Protein Alignment jar and MYO9B

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_004136.2
• Gene: MYO9B / 4650
• HGNCID: 7609
• Length: 2157
• Species: Homo sapiens
• Alignment Length: 1546
• Identity: 387/1546 - (25%)
• Similarity: 619/1546 - (40%)
• Gaps: 426/1546 - (27%)

  Fly    12 DAAEGYIQGRITEIGAKEFEVTPTDRK------YPKRTCHFDDIHSSCDG--------------- 55
            |..:.|:...:.|.|.:|:.:...|..      :|:|.   .|.|...||
Human    58 DGTKCYVLVEVKESGGEEWVLDANDSPVHRVLLWPRRA---QDEHPQEDGYYFLLQERNADGTIK 119

  Fly    56 ----------------------PQ---DHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILI 95
                                  |:   |.||.|.|..|.|...|.|||.|:.:.|||||..:||:
Human   120 YVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEGNLLKNLKHRFLQQKIYTYAGSILV 184

  Fly    96 AVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTES 160
            |:||::.: .:|.|..:|.|..:.||:|.|||||:||.|...|...:::|.|::|||||:|||:|
Human   185 AINPFKFL-PIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQS 248

  Fly   161 TKYLLKYLCYSHDS--AGPIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGG 223
            |.:|:..|......  |..:|..||.|.|||||||||||..|||||||||||:|.|.....|.|.
Human   249 TNFLIHCLTALSQKGYASGVERTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVSYLESGIVRGA 313

  Fly   224 YISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQ 288
            .:..|||||||:.:|..:||||||||.||.|..::.|.:..|.:|:||.||:
Human   314 VVEKYLLEKSRLVSQEKDERNYHVFYYLLLGVSEEERQEFQLKQPEDYFYLN------------- 365

  Fly   289 LIPGSQKSKNHQQKGPLKDPIIDDYQH-FHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFE 352
                     .|..|  ::|.  :|.:| |..|.:|:..:|.....|..|:::::|:|:|||:.::
Human   366 ---------QHNLK--IEDG--EDLKHDFERLKQAMEMVGFLPATKKQIFAVLSAILYLGNVTYK 417

  Fly   353 EIPDDVRGGCQVSEASEQSLTITSGLLGVDQTELRTALVSR---VMQSKGGGFKGTVIMVPLKIY 414
            :.......|.:|  ...:.|...|.||.|.:..|...|..|   .:..|        :::|..:.
Human   418 KRATGREEGLEV--GPPEVLDTLSQLLKVKREILVEVLTKRKTVTVNDK--------LILPYSLS 472

  Fly   415 EASNARDALAKAIYSRLFDRIVGLIN------QSIPFQASNFYIGVLDIAGFEYFTVNSFEQFCI 473
            ||..|||::||::||.|||.||..||      :.:....|...||||||.|||.|..||||||||
Human   473 EAITARDSMAKSLYSALFDWIVLRINHALLNKKDVEEAVSCLSIGVLDIFGFEDFERNSFEQFCI 537

  Fly   474 NYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKP 538
            ||.||:||.:||.:|.|.|||.|:.||:....|.:|||...|.||..|..|:|.||||||..|
Human   538 NYANEQLQYYFNQHIFKLEQEEYQGEGITWHNIGYTDNVGCIHLISKKPTGLFYLLDEESNFP-- 600

  Fly   539 SYSHFTAEV--------HKSWANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIE 595
               |.|::.        |:.  |.|.||.|..           |..|:::||||.|.|..:.|.|
Human   601 ---HATSQTLLAKFKQQHED--NKYFLGTPVM-----------EPAFIIQHFAGKVKYQIKDFRE 649

  Fly   596 KNNDALHASLEGLVQECDNPLLQTL---------------------------------------- 620
            ||.|.:...:..|::..|:..::.|
Human   650 KNMDYMRPDIVALLRGSDSSYVRELIGMDPVAVFRWAVLRAAIRAMAVLREAGRLRAERAEKAAG 714

  Fly   621 ------------FPSGSST---------------SVRG--------------------------- 631
                        .|.|:||               |::|
Human   715 MSSPGAQSHPEELPRGASTPSEKLYRDLHNQMIKSIKGLPWQGEDPRSLLQSLSRLQKPRAFILK 779

  Fly   632 ------------------KLNFI-----------------------SVGSKFKTQLGELMEKLEQ 655
                              .|..|                       |:.::|:|.|.:|:|.|.:
Human   780 SKGIKQKQIIPKNLLDSKSLKLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGK 844

  Fly   656 NGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPE 720
            ....|||||:.|::..:..|:..|.|.||:.:|.:..:.:...||.::..|.|....::.:||.:
Human   845 AEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDFTEQFQVLLPKD 909

  Fly   721 LVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIR 785
              :.|.|.....:.:.:.:..::::.|.||||.:..:.......:..:         .|:|.|:.
Human   910 --AQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHRE---------VVRKILLL 963

  Fly   786 SRWVKSALGALCVIKLR---------------NRIIYRNKCVLIAQRIARGFLARKQHRPRYQGI 835
            ..|.:..|.....::::               .|.:.|.:..:..|...||:..||.:|.:.|.|
Human   964 QSWFRMVLERRHFLQMKRAAVTIQACWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSI 1028

  Fly   836 GKI--------------------NKIRTNTLKTIEIA-SGLKMGREEIISGVNDIYRQIDDAIK- 878
            .::                    .|......:.:|.| :|.:.|.:...:|...:..|..:..:
Human  1029 IRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAAGGQQVAEQGPEPAED 1093

  Fly   879 --KIKMNPRI-------------------TQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQ 922
              .:...|.:                   .::.:....||...:..|:     ...:|::::..|
Human  1094 GGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKV-----PSSREKRESRRQ 1153

  Fly   923 ERLRKIQ------EALEAERAAKEAEEQRQREE----IENKRLKAEMETR---RKAAE--AQRLR 972
            ..|..::      ::.:.|.|.:|...:..:|:    :|:|:...|.||.   ...||  :|:..
Human  1154 RGLEHVKFQNKHIQSCKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQP 1218

  Fly   973 QEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELAL--RLANESNGQVEDSP-------- 1027
            .|:....|...:.|:.||.....:....|||   |...|||  |::..:.|...::|
Human  1219 TEQPQAMAVGKVSEETEKTLPSGSPRPGQLE---RPTSLALDSRVSPPAPGSAPETPEDKSKPCG 1280

  Fly  1028 -PVIRNGVNDASPMGPNKLISF--SQVVSNIASRYLNKSENVRAQQQALGKQKYDLSK------- 1082
             |.::.  ...||.|..::..:  ::.:::....:..|.....|...|:..|..|||.
Human  1281 SPRVQE--KPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGA 1343

  Fly  1083 --WKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENERAPRSVMEAAFKQ 1145
              ....|.|.:.:||...:||.:..             ||:....||  :.||:.:.
Human  1344 ALTPTEERRTSFSTSDVSKLLPSLA-------------KAQPAAETT--DGERSAKK-------- 1385

  Fly  1146 PPLVQPIQEIVTAQHRYFRIPFMRANAPDNTKRGLW-YAHFDGQWIARQMELHADKPPILLVAGT 1209
             |.||.            :.|...::.||   .||. .:..|.:...:::.||..|.....:.|.
Human  1386 -PAVQK------------KKPGDASSLPD---AGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGA 1434

  Fly  1210 DDMQMC---ELSLEETGLTRKRGAEILEHEFNR------EWERNGGKAYKN 1251
            ::::..   .:.||.|  |.|:|.|....:.:|      ..:..|||..||
Human  1435 EELENAVSGHVVLEAT--TMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKN 1483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	8/42 (19%)
		MYSc_Myo6	71..754	CDD:276833	262/837 (31%)
		CBD_MYO6-like	765..913	CDD:409646	26/205 (13%)
		ERM_helical	<954..1020	CDD:466641	19/72 (26%)
		MYO6_MIU_linker	1002..1093	CDD:480843	22/112 (20%)
		MyUb_Myo6	1076..1116	CDD:439319	10/48 (21%)
		Myosin-VI_CBD	1160..1246	CDD:465157	18/95 (19%)
MYO9B	NP_004136.2	RA_Myosin-IXb	16..112	CDD:340737	12/56 (21%)
		MYSc_Myo9	160..941	CDD:276836	262/837 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	709..734		3/24 (13%)
		Actin-binding. /evidence=ECO:0000305	844..855		5/10 (50%)
		Neck or regulatory domain. /evidence=ECO:0000305	940..1044		15/112 (13%)
		IQCD	972..>1001	CDD:467745	1/28 (4%)
		IQ	1000..1022	CDD:197470	6/21 (29%)
		Tail. /evidence=ECO:0000305	1045..2157		90/490 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1046..1298		45/261 (17%)
		PTZ00121	<1050..1630	CDD:173412	90/485 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1320..1410		26/128 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1455..1484		8/29 (28%)
		C1_Myosin-IXb	1628..1685	CDD:410434
		RhoGAP_myosin_IXB	1698..1883	CDD:239872
		Interaction with RHOA. /evidence=ECO:0000269|PubMed:26529257	1739..1744
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1980..2157
		PHA03307	<1985..>2140	CDD:223039