fly   683 QLKCSGTISVLELMEHGYPSRVLFADLYSMYK-SVLPPELVSLPARTFCEAMFQSLNLSAKDFKF 746
            ||:.:|.:..:.:...|:..|..|.:....|. .:|.|:|.:  .::.|.::..|..||.  :|.
Zfish   643 QLRYNGLMETIRIRRDGFSWRPTFREFAERYNILLLKPDLPT--DKSSCMSILNSTELSG--WKC 703

  Fly   747 GITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKC 811
            |.:::||:                                         ||
Zfish   704 GSSRLFFK-----------------------------------------LC-------------- 713

  Fly   812 VLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGL-KMGREEIISGVNDIYRQIDD 875
                            |:                   :|:|:.| ::||..::
Zfish   714 ----------------HQ-------------------VELANLLDRLGRAALV------------ 731

  Fly   876 AIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKE 940
             |:| ....|..:|:    |..::|           :|:.|:||
Zfish   732 -IQK-NFRARTCRRK----YLCLLA-----------ELRRQRQA--------------------- 758

  Fly   941 AEEQRQREEIENKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQE 1005
               ||:|||.|               |.:|.|||||.||     |:|.|.|    .|.|.::|||
Zfish   759 ---QREREERE---------------EEERRRQEEEKRR-----QQQQEAE----RKRRLEVEQE 796

  Fly  1006 RRDHELALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQ 1070
            .      ||.|         ||||         |: |.|.....:..|.::|  ::|:.:|....
Zfish   797 N------LRPA---------SPPV---------PL-PRKKKPEPRPRSVLSS--ISKTASVAPVP 834

  Fly  1071 QALGKQKYDLSKWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENERAP 1135
            :...|                        ||||...:                  ..::||....
Zfish   835 RPRSK------------------------LLEATPFD------------------NDLNENFHLD 857

  Fly  1136 RSVMEAAFKQPPLVQPI-QEIVTAQH-------RYFRIPFMRANAPDNTKRGLWYAH-FDGQWIA 1191
            .|:|         :||| :|.:..:|       |:||...:|....|.:     :.| |.|....
Zfish   858 ASLM---------LQPIDEERIKEKHLKKSNTIRWFRETQVRKLTRDGS-----FPHWFHGMITR 908

  Fly  1192 RQME-LHADKPPILLVAGTDDMQMCELSLEETGLTRK------RGAEILEHEFNREWERNGGKAY 1249
            ||.| |..|||             ....|...|.:|:      |||:...| :..|.:.||  .|
Zfish   909 RQAEDLLIDKP-------------LGCFLVRVGQSREGFTLTFRGADRCRH-YMVEMQSNG--KY 957

  Fly  1250 KNLG 1253
            ..||
Zfish   958 VILG 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	243/710 (34%)
		CBD_MYO6-like	765..913	CDD:409646	14/148 (9%)
		ERM_helical	<954..1020	CDD:466641	21/65 (32%)
		MYO6_MIU_linker	1002..1093	CDD:480843	18/90 (20%)
		MyUb_Myo6	1076..1116	CDD:439319	4/39 (10%)
		Myosin-VI_CBD	1160..1246	CDD:465157	25/100 (25%)
LOC556989	XP_685035.4	MYSc_Myo28	53..711	CDD:276854	243/710 (34%)
		SH2	895..992	CDD:472789	24/88 (27%)