DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and myo1a

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001008063.1	Gene:	myo1a / 493425	XenbaseID:	XB-GENE-979281	Length:	1073	Species:	Xenopus tropicalis

Alignment Length:	841	Identity:	291/841 - (34%)
Similarity:	436/841 - (51%)	Gaps:	98/841 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DIHSS-CDGPQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDT 111
            |..|| .||.....|...|..|:|.:.|.|||.|:..|:||||:.|::|:||||:.: .:|:|:.
Frog     2 DFKSSFMDGMVGVGDMILLESLSEESLLVNLKERFKSDEIYTYIGNVVISVNPYKSL-PIYSPEK 65

  Fly   112 IKKYNGRSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKY---LCYSHD 173
            :::|...:|.:|.||::|:||.|.:.:|.....|.|:::|||||||||::|.::.|   :|....
Frog    66 VEEYRNCNLYQLKPHIYAVADDAYQSLRDRDRDQCILITGESGAGKTEASKLVMSYVAAVCGKGT 130

  Fly   174 SAGPIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQ 238
            ....::.::|.:||||||||||||.||:|||||||::::.:|.|...:||.||:|||||||:...
Frog   131 EVNQVKEQLLQSNPVLEAFGNAKTIRNDNSSRFGKYMDIEFDFKGDPMGGVISNYLLEKSRVVKN 195

  Fly   239 SAEERNYHVFYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKG 303
            ...|||:|:||.||||...:|..||.| .||       |::|                 |:....
Frog   196 VKGERNFHIFYQLLAGGGTELLGKLKL-VPD-------CSKY-----------------NYLNND 235

  Fly   304 PLKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEAS 368
            |.....:.|.::|..:..|:..:||||.|...|..:||.:|.|||:       :::|..|.:..:
Frog   236 PSSLNGMGDNENFQIVKNAMEIIGLSDAEVTSILEIVAVILKLGNV-------EIKGQFQANGMA 293

  Fly   369 EQSLTITSG------LLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAI 427
            ...:|.|.|      |:|:|.:.|..|...|.:::     |...::..|...:...|||||||.:
Frog   294 ACYITDTKGIKEIGALIGLDSSMLENAFSVRTVEA-----KQEKVVTTLNQSQGIYARDALAKNL 353

  Fly   428 YSRLFDRIVGLINQSIPFQASNF----YIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNI 488
            |.|||..:|..||:||  :.|.|    .:|||||.|||...|||||||.|||||||||:.|....
Frog   354 YDRLFSWLVQRINESI--KVSEFQGRKVMGVLDIYGFEILEVNSFEQFIINYCNEKLQQIFIQMT 416

  Fly   489 LKNEQELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLP-KPSYSHFTAEVHKSWA 552
            ||.|||.|.|||:....|.:|||:.|..|||..:|||..:||||...| |.|.:.|.|::...:.
Frog   417 LKEEQEEYTREGIKWTRIVYTDNEVICTLIEDNTNGILAVLDEECLRPGKVSDATFLAKLGTKFK 481

  Fly   553 N--HYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNP 615
            |  |::..:.::.:..|..||.| ..|.:.|:||.|.|||:.|::||||.|...|...:....:.
Frog   482 NHKHFQSKVTQNDKRIADLTLPD-NCFRIEHYAGQVTYNTDGFLDKNNDLLFRDLSQAMWNAKHQ 545

  Fly   616 LLQTLFPSG--SSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGS 678
            ||:||||.|  .::|::..   .:||.:|:..:..||:.|.....|:|||:||||......|:..
Frog   546 LLKTLFPEGDPKNSSLKRP---PTVGFQFRNSVSTLMKNLYAKNPNYIRCLKPNSSKKPSLFDDV 607

  Fly   679 LALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLP---PELVSLPARTFCEAMFQSLNLS 740
            |...|:...|.:..:::...|:..|.|:......||.:..   |:... .||....||...|.:.
Frog   608 LVKTQILYLGLLENVKVRRAGFAYRQLYKPFLERYKMISKKTWPQWAG-EARDGVAAMMAELGIP 671

  Fly   741 AKDFKFGITKVFFR-PGKFVEF-DRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRN 803
            .::...|.||:|.| |....:. ||..|...|....|....:.|..|:.:         ::..::
Frog   672 DEEAALGHTKIFIRTPSTLFDLEDRRRRRLDELATLIQTLFRGWRCRTHF---------LLMRKS 727

  Fly   804 RII----YRNKC-----------VLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTI 849
            :|:    ||...           .|:.|...||:.||...|.     .|::|.:.:...||
Frog   728 QIVISAFYRGHAQKKEYQKIKFSALLLQAYVRGWKARVLLRK-----FKLDKRKESASSTI 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	263/715 (37%)
		MYSc_Myo6	71..754	CDD:276833	259/703 (37%)
		RILP-like	<968..1015	CDD:304877
		Myosin-VI_CBD	1160..1246	CDD:293129
myo1a	NP_001008063.1	MYSc_Myo1	31..685	CDD:276829	258/698 (37%)
myo1a	NP_001008063.1	Myosin_TH1	880..1073	CDD:399188
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010