DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and MYO1D

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_056009.1	Gene:	MYO1D / 4642	HGNCID:	7598	Length:	1006	Species:	Homo sapiens

Alignment Length:	1227	Identity:	331/1227 - (26%)
Similarity:	517/1227 - (42%)	Gaps:	316/1227 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 FLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADKAIRD 137
            |:.||:.|:.|.:|||::..::::||||: :..:|..|||::|.||.|.|.|||:|||||.|.:.
Human    25 FMANLRLRFEKGRIYTFIGEVVVSVNPYK-LLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKA 88

  Fly   138 MRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETK-----ILDANPVLEAFGNAKT 197
            |:.......|::||||||||||::||:::|:....:.:...|.:     :|.:|.||||||||||
Human    89 MKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKT 153

  Fly   198 TRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLRDK 262
            .||:|||||||::::::|.|...:||:|::|||||||:..|...||::|.||.||.|..:|:...
Human   154 NRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQGGSEQMLRS 218

  Fly   263 LSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALGRLG 327
            |.|.|                         |..|.|:...|......|:|...|..:..|:..:|
Human   219 LHLQK-------------------------SLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIG 258

  Fly   328 LSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTELRTALVS 392
            ....|...:|.::||:|||||:.|.     |.|...:.| :.:.::|.:.||......:..||:.
Human   259 FKPEEIQTVYKILAAILHLGNLKFV-----VDGDTPLIE-NGKVVSIIAELLSTKTDMVEKALLY 317

  Fly   393 RVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSI-------PFQASNF 450
            |.:.:     ...:|.......|||..|||.|||||.|||..||..||..|       .....|.
Human   318 RTVAT-----GRDIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNT 377

  Fly   451 YIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDII 515
            .||||||.|||.|..||||||||||||||||:.|...:||.|||.|:|||:....|.:.:||.|:
Human   378 VIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIV 442

  Fly   516 ELIEAKSNGIFTLLDE-----------------ESKLPKPSYSHFTAEVHKSWANHYRLGLPRSS 563
            :|:|.:..||..:||:                 .|||.|  ::||                  ||
Human   443 DLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKLGK--HAHF------------------SS 487

  Fly   564 R--LKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSS 626
            |  ..:.:.|..:..|.:||:||.|.|:...||:||.|.|....:.|:....||:|:.::|.|..
Human   488 RKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKL 552

  Fly   627 TSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTIS 691
            :........::..:.||..:..|::.|......::||||||.|...:.|:......|::..|.:.
Human   553 SITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLE 617

  Fly   692 VLELMEHGYPSRVLFADLYSMYKSV---------LPPELVSLPARTFCEAMFQSLNLSAKDFKFG 747
            .:.:...|:..|..:......||.:         ||.:..:: .:......||.      |..:|
Human   618 NVRVRRAGFAFRQTYEKFLHRYKMISEFTWPNHDLPSDKEAV-KKLIERCGFQD------DVAYG 675

  Fly   748 ITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCV 812
            .||:|.|             .|..:..:.                       :||.:::.|  .|
Human   676 KTKIFIR-------------TPRTLFTLE-----------------------ELRAQMLIR--IV 702

  Fly   813 LIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGRE-EIISGVNDIYRQIDDA 876
            |..|::.||.|||.:::            ||....||     ::..|. ::.|.::::.|:. ..
Human   703 LFLQKVWRGTLARMRYK------------RTKAALTI-----IRYYRRYKVKSYIHEVARRF-HG 749

  Fly   877 IKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEA 941
            :|        |.|:..                     |..:.....:.||:.:|||:.
Human   750 VK--------TMRDYG---------------------KHVKWPSPPKVLRRFEEALQT------- 778

  Fly   942 EEQRQREEIENKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQER 1006
                    |.|:...:::   .|:..|..|.|.    ||.:|..|.|:.:..|
Human   779 --------IFNRWRASQL---IKSIPASDLPQV----RAKVAAVEMLKGQRAD------------ 816

  Fly  1007 RDHELALRLANESN--GQVEDSPPVIRNGVNDASPMG-----PNKLIS--------FSQVVSN-- 1054
                |.|:.|.|.|  ....|:|......|..|:.:.     .|.|.|        ||:|...
Human   817 ----LGLQRAWEGNYLASKPDTPQTSGTFVPVANELKRKDKYMNVLFSCHVRKVNRFSKVEDRAI 877

  Fly  1055 -IASRYLNKSENVRAQQQALGKQKYDLSKWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAW 1118
             :..|:|.|.:..:..:.......|:|:....|..:|                    :|.|:|
Human   878 FVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSVSNGKD--------------------QLVVFH-- 920

  Fly  1119 KAKNRKRTTMDENERAPRSVMEAAF-KQPPLVQPIQEIVTAQHRYFRIPFMRANAPDNTKRGLWY 1182
                    |.|.     :.::...| |||.....|.|:|                      |:..
Human   921 --------TKDN-----KDLIVCLFSKQPTHESRIGELV----------------------GVLV 950

  Fly  1183 AHFDGQWIARQMELHADKPPILLVAGTDDMQMCELSLE------ETGLTRKRGAEIL 1233
            .||..:  .|.::::...|....:.|    :.|.:|:|      :...|:.|...||
Human   951 NHFKSE--KRHLQVNVTNPVQCSLHG----KKCTVSVETRLNQPQPDFTKNRSGFIL 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	243/720 (34%)
		MYSc_Myo6	71..754	CDD:276833	243/720 (34%)
		RILP-like	<968..1015	CDD:304877	11/46 (24%)
		Myosin-VI_CBD	1160..1246	CDD:293129	13/80 (16%)
MYO1D	NP_056009.1	MYSc	4..694	CDD:214580	245/768 (32%)
		MYSc_Myo1	24..682	CDD:276829	243/720 (34%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	572..594		7/21 (33%)
		Myosin_TH1	803..997	CDD:283635	48/272 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920