Protein Alignment jar and MYH9

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_002464.1
• Gene: MYH9 / 4627
• HGNCID: 7579
• Length: 1960
• Species: Homo sapiens
• Alignment Length: 1258
• Identity: 371/1258 - (29%)
• Similarity: 611/1258 - (48%)
• Gaps: 206/1258 - (16%)

  Fly     6 QLVWVRDAAEGYIQGRITEIGAKE--FEVTPTDRKYPKRTCHFDDIHSSCDGPQ--DHDDNCELM 66
            :||||.....|:....:.|...:|  .|:....:|.   ..:.||| ...:.|:  ..:|..||.
Human    30 KLVWVPSDKSGFEPASLKEEVGEEAIVELVENGKKV---KVNKDDI-QKMNPPKFSKVEDMAELT 90

  Fly    67 LLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIA 131
            .||||:.|.|||.|||...||||.....:.:|||:.: .:|:.:.::.|.|:...|:|||::||.
Human    91 CLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNL-PIYSEEIVEMYKGKKRHEMPPHIYAIT 154

  Fly   132 DKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY---SHDS---AGPIETKILDANPVLE 190
            |.|.|.|...:..|||:.:|||||||||:||.:::||.|   ||.|   .|.:|.::|.|||:||
Human   155 DTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQANPILE 219

  Fly   191 AFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGA 255
            |||||||.:|:|||||||||.:::|....:||..|..|||||||...|:.|||.:|:||.||:||
Human   220 AFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGA 284

  Fly   256 PQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLD 320
            .:.|:..|.|...:.||:||         .....|||.|                 |...|....
Human   285 GEHLKTDLLLEPYNKYRFLS---------NGHVTIPGQQ-----------------DKDMFQETM 323

  Fly   321 KALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTE 385
            :|:..:|:.:.|::|:..:::.||.||||.|::    .|...|.|.....:....|.|||::.|:
Human   324 EAMRIMGIPEEEQMGLLRVISGVLQLGNIVFKK----ERNTDQASMPDNTAAQKVSHLLGINVTD 384

  Fly   386 L-RTALVSRV---------MQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLIN 440
            . |..|..|:         .|:|               .:|..|.:|||||.|.|:|..:|..||
Human   385 FTRGILTPRIKVGRDYVQKAQTK---------------EQADFAIEALAKATYERMFRWLVLRIN 434

  Fly   441 QSI---PFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLN 502
            :::   ..|.::| ||:|||||||.|.:|||||.||||.|||||:.||..:...|||.|:|||:.
Human   435 KALDKTKRQGASF-IGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIE 498

  Fly   503 VPEITF-TDNQDIIELIE--AKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSR 564
            ...|.| .|.|..|:|||  |...||..|||||...||.:...|..:|.:....|.:...|:.
Human   499 WNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVEKVMQEQGTHPKFQKPKQ-- 561

  Fly   565 LKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFP------- 622
                  |:|:..|.:.|:||.|.|..::::.||.|.|:.::..|:.:..:..:..|:.
Human   562 ------LKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRIIG 620

  Fly   623 ----SG-SSTSVRG-----KLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEG 677
                :| |.|::.|     |..|.:||..:|.||.:||..|.....||:|||.||.:....:.:.
Human   621 LDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDP 685

  Fly   678 SLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVS--LPARTFCEAMFQSLNLS 740
            .|.|.||:|:|.:..:.:...|:|:||:|.:....|:.:.|..:..  :..:..|..|.::|.|.
Human   686 HLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQACVLMIKALELD 750

  Fly   741 AKDFKFGITKVFFRPG--KFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVK-----SALGAL-- 796
            :..::.|.:|||||.|  ..:|.:|.::. .:.::...|..:.:|.|..:.|     :|:..|
Human   751 SNLYRIGQSKVFFRAGVLAHLEEERDLKI-TDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQR 814

  Fly   797 -CV--IKLRN----RIIYRNKCVLIAQRIARGFLARKQH--RPRYQGIGKINKI-RTNTLKTIEI 851
             |.  :||||    |:..:.|.:|...|.....:|:::.  :.|.:.:...|:: ...||::..:
Human   815 NCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLM 879

  Fly   852 ASGLKMGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQ 916
            |..|::  :|.:....::..:.::      :..|:|.::.:         :.::..||..:::|:
Human   880 AEKLQL--QEQLQAETELCAEAEE------LRARLTAKKQE---------LEEICHDLEARVEEE 927

  Fly   917 Q------QAEE---QERLRKIQEALEAERAAK----------EAEEQRQREE---IENKRLKAEM 959
            :      |||:   |:.:::::|.||.|.:|:          ||:.::..||   :|::..|...
Human   928 EERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAK 992

  Fly   960 ETR----RKAAEAQRLRQEEEDRRAALALQEQ-------LEKEAKDDAKYRQQLEQERRD----- 1008
            |.:    |.|.....|.:|||..::...|:.:       ||:..:.:.|.||:||:.||.
Human   993 EKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057

  Fly  1009 --------------HELALRLANESNGQVEDSPPVIRNGVNDASP--MGPNKLISFSQVVSNIAS 1057
                          .||.::||.:.    |:....:.....:|:.  |...|:......:|.:.
Human  1058 TDLSDQIAELQAQIAELKMQLAKKE----EELQAALARVEEEAAQKNMALKKIRELESQISELQ- 1117

  Fly  1058 RYLNKSENVRAQQQALGKQKYDLS---KWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWK 1119
               ...|:.||.:....|||.||.   :...:||.|.::::...:.|.:.|::....||.....:
Human  1118 ---EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179

  Fly  1120 AKNRKRTTMDENERAPRSVMEAA 1142
            ||..:....:..::..::|.|.|
Human  1180 AKTHEAQIQEMRQKHSQAVEELA 1202

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/43 (23%)
		MYSc_Myo6	71..754	CDD:276833	258/723 (36%)
		CBD_MYO6-like	765..913	CDD:409646	27/164 (16%)
		ERM_helical	<954..1020	CDD:466641	22/95 (23%)
		MYO6_MIU_linker	1002..1093	CDD:480843	24/114 (21%)
		MyUb_Myo6	1076..1116	CDD:439319	11/42 (26%)
		Myosin-VI_CBD	1160..1246	CDD:465157
MYH9	NP_002464.1	Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547	2..838		295/867 (34%)
		Myosin_N	27..72	CDD:460670	10/44 (23%)
		Motor_domain	95..764	CDD:473979	258/723 (36%)
		Actin-binding	654..676		10/21 (48%)
		Myosin_tail_1	841..1921	CDD:460256	75/387 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1057		7/21 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1118..1137		6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1877..1960