Protein Alignment jar and MYO5A

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001369277.1
• Gene: MYO5A / 4644
• HGNCID: 7602
• Length: 1904
• Species: Homo sapiens
• Alignment Length: 1439
• Identity: 393/1439 - (27%)
• Similarity: 647/1439 - (44%)
• Gaps: 305/1439 - (21%)

  Fly     2 LEDTQL----VWVRDAAE---------GYIQG------RITEIGAKEFEVTPTDRKYPKRTCHFD 47
            |::|.|    ||:.|..|         .|..|      .:.|....|:.:.|..::.|    |.
Human    27 LDETALKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELP----HL- 86

  Fly    48 DIHSSCDGPQDHDDNCELMLLNEATFLDNLKTRYYKDK-IYTYVANILIAVNPYREIKELYAPDT 111
               .:.|.....:|...|..|:|...|.||:.|:...| ||||...:|:|:|||.:: .:|..|.
Human    87 ---RNPDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQL-PIYGEDI 147

  Fly   112 IKKYNGRSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAG 176
            |..|:|:::|::.||:||:|::|.:.|...:.:||||||||||||||.|.||.::|......||.
Human   148 INAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSAS 212

  Fly   177 P--IETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQS 239
            .  :|.|:|.:||::|:.||||||||:|||||||:||:.:|.:.:::|..:..|||||||:..|:
Human   213 EANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQA 277

  Fly   240 AEERNYHVFYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGP 304
            .||||||:||.|.|.|.......|.||..|::.|            |:|  .||
Human   278 EEERNYHIFYQLCASAKLPEFKMLRLGNADNFNY------------TKQ--GGS----------- 317

  Fly   305 LKDPII---DDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSE 366
               |:|   ||.:...:..:|...||:|::.::||:.::|.:|||||:.|.....|   .|.:..
Human   318 ---PVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDAD---SCTIPP 376

  Fly   367 ASEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRL 431
            ..| .|.|...|:|||..|:...|..|.:.:....:     :.|:...:|:||||||||.||::|
Human   377 KHE-PLCIFCELMGVDYEEMCHWLCHRKLATATETY-----IKPISKLQATNARDALAKHIYAKL 435

  Fly   432 FDRIVGLINQSIPFQA-SNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQEL 495
            |:.||..:||::.... .:.:||||||.|||.|.:||||||||||.|||||:.||.::.|.|||.
Human   436 FNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEE 500

  Fly   496 YKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLP 560
            |.:|.:....|.|.|||..|.|||:|. ||..|||||.|:||.:...:..:::.:..|  :..|.
Human   501 YMKEQIPWTLIDFYDNQPCINLIESKL-GILDLLDEECKMPKGTDDTWAQKLYNTHLN--KCALF 562

  Fly   561 RSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF---- 621
            ...||       ..:.|:::|||..|.|..|.|:|||.|.:......:::.....:|..||
Human   563 EKPRL-------SNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDE 620

  Fly   622 ----PSGSSTSVR------------------GKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCI 664
                |:.:::|.|                  .|.:..:||.:|:..|..|||.|.....:::|||
Human   621 KAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCI 685

  Fly   665 KPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPARTF 729
            |||.......|:...|:.||:..|.:..:.:...|:|||..:.:.:|.|:.::..:.|....:..
Human   686 KPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLSDRKQT 750

  Fly   730 CEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKK----WLIRSRWVK 790
            |:.:.:.|.|....::||.||:|||.|:....:: :|:|  .:.|...:::|    ||:|.::::
Human   751 CKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEK-LRAD--KLRAACIRIQKTIRGWLLRKKYLR 812

  Fly   791 SALGAL------------CVIK-------------------LRNRIIYRNKCVLIAQRIARGFLA 824
            ....|:            |..|                   :|.|...|....::.|...|||||
Human   813 MRKAAITMQRYVRGYQARCYAKFLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLA 877

  Fly   825 RKQHRP--------------------------------------RYQGIGKINKIRTNTLKTIEI 851
            |.::|.                                      |.....::.|::... :::|.
Human   878 RNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMMAKRELKKLKIEA-RSVER 941

  Fly   852 ASGLKMGREEIISGVNDIYRQIDDAIKKIK-MNPRITQREMDSMYTVVMANMNKLTVDLNTKLKE 915
            ...|.:|.|   :.:..:.|::|:..|..| :..::|  .::.:|       |..|..|.:.|:.
Human   942 YKKLHIGME---NKIMQLQRKVDEQNKDYKCLVEKLT--NLEGIY-------NSETEKLRSDLER 994

  Fly   916 QQQAEE------------QERLRKIQEALEAERAAKEAEEQ---RQREEIEN--KRLKAEMETRR 963
            .|.:||            ||.:.|:::.||..|:.|:..|:   |.::|.|.  ..||.|....:
Human   995 LQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLK 1059

  Fly   964 KAAEAQRLRQEEEDRRAALALQEQLEKEAK------DDAKYRQQ--------LEQERRD--HELA 1012
            :..||...|..::.:.....::::|.:|.|      :|.:.|.|        ||:...|  .|:.
Human  1060 QEKEALNHRIVQQAKEMTETMEKKLVEETKQLELDLNDERLRYQNLLNEFSRLEERYDDLKEEMT 1124

  Fly  1013 LRL---------------ANESN-------GQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNI 1055
            |.:               :|||.       .::||.|...........|:..:..:...:.|:.:
Human  1125 LMVHVPKPGHKRTDSTHSSNESEYIFSSEIAEMEDIPSRTEEPSEKKVPLDMSLFLKLQKRVTEL 1189

  Fly  1056 -ASRYLNKSENVRAQQQALGKQKYDLSKWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWK 1119
             ..:.:.:.|..|.::|.|      .||.|..|.........:.|.|:  |||.          :
Human  1190 EQEKQVMQDELDRKEEQVL------RSKAKEEERPQIRGAELEYESLK--RQEL----------E 1236

  Fly  1120 AKNRK-RTTMDENERA--PRSVMEAAFKQPPLVQPIQEIVTA-----QHRYFRIPFMR------- 1169
            ::|:| :..::|..:|  .:|..|......|..:.:.|.:|:     ..|...:..:|
Human  1237 SENKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLTSVSEELDVRKEEVLILRSQLVSQK 1301

  Fly  1170 -ANAPDNTKRGLWYAHFDGQWIARQMELHADKPPILLVAGTDDMQMCELSLEETGLTRKRGAEIL 1233
             |..|.:.|..:    .|...:...::...||         .::....:.|:||    .|.:.:.
Human  1302 EAIQPKDDKNTM----TDSTILLEDVQKMKDK---------GEIAQAYIGLKET----NRSSALD 1349

  Fly  1234 EHEFNREWE 1242
            .||.|.:.|
Human  1350 YHELNEDGE 1358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	12/60 (20%)
		MYSc_Myo6	71..754	CDD:276833	257/715 (36%)
		CBD_MYO6-like	765..913	CDD:409646	36/221 (16%)
		ERM_helical	<954..1020	CDD:466641	19/96 (20%)
		MYO6_MIU_linker	1002..1093	CDD:480843	21/115 (18%)
		MyUb_Myo6	1076..1116	CDD:439319	9/39 (23%)
		Myosin-VI_CBD	1160..1246	CDD:465157	16/91 (18%)
MYO5A	NP_001369277.1	COG5022	35..1472	CDD:227355	390/1431 (27%)
		MYSc_Myo5	107..775	CDD:276831	257/715 (36%)
		Myo5a_CBD	1530..1904	CDD:271262