DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and MYO1C

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001074248.1	Gene:	MYO1C / 4641	HGNCID:	7597	Length:	1063	Species:	Homo sapiens

Alignment Length:	1126	Identity:	331/1126 - (29%)
Similarity:	529/1126 - (46%)	Gaps:	207/1126 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 AKEFEVTPTDR----KYPKRTCHF----DDIHSSCD---------GPQDHDDNCELMLL----NE 70
            |.:.|:.||..    .:|.|.|..    |.:..:.:         |.||      .:||    :|
Human     2 ALQVELVPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQD------FVLLENFTSE 60

  Fly    71 ATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADKAI 135
            |.|::||:.|:.::.||||:..:|::|||||:: ::|:...:::|.|.|..|:|||:||:||...
Human    61 AAFIENLRRRFRENLIYTYIGPVLVSVNPYRDL-QIYSRQHMERYRGVSFYEVPPHLFAVADTVY 124

  Fly   136 RDMRVYKLSQSIIVSGESGAGKTESTKYLLKY---LCYSHDSAGPIETKILDANPVLEAFGNAKT 197
            |.:|..:..|::::||||||||||:||.||::   .|.:.:..|.:..::|.:||||||||||||
Human   125 RALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKT 189

  Fly   198 TRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLRDK 262
            .||:|||||||:::|.:|.|...|||:|..|||||||:..|:..|||:|:||.||.|..::...:
Human   190 LRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRR 254

  Fly   263 LSLGK-PDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGP-LKDPIIDDYQHFHNLDKALGR 325
            |.|.: |..|.||                          .||. .|...|:|...:..:.|||..
Human   255 LGLERNPQSYLYL--------------------------VKGQCAKVSSINDKSDWKVVRKALTV 293

  Fly   326 LGLSDTEKLGIYSLVAAVLHLGNIAF---EEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTELR 387
            :..::.|...:.|:||:|||||||.|   ||      ...||:  :|..|...:.||.|:.:.||
Human   294 IDFTEDEVEDLLSIVASVLHLGNIHFAANEE------SNAQVT--TENQLKYLTRLLSVEGSTLR 350

  Fly   388 TALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSI-------PF 445
            .||..|.:.:     ||..::.||.:.:|:.||||||||:|||.|..:||.||:|:       |.
Human   351 EALTHRKIIA-----KGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPS 410

  Fly   446 QASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTD 510
            ..|...:|:|||.|||.|..||||||||||||||||:.|.:..||:|||.|:.||:....:.:.:
Human   411 WRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFN 475

  Fly   511 NQDIIELIEAKSNGIFTLLDEESKLPKPS---------------YSHFTAEVHKSWANHYRLGLP 560
            |:.|.:|:|.|..||.::||||...|..:               :.||.  .||......|..|.
Human   476 NKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFL--THKLADQRTRKSLG 538

  Fly   561 RSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGS 625
            |..             |.:.|:||.|.|:...|::||||.|..:|:..:....||::...|   .
Human   539 RGE-------------FRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCF---D 587

  Fly   626 STSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTI 690
            .:.:..|....:|.::||..|.:|:|.|:.....::||||||......:|:..|...|:|..|.:
Human   588 RSELSDKKRPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLL 652

  Fly   691 SVLELMEHGYPSRVLFADLYSMYKSVLP---PELVSLPARTFCEAMFQSLNLSAKDFKFGITKVF 752
            ..|.:...|:..|..:......|||:.|   |.....| :.....:.:.|....:::|.|.||:|
Human   653 ENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRP-QDGVAVLVRHLGYKPEEYKMGRTKIF 716

  Fly   753 FRPGK--FVEFD--RIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKL------RNRIIY 807
            .|..|  |...|  .:.|......:....:...|  |.::::....|:|:...      |.:...
Human   717 IRFPKTLFATEDALEVRRQSLATKIQAAWRGFHW--RQKFLRVKRSAICIQSWWRGTLGRRKAAK 779

  Fly   808 RNKCVLIAQRIARGFLARKQHRPRY-QGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYR 871
            |.......:|:.|||:.|  |.||. :....::.:||:.|
Human   780 RKWAAQTIRRLIRGFVLR--HAPRCPENAFFLDHVRTSFL------------------------- 817

  Fly   872 QIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEAL--EA 934
                    :.:..::.|..:|:.:.              |.....::|.|..|...|:..:  ..
Human   818 --------LNLRRQLPQNVLDTSWP--------------TPPPALREASELLRELCIKNMVWKYC 860

  Fly   935 ERAAKEAEEQRQREEIENKRLKAEMETRRKAAE----AQRLRQEEEDRRAALALQEQLEKEAKDD 995
            ...:.|.::|.|::.:.::..|.:.:...::..    :.||..:|...|...||..:..:.|...
Human   861 RSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQALGSEPIQYAVPV 925

  Fly   996 AKY-RQQLEQERRDHELALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRY 1059
            .|| |:..:...|.    |.|...:...|||:.  ::..::.|:..|    ||.|.:..::...:
Human   926 VKYDRKGYKPRSRQ----LLLTPNAVVIVEDAK--VKQRIDYANLTG----ISVSSLSDSLFVLH 980

  Fly  1060 LNKSENVRAQQQALGKQKYDL 1080
            :.:::|         |||.|:
Human   981 VQRADN---------KQKGDV 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832	6/21 (29%)
		Myosin_head	59..754	CDD:278492	261/731 (36%)
		MYSc_Myo6	71..754	CDD:276833	258/715 (36%)
		RILP-like	<968..1015	CDD:304877	12/47 (26%)
		Myosin-VI_CBD	1160..1246	CDD:293129
MYO1C	NP_001074248.1	MYSc	43..731	CDD:214580	268/752 (36%)
		MYSc_Myo1	62..718	CDD:276829	257/714 (36%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	608..630		9/21 (43%)
		IQ	756..776	CDD:197470	3/19 (16%)
		Myosin_TH1	874..1041	CDD:283635	27/138 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920