Protein Alignment jar and MYH8

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_002463.2
• Gene: MYH8 / 4626
• HGNCID: 7578
• Length: 1937
• Species: Homo sapiens
• Alignment Length: 1296
• Identity: 369/1296 - (28%)
• Similarity: 586/1296 - (45%)
• Gaps: 287/1296 - (22%)

  Fly     8 VWVRDAAEGYIQGRI-----------TEIGAKEFEVTPT---DRKYPKRTCHFDDIHSSCDGPQD 58
            |:|.:..|.|::..|           ||.||     |.|   |:.:|.....:|.|
Human    40 VFVAEPKESYVKSTIQSKEGGKVTVKTEGGA-----TLTVREDQVFPMNPPKYDKI--------- 90

  Fly    59 HDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGEL 123
             :|...:..|:|...|.|||.||....||||.....:.||||:.: .:|.|:.:..|.|:...|.
Human    91 -EDMAMMTHLHEPGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWL-PVYKPEVVAAYRGKKRQEA 153

  Fly   124 PPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLC-----------YSHDSAGP 177
            |||:|:|:|.|.:.|...:.:|||:::||||||||.:||.:::|..           .|....|.
Human   154 PPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKDESGKMQGT 218

  Fly   178 IETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEE 242
            :|.:|:.|||:|||||||||.||:|||||||||.:|:....::....|..|||||||:..|...|
Human   219 LEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAE 283

  Fly   243 RNYHVFYMLLAGAPQQLRDKLSL-GKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLK 306
            |:||:||.:.:.....|.:.|.: ..|.||.::|                          :|.:.
Human   284 RSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVS--------------------------QGEIT 322

  Fly   307 DPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEE-------IPDDVRGGCQV 364
            .|.|||.:.....|.|:..||.:..||:.||.|..||:|.||:.|::       .||    |.:|
Human   323 VPSIDDQEELMATDSAIDILGFTPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPD----GTEV 383

  Fly   365 SEASEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYS 429
            ::.:....::.|..|      |:.....||........||..:.   ::|   ||..|||||:|.
Human   384 ADKAAYLQSLNSADL------LKALCYPRVKVGNEYVTKGQTVQ---QVY---NAVGALAKAVYE 436

  Fly   430 RLFDRIVGLINQSIPF-QASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQ 493
            ::|..:|..|||.:.. |...::||||||||||.|..||.||.|||:.|||||:|||.::...||
Human   437 KMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQ 501

  Fly   494 ELYKREGLNVPEITFTD-NQDI---IELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANH 554
            |.||:||:   |.||.| ..|:   ||||| |..|||::|:||...||.:.:.|.   :|.:..|
Human   502 EEYKKEGI---EWTFIDFGMDLAACIELIE-KPLGIFSILEEECMFPKATDTSFK---NKLYDQH 559

  Fly   555 YRLGLPRSSRLKAHRTLRD--EEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLL 617
                |.:|:..:..:.::.  |..|.:.|:||.|.||...:::||.|.|:.::.||.|:.....|
Human   560 ----LGKSANFQKPKVVKGKAEAHFSLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTL 620

  Fly   618 QTLFPS-----GSSTSVRGK----LNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDR 673
            .:||.:     ..|::.:|.    .:|.:|.:.|:..|.:||..|.....:|:|||.||......
Human   621 ASLFSTYASAEADSSAKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPG 685

  Fly   674 QFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYK----SVLPPELVSLPARTFCEAMF 734
            ..|..|.|.||:|:|.:..:.:...|:|||:|:.|....||    |.: ||...:.::...|.:.
Human   686 AMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAI-PEGQFIDSKKASEKLL 749

  Fly   735 QSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKV----KKWLIRSRWVKSALGA 795
            .|:::....:|||.|||||:.|.....:. ||.  |.:..|:.:.    :.:|:|..:.|
Human   750 ASIDIDHTQYKFGHTKVFFKAGLLGLLEE-MRD--EKLAQIITRTQAVCRGFLMRVEYQK----- 806

  Fly   796 LCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGRE 860
                     ::.|.:.:...|...|.|:..| |.|..:...||..:    ||:.|....:...:|
Human   807 ---------MLQRREALFCIQYNVRAFMNVK-HWPWMKLFFKIKPL----LKSAETEKEMATMKE 857

  Fly   861 EIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKL-------------------- 905
            |        :::..|.:.|.:..    ::|::.....::...|.|
Human   858 E--------FQKTKDELAKSEAK----RKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQ 910

  Fly   906 ----TVDLNTKLKE-QQQAEEQERL--------RKIQEAL--------EAERAAKEAEEQRQREE 949
                .:.|..|:|| .::|||:|.:        ||:::..        :.|....:.|:::...|
Human   911 LIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 975

  Fly   950 IENKRLKAEM----ETRRKAAEAQRLRQE-----------EEDR-----RAALALQEQ---LEKE 991
            .:.|.|..||    ||..|.::.::..||           |||:     :|...|::|   ||..
Human   976 NKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGS 1040

  Fly   992 AKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPPVIRNGVNDASPMG---PNKLISFSQVVS 1053
            .:.:.|.|..||:.:|..|..|:||.||...:|          ||...:.   ..|....|.::|
Human  1041 LEQEKKLRMDLERAKRKLEGDLKLAQESTMDME----------NDKQQLDEKLEKKEFEISNLIS 1095

  Fly  1054 NIAS------RYLNKSENVRAQQQALG--------------KQKYDLSKWKYSELRDAIN----- 1093
            .|..      :...|.:.::|:.:.||              ||:.|||: :..|:.:.:.
Human  1096 KIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSR-ELEEISERLEEAGGA 1159

  Fly  1094 TSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENERAPRSVMEAAFKQPPLVQPIQE 1154
            ||..:||                     |:||..  |.::..|.:.||..:...:|..:::
Human  1160 TSAQVEL---------------------NKKREA--EFQKLRRDLEEATLQHEAMVAALRK 1197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	14/54 (26%)
		MYSc_Myo6	71..754	CDD:276833	253/721 (35%)
		CBD_MYO6-like	765..913	CDD:409646	27/175 (15%)
		ERM_helical	<954..1020	CDD:466641	26/88 (30%)
		MYO6_MIU_linker	1002..1093	CDD:480843	26/113 (23%)
		MyUb_Myo6	1076..1116	CDD:439319	9/44 (20%)
		Myosin-VI_CBD	1160..1246	CDD:465157
MYH8	NP_002463.2	Myosin_N	35..79	CDD:460670	12/43 (28%)
		MYSc_Myh8	102..769	CDD:276882	253/721 (35%)
		Actin-binding	658..680		9/21 (43%)
		Actin-binding	760..774		9/13 (69%)
		Myosin_tail_1	849..1926	CDD:460256	77/395 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1126..1146		5/20 (25%)