DRSC/TRiP Functional Genomics Resources

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Protein Alignment jar and MYO15A

DIOPT Version :10

Sequence 1:NP_001014650.2 Gene:jar / 42889 FlyBaseID:FBgn0011225 Length:1268 Species:Drosophila melanogaster
Sequence 2:XP_016880204.1 Gene:MYO15A / 51168 HGNCID:7594 Length:3531 Species:Homo sapiens


Alignment Length:853 Identity:284/853 - (33%)
Similarity:437/853 - (51%) Gaps:126/853 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 GPQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRS 119
            |....:|..:|..|.|.|.|.|||.|:.::.||||:.:||::|||| ::..:|.|:.:::||||:
Human  1220 GEDGVEDMTQLEDLQETTVLSNLKIRFERNLIYTYIGSILVSVNPY-QMFGIYGPEQVQQYNGRA 1283

  Fly   120 LGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIE--TKI 182
            |||.|||:||:|:.|...|...|.:|.||:|||||:||||:||.:|:||...:.....::  .:|
Human  1284 LGENPPHLFAVANLAFAKMLDAKQNQCIIISGESGSGKTEATKLILRYLAAMNQKREVMQQVIQI 1348

  Fly   183 LDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYI-SHYLLEKSRICTQSAEERNYH 246
            |:|.|:||:||||||.||:||||||||:|:..:.  .|:.|.| |.||||||||..|:..|||||
Human  1349 LEATPLLESFGNAKTVRNDNSSRFGKFVEIFLEG--GVISGAITSQYLLEKSRIVFQAKNERNYH 1411

  Fly   247 VFYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIID 311
            :||.||||.|.|||...||.:.:.|.||:                         |.|..:.....
Human  1412 IFYELLAGLPAQLRQAFSLQEAETYYYLN-------------------------QGGNCEIAGKS 1451

  Fly   312 DYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITS 376
            |...|..|..|:..||.|..::..|:.::|::|||||:.||:...|.:....|..|.|  :...:
Human  1452 DADDFRRLLAAMEVLGFSSEDQDSIFRILASILHLGNVYFEKYETDAQEVASVVSARE--IQAVA 1514

  Fly   377 GLLGVDQTELRTAL---VSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGL 438
            .||.:....|:.|:   |:..|:.|        |..||.:..|.:||||:||.:|:.||..::..
Human  1515 ELLQISPEGLQKAITFKVTETMREK--------IFTPLTVESAVDARDAIAKVLYALLFSWLITR 1571

  Fly   439 INQSIPFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNV 503
            :|..:..:.....|.:|||.|||..:.|||||.||||.||.||..||..:.:.|||.|.||.::.
Human  1572 VNALVSPRQDTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQIDW 1636

  Fly   504 PEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHY---------RLGL 559
            .||||.|||..|.||..|..||..:||::...|:.:...|..:.|    .|:         ::.|
Human  1637 QEITFADNQPCINLISLKPYGILRILDDQCCFPQATDHTFLQKCH----YHHGANPLYSKPKMPL 1697

  Fly   560 PRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPS- 623
            |.               |.::|:||.|.|...:|::||:|.:...:..|.......::..||.| 
Human  1698 PE---------------FTIKHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVRSRTRVVAHLFSSH 1747

  Fly   624 ---------GSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSL 679
                     |.|:||.......:|.:||:..|.:|:||:|:....|:||:|||.|.....||..:
Human  1748 APQAAPQRLGKSSSVTRLYKAHTVAAKFQQSLLDLVEKMERCNPLFMRCLKPNHKKEPGLFEPDV 1812

  Fly   680 ALAQLKCSGTISVLELMEHGYPSRVLFADLYSMY------KSVLPPE---LVSLPARTFCEAMFQ 735
            .:|||:.||.:..:.:.:.|:|.|:.|......|      |..||..   .||:.:| .|:.|  
Human  1813 VMAQLRYSGVLETVRIRKEGFPVRLPFQGFIDRYCCLVALKHDLPANGDMCVSVLSR-LCKVM-- 1874

  Fly   736 SLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIK 800
                 ...::.|::|:|.:...:    :::.|..|::|.:.|...:..:|..::|....:|    
Human  1875 -----PNMYRVGVSKLFLKEHLY----QLLESMREHVLNLAALTLQRCLRGFFIKRRFRSL---- 1926

  Fly   801 LRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKI------RTNTLK-----TIEIASG 854
                   |:|.:|:..| |||:|||::::...:.:.|...:      |...||     ..::...
Human  1927 -------RHKIILLQSR-ARGYLARQRYQQMRRSLVKFRSLVHAYVSRRRYLKLRAEWRCQVEGA 1983

  Fly   855 LKMGREEI 862
            |...:||:
Human  1984 LLWEQEEL 1991

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
jarNP_001014650.2 Myosin_N 7..49 CDD:460670
MYSc_Myo6 71..754 CDD:276833 255/716 (36%)
CBD_MYO6-like 765..913 CDD:409646 24/109 (22%)
ERM_helical <954..1020 CDD:466641
MYO6_MIU_linker 1002..1093 CDD:480843
MyUb_Myo6 1076..1116 CDD:439319
Myosin-VI_CBD 1160..1246 CDD:465157
MYO15AXP_016880204.1 SGP <320..364 CDD:435798
PHA03247 <723..1144 CDD:223021
MYSc_Myo15 1236..1888 CDD:276838 255/716 (36%)
IQ 1926..1947 CDD:197470 11/32 (34%)
MyTH4 2066..2218 CDD:214535
PHA03247 <2433..2673 CDD:223021
SH3_MYO15A 2872..2951 CDD:213000
MyTH4 3051..3205 CDD:214535
FERM_M 3300..3420 CDD:459788
FERM_C_MyoXV 3416..3517 CDD:270022
Blue background indicates that the domain is not in the aligned region.

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