Protein Alignment jar and MYO7A

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_011543348.2
• Gene: MYO7A / 4647
• HGNCID: 7606
• Length: 2258
• Species: Homo sapiens
• Alignment Length: 1227
• Identity: 371/1227 - (30%)
• Similarity: 554/1227 - (45%)
• Gaps: 258/1227 - (21%)

  Fly    40 PKRTCHFDDIH-SSCDGPQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREI 103
            |:...|...:| :|..|.   :|...|..||||..|.||..||....||||..:||:||||| ::
Human    80 PQNATHIKPMHPTSVHGV---EDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPY-QL 140

  Fly   104 KELYAPDTIKKYNGRSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYL 168
            ..:|:|:.|::|..:.:||:|||:|||||....:|:.....|..|:|||||||||||||.:|::|
Human   141 LSIYSPEHIRQYTNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFL 205

  Fly   169 CYSHDSAGPIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKS 233
            .........||.::|:|.|:|||||||||.||:|||||||:|::|::.:..:.|..|..||||||
Human   206 AAISGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKS 270

  Fly   234 RICTQSAEERNYHVFYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKN 298
            |:|.|:.:||||||||.:|.|..:..:.||.||:..||.||:     ..|..|
Human   271 RVCRQALDERNYHVFYCMLEGMSEDQKKKLGLGQASDYNYLA-----MGNCIT------------ 318

  Fly   299 HQQKGPLKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQ 363
              .:|.:      |.|.:.|:..|:..|..:|||...|..|:||:|||||:.:|....:....|:
Human   319 --CEGRV------DSQEYANIRSAMKVLMFTDTENWEISKLLAAILHLGNLQYEARTFENLDACE 375

  Fly   364 VSEASEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIY 428
            |  ....||...:.||.|:..:|.:.|.||.:.:     :|..:..||...:|.:.|||..|.||
Human   376 V--LFSPSLATAASLLEVNPPDLMSCLTSRTLIT-----RGETVSTPLSREQALDVRDAFVKGIY 433

  Fly   429 SRLFDRIVGLINQSI---PFQ---ASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDN 487
            .|||..||..||.:|   |.|   .|...||:|||.|||.|.||||||.|||:.||.||:||..:
Human   434 GRLFVWIVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSFEQLCINFANEHLQQFFVRH 498

  Fly   488 ILKNEQELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPK---PSYSHFTAEVHK 549
            :.|.|||.|..|.::...|.||||||.:::|..|...|.:|:|||||.||   .:..|.....||
Human   499 VFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDEESKFPKGTDTTMLHKLNSQHK 563

  Fly   550 SWANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDN 614
            ..||:..   |:::.         |..|.:.||||.|.|.|:.|:|||.|.||..:..||....|
Human   564 LNANYIP---PKNNH---------ETQFGINHFAGIVYYETQGFLEKNRDTLHGDIIQLVHSSRN 616

  Fly   615 PLLQTLFPSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSL 679
            ..::.:|.:..:.....:....::.|:||..|..||..|......|:||||||.......|:..|
Human   617 KFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDRHL 681

  Fly   680 ALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLP---PELVSLPARTFCEAMFQSLNLSA 741
            .:.||:.||.:..:.:...|||.|..|.:....|:.:||   |.......|..|:.|.:::..:.
Human   682 CVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQGDLRGTCQRMAEAVLGTH 746

  Fly   742 KDFKFGITKVFFR---------------PGKFVEFDRIMR--SDPENMLAIVAKVKKWLIRSRW- 788
            .|::.|.||:|.:               ..:.:...:::|  .|..|.|.:  |....||:..|
Human   747 DDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKDRSNFLKL--KNAATLIQRHWR 809

  Fly   789 -----VKSALGALCVIKL----------------RNRII-YRNKC---------------VLIAQ 816
                 ....|..|..::|                |.||| ::.:|               ||..|
Human   810 GHNCRKNYGLMRLGFLRLQALHRSRKLHQQYRLARQRIIQFQARCRAYLVRKAFRHRLWAVLTVQ 874

  Fly   817 RIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKIK 881
            ..|||.:||:.|:          ::|...|..:| |..:::..||.:
Human   875 AYARGMIARRLHQ----------RLRAEYLWRLE-AEKMRLAEEEKL------------------ 910

  Fly   882 MNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQ 946
                  ::||.:                 .|.||:.:.:.||||.::... :|||..||.|..|:
Human   911 ------RKEMSA-----------------KKAKEEAERKHQERLAQLARE-DAERELKEKEAARR 951

  Fly   947 REEIENKRLKAEMETRRKA---------------------------AEAQRLRQE--EEDRRAAL 982
            ::|:..:..:|..|....:                           .:.:|.|:|  |||..|||
Human   952 KKELLEQMERARHEPVNHSDMVDKMFGFLGTSGGLPGQEGQAPSGFEDLERGRREMVEEDLDAAL 1016

  Fly   983 ALQEQLEKEAKD--DAKYRQQLEQERRDHELALR------LANESNGQ--------------VED 1025
            .|.::.|::..:  .||:.....|....|....|      |.::..|.              :.|
Human  1017 PLPDEDEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGD 1081

  Fly  1026 SP-PVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQKYDLSKWKYSELR 1089
            .| |.....::|.|...|        |::.|              .:.|||:.|.      .||:
Human  1082 LPEPKYHTAMSDGSEKIP--------VMTKI--------------YETLGKKTYK------RELQ 1118

  Fly  1090 DAINTSCDIELLEACRQEFHRRLKVYHAWKAKNR------KRTTMDENERAPRSVME 1140
             |:....:.:|.|..::...|...|:...|.|::      ||....|:.....|::|
Human  1119 -ALQGEGEAQLPEGQKKSSVRHKLVHLTLKKKSKLTEEVTKRLHDGESTVQGNSMLE 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	2/8 (25%)
		MYSc_Myo6	71..754	CDD:276833	267/694 (38%)
		CBD_MYO6-like	765..913	CDD:409646	33/187 (18%)
		ERM_helical	<954..1020	CDD:466641	19/102 (19%)
		MYO6_MIU_linker	1002..1093	CDD:480843	20/111 (18%)
		MyUb_Myo6	1076..1116	CDD:439319	8/39 (21%)
		Myosin-VI_CBD	1160..1246	CDD:465157
MYO7A	XP_011543348.2	MYSc_Myo7	109..759	CDD:276832	267/694 (38%)
		CBD_MYO6-like	<796..>839	CDD:409646	7/44 (16%)
		tolA	<826..>996	CDD:236545	40/222 (18%)
		MAP7	<887..963	CDD:461709	23/128 (18%)
		MyTH4	1047..1283	CDD:214535	29/157 (18%)
		FERM1_F1_Myosin-VII	1287..1385	CDD:340612
		B41	1289..1504	CDD:214604
		FERM_C1_MyoVII	1498..1634	CDD:270019
		SH3	1635..1699	CDD:473055
		MyTH4	1793..1926	CDD:214535
		FERM2_F1_Myosin-VII	1931..2028	CDD:340613
		B41	1933..2145	CDD:214604