Protein Alignment jar and Myo28B1

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Alignment Length: 1099
• Identity: 351/1099 - (31%)
• Similarity: 509/1099 - (46%)
• Gaps: 207/1099 - (18%)

  Fly    57 QDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLG 121
            :|.:|...|..|.|.|.|.||:.||.|..||||..::|:|:||| :|..:|....|:.|..:||.
  Fly    67 EDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPY-QILPIYTNREIQLYRNKSLA 130

  Fly   122 ELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETKILDAN 186
            |||||:|||:|.|.:.::..|.:|.:::|||||||||||||.:|:||.........||.:|::||
  Fly   131 ELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEAN 195

  Fly   187 PVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYML 251
            |::||||||||.||:|||||||:||:.:..:..:.|..|..||||||||..||.:|||||:||.:
  Fly   196 PIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCM 260

  Fly   252 LAGAPQQLRDKLSLGK--PDDYRYLS--GCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDD 312
            |||.....|::|.|.:  |..|.||:  ||.          .:||         :|..||
  Fly   261 LAGLSTAERERLKLQEQSPSQYHYLAQGGCF----------TLPG---------RGDAKD----- 301

  Fly   313 YQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAF----------EEIPDDVRGGCQVSEA 367
               |.::..|:..|.....|...|.||:||:|||||:.|          .||.|
  Fly   302 ---FADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDD----------- 352

  Fly   368 SEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLF 432
             ..:|...:.|||:..:.|..||..|.:     ...|..:...|....|...|||..|::|..:|
  Fly   353 -TPNLQRVAQLLGIPISALNAALTQRTI-----FVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIF 411

  Fly   433 DRIVGLINQSIPFQASN--FYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQEL 495
            .|||..||::|..|...  ..||||||.|||.|..|||||.||||.||.||:||..:|.|.||:.
  Fly   412 VRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDE 476

  Fly   496 YKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLP 560
            |:.|.:|...|.|.|||.|::||..|...:.:|:|||||.||.:......::|....|
  Fly   477 YQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGN------- 534

  Fly   561 RSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGS 625
            ||..:|...|  ....|.:||:||.|.||...|:|||.|:....|..|||...|..|..:||...
  Fly   535 RSIYVKGKTT--QTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPHEM 597

  Fly   626 STSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTI 690
            ......|...:.|  ||:..|..||..|.|....||||||||.....:.|:..|.:.||:.||.:
  Fly   598 PMDTAKKQPTLCV--KFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMM 660

  Fly   691 SVLELMEHGYPSRVLFADLYSMYKSVLPP-------ELVSLPARTFCEAMFQSLNLSAKDFKFGI 748
            ....:...|||.|..:......|:.::||       :...| ||..||....    :..|.::|.
  Fly   661 ETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKL-ARQICEVALP----ADSDRQYGK 720

  Fly   749 TKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIR---SRWVKSALGALCVIKLRNRIIYRNK 810
            ||:|.|.......: :.||  :.||..:..:::.:.|   .|::|.               || :
  Fly   721 TKLFLRDEDDASLE-LQRS--QLMLKSIVTIQRGIRRVLFRRYMKR---------------YR-E 766

  Fly   811 CVLIAQRIARGFLARKQHRPRYQG---IG----------KINKIRTNTLKTIEIASGLKMGREEI 862
            .::..||..||.|.|::::...||   :|          |...:|..|:|...::.|
  Fly   767 AIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRG-------- 823

  Fly   863 ISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRK 927
                   |....|..||:     :.:|:           .|:|..:...||.:.::|||..||::
  Fly   824 -------YLVRKDFQKKL-----LERRK-----------QNQLKKEELLKLAKMKEAEELLRLQQ 865

  Fly   928 IQEALEAERAAKEAEEQRQREEIENKRLKAEMETRR---KAAEAQRLR----QEEEDRRAALALQ 985
            ::|  :.||..:|.:|:|.:||   :|||||...|.   .||..|:.|    ::|..:...|..:
  Fly   866 LKE--QKEREQREQQEKRLQEE---QRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQAR 925

  Fly   986 EQL----------------------------EKEAKDDAKYRQQLEQE-----RRDHELALR-LA 1016
            ..|                            |.....|.:..:|:..:     ..:.:.||| |.
  Fly   926 NSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRKLN 990

  Fly  1017 NESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGK 1075
            |.|:|.....|..:.|.::.:         .||.:  ..|:.|.......:.:::.|.|
  Fly   991 NISSGDTIRLPKSVPNNIDTS---------DFSYL--KYAATYFGGGATAQHERKPLKK 1038

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	269/705 (38%)
		CBD_MYO6-like	765..913	CDD:409646	30/163 (18%)
		ERM_helical	<954..1020	CDD:466641	21/106 (20%)
		MYO6_MIU_linker	1002..1093	CDD:480843	15/80 (19%)
		MyUb_Myo6	1076..1116	CDD:439319	351/1099 (32%)
		Myosin-VI_CBD	1160..1246	CDD:465157
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	269/705 (38%)
		IQ	765..785	CDD:197470	7/20 (35%)
		Atrophin-1	<820..>946	CDD:460830	36/161 (22%)
		MyTH4	1031..1239	CDD:470587	2/8 (25%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612
		B41	1248..1429	CDD:214604
		PH-like	1454..1547	CDD:473070
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020