DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and myo1b

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	XP_005168005.1	Gene:	myo1b / 541515	ZFINID:	ZDB-GENE-030131-695	Length:	1167	Species:	Danio rerio

Alignment Length:	1129	Identity:	333/1129 - (29%)
Similarity:	517/1129 - (45%)	Gaps:	212/1129 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIAD 132
            |:|.:|::|||.|:..::||||:.:::|::|||:.: .:|:.:.:::|..|:..||.||::|:||
Zfish    23 LSEESFIENLKKRFDHNEIYTYIGSVVISMNPYKSL-SIYSAEKVEEYRNRNFYELSPHIYALAD 86

  Fly   133 KAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKY---LCYSHDSAGPIETKILDANPVLEAFGN 194
            :|.|.:|.....|.|:::|||||||||::|:::.|   :|........::.::|.:|||||||||
Zfish    87 EAYRSLRHQDKDQCILITGESGAGKTEASKFVMSYVAAVCGKGQEVNKVKEQLLQSNPVLEAFGN 151

  Fly   195 AKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQL 259
            |||.||:|||||||::::.:|.|...:||.||:|||||||:..|...|||:|:||.||:||...:
Zfish   152 AKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHIFYQLLSGASDDM 216

  Fly   260 RDKLSLGKP-DDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKAL 323
            ..||.|.:. ..|.|||      .::.|   :.|                 :||...|..:..|:
Zfish   217 LKKLKLDRDFSKYNYLS------LDSAT---VNG-----------------LDDAASFRTVRNAM 255

  Fly   324 GRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQS-LTITSGLLGVDQTELR 387
            ..:|..:.|...|..|:||||.||||.|:  |:....|...|...::: |.....|||::|:.|.
Zfish   256 QIVGFMEDEVQSILELIAAVLKLGNIEFK--PESRVNGFDESRVKDKNDLKEMCELLGIEQSVLE 318

  Fly   388 TALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPFQAS--NF 450
            .|...|.:::     |...:...|.:.:|..|||||||.:|||||..:|..||:||..|..  ..
Zfish   319 RAFSFRTVEA-----KMEKVSTTLNVAQAYYARDALAKNLYSRLFTWLVNRINESIKAQTKTRKK 378

  Fly   451 YIGVLDIAGFEYFT--VNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQD 513
            .:|||||.|||.|.  .||||||.|||||||||:.|.:..|:.|||.|.|||:....|.:.:|..
Zfish   379 VMGVLDIYGFEIFENGDNSFEQFIINYCNEKLQQIFIELTLREEQEEYIREGIEWTNIEYFNNAI 443

  Fly   514 IIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWAN-------HYRLGLPRSSRLKAHRTL 571
            |.:|||...|||..:||||...|    ...|.|......|       |:...|.::|:.....:|
Zfish   444 ICDLIENNKNGILAMLDEECLRP----GTVTDETFLDKLNTVCAEHQHFESRLSKNSKFLTDHSL 504

  Fly   572 RDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVRGKLNFI 636
             ....|.::|:||.|.|..|.|::||||.|:..|...:.:.::.|::.|||.|:...|..| ...
Zfish   505 -PHNCFRIQHYAGKVLYRVEGFVDKNNDLLYRDLSQAMYKANHNLIKLLFPEGNPAKVNLK-RPP 567

  Fly   637 SVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYP 701
            :.|.:|:..:|.||:.|.....|:|||||||.|.....|..||...|::..|.:..:.:...||.
Zfish   568 TAGFQFRASVGTLMKNLLTKNPNYIRCIKPNDKKAAHIFTDSLVCHQVRYLGLMENVRVRRAGYA 632

  Fly   702 SRVLFADLYSMYKSVLP---PELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGK---FVE 760
            .|..:......||.:..   |.... |||...|.:...|.:.|::|.:|.:|:|.|..:   |:|
Zfish   633 FRQAYEPCLERYKMLCKQTWPHWKG-PAREGVEVLLSDLQVPAEEFAYGRSKIFIRNPRTLFFLE 696

  Fly   761 FDRIMRSDPENMLAIVAKV-KKWLIRSRWVKSALGALCVIKLRNRIIYRNK-----C-VLIAQRI 818
            ..|  |...|::.|::.|: :.|..|:.::......:.|.....|...:.|     | .|:.|..
Zfish   697 EKR--RQCLEDLAALIQKIYRGWKCRTHFLLLKKSQVVVAAWYRRFAQQKKYQKIRCSALVVQSF 759

  Fly   819 ARGFLARK-----QHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYR--QIDDA 876
            .||:.|||     :|:.|.                           ||.::.::..:.  |....
Zfish   760 IRGWKARKLLRELKHKKRC---------------------------EEAVTTISAYWHGTQARWE 797

  Fly   877 IKKIKMNPRITQREMDSMYTVVMANMNKLTVD------LNTKLKEQQQAEEQERLRKIQEALEAE 935
            ::::|...                 .||..|.      |.||.:.:.|..:.|...|  :|:...
Zfish   798 LRRLKKEA-----------------WNKHAVSVIWAAWLGTKARRELQKLKHEACSK--QAVSVI 843

  Fly   936 RAAKEAEEQRQREEIENKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQ 1000
            .|..:..:.|:    |.||||                 ||..|:.|:|:........|...:||:
Zfish   844 WACWQGTKARR----ELKRLK-----------------EEARRKHAIAVIWAYWLGLKVRREYRK 887

  Fly  1001 QLEQERRDHELALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSEN 1065
            ...            ||..                       .|:..|:  :..|..:|....:.
Zfish   888 FFR------------ANAG-----------------------KKIYDFT--IQRIIQKYYLGLKK 915

  Fly  1066 VRAQQQALGKQKYDLSKWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDE 1130
            .......:.|      .|          ::|....|:...||..|   ::|.|:.| :.|:...|
Zfish   916 TMPSMSPIDK------SW----------STCPYGFLDGTHQELRR---IFHLWRCK-KYRSQFTE 960

  Fly  1131 NERAPRSVMEAA---FKQPPLVQP 1151
            .::|......||   ||....:.|
Zfish   961 EKKATYEEKLAASELFKDKKALYP 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	257/704 (37%)
		MYSc_Myo6	71..754	CDD:276833	255/701 (36%)
		RILP-like	<968..1015	CDD:304877	8/46 (17%)
		Myosin-VI_CBD	1160..1246	CDD:293129
myo1b	XP_005168005.1	MYSc	13..700	CDD:214580	261/719 (36%)
		MYSc_Myo1	26..687	CDD:276829	255/701 (36%)
		Myosin_TH1	969..1142	CDD:283635	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920