DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and MYO1A

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001242970.1	Gene:	MYO1A / 4640	HGNCID:	7595	Length:	1043	Species:	Homo sapiens

Alignment Length:	1122	Identity:	327/1122 - (29%)
Similarity:	529/1122 - (47%)	Gaps:	197/1122 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ELMLLN---EATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPP 125
            :|:||.   |.:.|.||:.||...:||||:.|::|:||||::: .:|.|:.|.||...:..||.|
Human    12 DLVLLEPLVEESLLKNLQLRYENKEIYTYIGNVVISVNPYQQL-PIYGPEFIAKYQDYTFYELKP 75

  Fly   126 HVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKY---LCYSHDSAGPIETKILDANP 187
            |::|:|:.|.:.:|.....|.|:::||||:||||::|.::.|   :|...:....::.::|.:||
Human    76 HIYALANVAYQSLRDRDRDQCILITGESGSGKTEASKLVMSYVAAVCGKGEQVNSVKEQLLQSNP 140

  Fly   188 VLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLL 252
            ||||||||||.||||||||||::::.:|.|...:||.|::|||||||:..|...|||:|:||.||
Human   141 VLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRLVKQLKGERNFHIFYQLL 205

  Fly   253 AGAPQQLRDKLSLGK-PDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHF 316
            |||.:||...|.|.: ...|.||                       ||:..   :...:||...|
Human   206 AGADEQLLKALKLERDTTGYAYL-----------------------NHEVS---RVDGMDDASSF 244

  Fly   317 HNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEE------IP-DDVRGGCQVSEASEQSLTI 374
            ..:..|:..:|.|:.|...:..:.:.||.|||:...:      || ..:|.|..|.|..|
Human   245 RAVQSAMAVIGFSEEEIRQVLEVTSMVLKLGNVLVADEFQASGIPASGIRDGRGVREIGE----- 304

  Fly   375 TSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLI 439
               ::|::..|:..||.||.|::.    |..|: ..|.:.:|..|||||||.|||||||.||..|
Human   305 ---MVGLNSEEVERALCSRTMETA----KEKVV-TALNVMQAQYARDALAKNIYSRLFDWIVNRI 361

  Fly   440 NQSIP--FQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLN 502
            |:||.  .......:|||||.|||....||||||.|||||||||:.|.:..||.|||.|||||:.
Human   362 NESIKVGIGEKKKVMGVLDIYGFEILEDNSFEQFVINYCNEKLQQVFIEMTLKEEQEEYKREGIP 426

  Fly   503 VPEITFTDNQDIIELIEAKSNGIFTLLDEESKLP-KPSYSHFTAEVHKSWA--NHYRLGLPRSSR 564
            ..::.:.||..|.:|||....||..:||||...| ..|.|.|.|::::.::  .||...:.::::
Human   427 WTKVDYFDNGIICKLIEHNQRGILAMLDEECLRPGVVSDSTFLAKLNQLFSKHGHYESKVTQNAQ 491

  Fly   565 LKAHRTLRDEEG---FLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSS 626
            .:...|:    |   |.:.|:||.|.||...||:||||.|...|...:.:..:|||::|||.|:.
Human   492 RQYDHTM----GLSCFRICHYAGKVTYNVTSFIDKNNDLLFRDLLQAMWKAQHPLLRSLFPEGNP 552

  Fly   627 TSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTIS 691
            .....| ...:.|::||:.:..||:.|.....|:|||||||......||...|...|.:..|.:.
Human   553 KQASLK-RPPTAGAQFKSSVAILMKNLYSKSPNYIRCIKPNEHQQRGQFSSDLVATQARYLGLLE 616

  Fly   692 VLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPA--------RTFCEAMFQSLNLSAKDFKFGI 748
            .:.:...||..|..:......|:      |:|...        |...|.:...|::|:.:..||.
Human   617 NVRVRRAGYAHRQGYGPFLERYR------LLSRSTWPHWNGGDREGVEKVLGELSMSSGELAFGK 675

  Fly   749 TKVFFRPGK---FVEFDRIMRSDPENMLAIVAKV--------------KKWLIRSRWVKSALGAL 796
            ||:|.|..|   ::|..|.:|.  :.:..::.|:              |..::.|.|.:..:...
Human   676 TKIFIRSPKTLFYLEEQRRLRL--QQLATLIQKIYRGWRCRTHYQLMRKSQILISSWFRGNMQKK 738

  Fly   797 CVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREE 861
            |..|::       ..||:.|...||:.|||.:|..::.                         |.
Human   739 CYGKIK-------ASVLLIQAFVRGWKARKNYRKYFRS-------------------------EA 771

  Fly   862 IISGVNDIYRQIDDAIKKIKM---NPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQE 923
            .::..:.||:.:   ::|..:   |...:...:|..:.......      |:|..:|.||...|.
Human   772 ALTLADFIYKSM---VQKFLLGLKNNLPSTNVLDKTWPAAPYKC------LSTANQELQQLFYQW 827

  Fly   924 RLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEMETRRKAA--------------------EA 968
            :.::.::.|          ..:|.|.:..|...:|:...:||:                    :.
Human   828 KCKRFRDQL----------SPKQVEILREKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPKL 882

  Fly   969 QRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPPVIRNG 1033
            |:|:..||   ..:.:.|.::|..:.:.|...::....:.|.:   |.:....|.:     |..|
Human   883 QKLKGGEE---GPVLMAEAVKKVNRGNGKTSSRILLLTKGHVI---LTDTKKSQAK-----IVIG 936

  Fly  1034 VNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQAL--GKQKYDLSKWKYSELRDAINTSC 1096
            :::.:.      :|.:.:...:.|.:|::..:|.::...|  .:...:|....|..:.||.....
Human   937 LDNVAG------VSVTSLKDGLFSLHLSEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQL 995

  Fly  1097 DIELLEACRQEFHRRLK 1113
            .:.:.|    :|..|.|
Human   996 TVTVTE----KFSVRFK 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	263/719 (37%)
		MYSc_Myo6	71..754	CDD:276833	259/709 (37%)
		RILP-like	<968..1015	CDD:304877	8/46 (17%)
		Myosin-VI_CBD	1160..1246	CDD:293129
MYO1A	NP_001242970.1	MYSc	8..694	CDD:214580	266/732 (36%)
		MYSc_Myo1	22..681	CDD:276829	259/709 (37%)
		Actin-binding. /evidence=ECO:0000255	571..593		10/21 (48%)
		IQ	742..764	CDD:197470	9/28 (32%)
		Myosin_TH1	847..1021	CDD:283635	29/183 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920