Protein Alignment jar and MYO9A

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_011519915.1
• Gene: MYO9A / 4649
• HGNCID: 7608
• Length: 2638
• Species: Homo sapiens
• Alignment Length: 1383
• Identity: 359/1383 - (25%)
• Similarity: 568/1383 - (41%)
• Gaps: 415/1383 - (30%)

  Fly    12 DAAEGYIQGRITEIGAKEFEVTPTD------RKYPKR----------------------TCHFDD 48
            |..:.|:...:.|.|.:|:.:.|||      ..:|:.                      :.|:..
Human    56 DKTKCYVLAEVKEFGGEEWILNPTDCPVQRMMLWPRMALENRLSGEDYRFLLREKNLDGSIHYGS 120

  Fly    49 IHS---------------SCDGPQ--DHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIA 96
            :.|               ....||  |.||.|.|..|||.|.|:||:.|:..:||||||.:|||.
Human   121 LQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIV 185

  Fly    97 VNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTEST 161
            :||::.: .:|.|..:|.|:...||:|.||::|:||.|...|...|.:|.|::|||||:|||:||
Human   186 INPFKFL-PIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQST 249

  Fly   162 KYLLKYLCYSHDS--AGPIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGY 224
            .:|:.:|......  |..:|..||.|.|||||||||||..|||||||||||:|:|.....|:|.|
Human   250 NFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAY 314

  Fly   225 ISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQL 289
            :..|||||||:..|...||||||||.|||||.:..|....|.:|::|.||:..|
Human   315 VEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSAFHLKQPEEYHYLNQIT----------- 368

  Fly   290 IPGSQKSKNHQQKGPLKDPIIDDY----------------QH-FHNLDKALGRLGLSDTEKLGIY 337
                        |.||:.. .|||                :| |..|..|:..:|.....:..|:
Human   369 ------------KKPLRQS-WDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIF 420

  Fly   338 SLVAAVLHLGNIAFEE--IPDDVRGGCQVSEASEQSLTITSGLLGVDQTELRTALVSRVMQSKGG 400
            ||::|:||||||.:::  ..||     .:...:.:.|.|.|.||.|.:..|..|||:|...:
Human   421 SLLSAILHLGNICYKKKTYRDD-----SIDICNPEVLPIVSELLEVKEEMLFEALVTRKTVT--- 477

  Fly   401 GFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLIN------QSIPFQASNFYIGVLDIAG 459
              .|..:::|.|:.||...|:::||::||.|||.||..||      :.:........||||||.|
Human   478 --VGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHNTKTLSIGVLDIFG 540

  Fly   460 FEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDIIELIEAKSNG 524
            ||.:..|||||||||:.||:||.:||.:|.|.|||.|:.||::...|.:.||...|.||..|..|
Human   541 FEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTG 605

  Fly   525 IFTLLDEESKLPKPSYSHFTAEV-HKSWANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCY 588
            :..||||||..|:.:......:. |:...|.| :..|...          |..|:::|:||.|.|
Human   606 LLHLLDEESNFPQATNQTLLDKFKHQHEDNSY-IEFPAVM----------EPAFIIKHYAGKVKY 659

  Fly   589 NTEQFIEKNNDAL------------HASLEGLV-------------------------------- 609
            ..:.|.|||.|.:            :|.:.|::
Human   660 GVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVAFREAGKRNIH 724

  Fly   610 -----------------------------------QEC---------DNP--------------- 615
                                               |.|         .||
Human   725 RKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNALNE 789

  Fly   616 ----------------LLQTLFPSGSS---------TSVRGKL------------NF-------- 635
                            :.|:...||:|         .|...||            ||
Human   790 KNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGILTRNKNFKSKPALPK 854

  Fly   636 ---------------------------------ISVGSKFKTQLGELMEKLEQNGTNFIRCIKPN 667
                                             .|:.::|:..|.:|||.|.|....|::||:.|
Human   855 HLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVKCIRSN 919

  Fly   668 SKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPARTFCEA 732
            ::.:..:|...|.|.||:.:|.:..:.:.:.||.|:..|.|..|.:..:||..::  |::...:.
Human   920 AEKLPLRFSDVLVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPRNII--PSKFNIQD 982

  Fly   733 MFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALC 797
            .|:.:||:..:::.|.|.||.:..:......::..:         .:::.::..||.:
Human   983 FFRKINLNPDNYQVGKTMVFLKEQERQHLQDLLHQE---------VLRRIILLQRWFR------- 1031

  Fly   798 VIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEI 862
            |:..|...::..:..:|.||..|.:|.:||.|
Human  1032 VLLCRQHFLHLRQASVIIQRFWRNYLNQKQVR--------------------------------- 1063

  Fly   863 ISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRK 927
                       |.|::|            |:.   |||:...|.           ||..:..|.:
Human  1064 -----------DAAVQK------------DAF---VMASAAALL-----------QASWRAHLER 1091

  Fly   928 IQEALEAERAAKEAEEQRQREEIENKRLKAE-METRRKAAEAQRLRQEEEDRRAALALQEQLEKE 991
             |..||. |||....:|:.|:....:.:.|. ::.|.||....:..||:  |:..:.||... :.
Human  1092 -QRYLEL-RAAAIVIQQKWRDYYRRRHMAAICIQARWKAYRESKRYQEQ--RKKIILLQSTC-RG 1151

  Fly   992 AKDDAKYRQQLEQERRDHELALRLAN-ESNG--QVEDSPPVIRNGVNDASPMGPNKLISFSQVVS 1053
            .:...:::...||..|:.:..:.|.| :..|  :::.|.|   :|..|.|  ..|::.:..:..|
Human  1152 FRARQRFKALKEQRLRETKPEVGLVNIKGYGSLEIQGSDP---SGWEDCS--FDNRIKAIEECKS 1211

  Fly  1054 NIASRYLNKSENVRAQQQALGKQKYDLSKWKYSELRDAINTSCDIELLEACR--QEFHRRLKVYH 1116
            .|.|..:::..:|...:::..||:      :.::.:..::...|:.:.|..|  ::.|:: ||..
Human  1212 VIESNRISRESSVDCLKESPNKQQ------ERAQSQSGVDLQEDVLVRERPRSLEDLHQK-KVGR 1269

  Fly  1117 AWKAKNRKRTTMDENERA 1134
            |.:...|.|    |.|:|
Human  1270 AKRESRRMR----ELEQA 1283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/64 (16%)
		MYSc_Myo6	71..754	CDD:276833	268/891 (30%)
		CBD_MYO6-like	765..913	CDD:409646	20/147 (14%)
		ERM_helical	<954..1020	CDD:466641	14/67 (21%)
		MYO6_MIU_linker	1002..1093	CDD:480843	18/93 (19%)
		MyUb_Myo6	1076..1116	CDD:439319	7/41 (17%)
		Myosin-VI_CBD	1160..1246	CDD:465157
MYO9A	XP_011519915.1	RA_Myosin-IXa	15..110	CDD:340736	9/53 (17%)
		MYSc_Myo9	160..1004	CDD:276836	268/891 (30%)
		C1_Myosin-IXa	2067..2124	CDD:410433
		RhoGAP_myosin_IX	2133..2318	CDD:239842