DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and MYO6

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001355794.1	Gene:	MYO6 / 4646	HGNCID:	7605	Length:	1294	Species:	Homo sapiens

Alignment Length:	1313	Identity:	666/1313 - (50%)
Similarity:	895/1313 - (68%)	Gaps:	72/1313 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LEDTQLVWVRDAAEGYIQGRITEIGAKEFEVTPTDRK-----------YPKRTCHFDDIHSSCDG 55
            :||.:.||.....:|:..|.|.:||.....:.|.::|           :|...          |.
Human     1 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEE----------DS 55

  Fly    56 PQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSL 120
            .:|.:|||.||.|||||.|.|:|.||.||:|||||||||||||||.:|.::|:.:.||.|.|:||
Human    56 KKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL 120

  Fly   121 GELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETKILDA 185
            |..|||||||||||.|||:|.|:||||||||||||||||:||::|:||..|:.:...|:.:|::|
Human   121 GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDDRIVEA 185

  Fly   186 NPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYM 250
            ||:|||||||||.|||||||||||:|:|::.|..||||::|||||||||||.|..||||||:||.
Human   186 NPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYR 250

  Fly   251 LLAGAPQQLRDKLSLGKPDDYRYLS-GCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQ 314
            |.|||.:.:|:||.|..||::|||: |||:||||.:|::.|..::||..:.:.|.:|||::||:.
Human   251 LCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHG 315

  Fly   315 HFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLL 379
            .|..:..|:.::||.|.|||.::.:||.|||||||.||| .....|||.:...|.|||...:.||
Human   316 DFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEE-AGSTSGGCNLKNKSAQSLEYCAELL 379

  Fly   380 GVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIP 444
            |:||.:||.:|.:|||.:..||.|||||.||||:.:|:||||||||.:||.|||.:|..:||..|
Human   380 GLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFP 444

  Fly   445 FQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFT 509
            |:.|:::||||||||||||..||||||||||||||||:|||:.|||.|||||::|||.|.|:.:.
Human   445 FETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYV 509

  Fly   510 DNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDE 574
            ||||.|:|||||..||..:||||::||:||..|||:.||:...:|:||.:||.|:|..||.:||:
Human   510 DNQDCIDLIEAKLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDD 574

  Fly   575 EGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTS-----VRGKLN 634
            |||::|||||||||.|.||:||||||||.|||.|:.|..:..::.||.|.::.:     ..|||:
Human   575 EGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLS 639

  Fly   635 FISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHG 699
            |||||:||||||..|::||...|.:||||||||.||....|||:..|:||:|||.:|||:||:.|
Human   640 FISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGG 704

  Fly   700 YPSRVLFADLYSMYKSVLPPELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRI 764
            ||||..|.:||:|||..:|.:|..|..|.||:|:|::|.|:..|:|||:||||||||||.|||:|
Human   705 YPSRASFHELYNMYKKYMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQI 769

  Fly   765 MRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHR 829
            |:|||:::..:|.:|..||..|||.|....:|.||||:|:|.||.:..:..|:..|.:|.:::|:
Human   770 MKSDPDHLAELVKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHK 834

  Fly   830 PRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSM 894
            ||..|:.|:..::....|..|:.|.||.|:.|:...:.::...||..:.||| :..:||.::...
Human   835 PRIDGLVKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIK-STMMTQEQIQKE 898

  Fly   895 YTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEM 959
            |..::.:..:|   |:...|::||.||.||||:|||.:|.||..:|.:|:|:|:|.|.:|:|.||
Human   899 YDALVKSSEEL---LSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM 960

  Fly   960 ETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLA-------- 1016
            |.:||..|.:|.::|::::|....::.||.::.:::::.:..|||||||.|||||:|
Human   961 EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSEAELIS 1025

  Fly  1017 NESNGQVE----DSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQK 1077
            :|:...:.    ||.||..........|.|.::       :...|.:|::...|.|.:.|.|.:|
Human  1026 DEAQADLALRSLDSYPVTSKNDGTRPKMTPEQM-------AKEMSEFLSRGPAVLATKAAAGTKK 1083

  Fly  1078 YDLSKWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENERAPRSVMEAA 1142
            ||||||||:||||.||||||||||.|||:|||||||||||||:||:||.|..| :|||:||.:..
Human  1084 YDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETE-QRAPKSVTDYD 1147

  Fly  1143 F----KQPPLVQPIQEI--------VTAQHRYFRIPFMRA----NAPDNTKRGLWYAHFDGQWIA 1191
            |    ...|...|..:|        :..|.|:|||||:|.    ..|.:.|:|.|||||||.|||
Human  1148 FAPFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGPWIA 1212

  Fly  1192 RQMELHADKPPILLVAGTDDMQMCELSLEETGLTRKRGAEILEHEFNREWERNGGKAYKNLG--- 1253
            ||||||.||||||||||.|||:||||:|||||||||||||||..:|...|||.||..|....
Human  1213 RQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQYLQNAIES 1277

  Fly  1254 -AAKPNGPAAAMQ 1265
             .|:|....|.:|
Human  1278 RQARPTYATAMLQ 1290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832	10/48 (21%)
		Myosin_head	59..754	CDD:278492	412/700 (59%)
		MYSc_Myo6	71..754	CDD:276833	404/688 (59%)
		RILP-like	<968..1015	CDD:304877	16/46 (35%)
		Myosin-VI_CBD	1160..1246	CDD:293129	62/89 (70%)
MYO6	NP_001355794.1	MYSc_Myo6	71..759	CDD:276833	404/688 (59%)
		Responsible for slow ATPase activity. /evidence=ECO:0000250\|UniProtKB:Q29122	273..317		19/43 (44%)
		Actin-binding. /evidence=ECO:0000255	665..672		6/6 (100%)
		Required for binding calmodulin. /evidence=ECO:0000250\|UniProtKB:Q29122	782..810		13/27 (48%)
		SMC_prok_B	<800..>1039	CDD:274008	82/242 (34%)
		Three-helix bundle. /evidence=ECO:0000250\|UniProtKB:Q29122	835..916		21/84 (25%)
		SAH. /evidence=ECO:0000269\|PubMed:18511944	917..984		31/66 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	934..955		9/20 (45%)
		Interaction with OPTN. /evidence=ECO:0000250\|UniProtKB:Q9I8D1	1116..1118		1/1 (100%)
		Myosin-VI_CBD	1177..1267	CDD:339762	62/89 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145798
Domainoid	1	1.000	854	1.000	Domainoid score	I59
eggNOG	1	0.900	-	-		E2759_KOG0163
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56417
Inparanoid	1	1.050	1287	1.000	Inparanoid score	I163
Isobase	1	0.950	-	0	Normalized mean entropy	S1622
OMA	1	1.010	-	-		QHG59165
OrthoDB	1	1.010	-	-		D112896at33208
OrthoFinder	1	1.000	-	-		FOG0005395
OrthoInspector	1	1.000	-	-		oto89063
orthoMCL	1	0.900	-	-		OOG6_105053
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4674
SonicParanoid	1	1.000	-	-		X3827
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750