Protein Alignment jar and MYH4

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_060003.2
• Gene: MYH4 / 4622
• HGNCID: 7574
• Length: 1939
• Species: Homo sapiens
• Alignment Length: 1450
• Identity: 401/1450 - (27%)
• Similarity: 635/1450 - (43%)
• Gaps: 309/1450 - (21%)

  Fly     8 VWVRDAAEGYIQ--------GRI---TEIGA----KE---FEVTPTDRKYPKRTCHFDDIHSSCD 54
            |:|.|..|.|::        |::   ||.||    ||   |.:.|     ||    :|.|
Human    38 VFVVDPKESYVKAIVQSREGGKVTAKTEAGATVTVKEDQVFSMNP-----PK----YDKI----- 88

  Fly    55 GPQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRS 119
                 :|...:..|:|...|.|||.||....||||.....:.||||:.: .:|.|:.:..|.|:.
Human    89 -----EDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWL-PVYNPEVVTAYRGKK 147

  Fly   120 LGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLC-------------YS 171
            ..|.|||:|:|:|.|.:.|...:.:|||:::||||||||.:||.:::|..             .|
Human   148 RQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEPAS 212

  Fly   172 HDSAGPIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRIC 236
            ....|.:|.:|:.|||:|||||||||.||:|||||||||.:|:.|..::....|..|||||||:.
Human   213 GKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVT 277

  Fly   237 TQSAEERNYHVFYMLLAGAPQQLRDKLSL-GKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQ 300
            .|...||:||:||.:|:....:|.:.|.: ..|.|:.::|
Human   278 FQLKAERSYHIFYQILSNKKPELIEMLLITTNPYDFAFVS------------------------- 317

  Fly   301 QKGPLKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVS 365
             :|.:..|.|||.:.....|.|:..||.:..||:.||.|..||:|.||:.|::...:.:.....:
Human   318 -QGEITVPSIDDQEELMATDSAVDILGFTADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGT 381

  Fly   366 EASEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSR 430
            |.::::..:|| |...|.  |::....||........||..:.   ::|   ||..|||||||.:
Human   382 EVADKAAYLTS-LNSADL--LKSLCYPRVKVGNEFVTKGQTVQ---QVY---NAVGALAKAIYEK 437

  Fly   431 LFDRIVGLINQSIPF-QASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQE 494
            :|..:|..|||.:.. |...::||||||||||.|..||.||.|||:.|||||:|||.::...|||
Human   438 MFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQE 502

  Fly   495 LYKREGLNVPEITF-TDNQDIIELIEAKSNGIFTLLDEESKLPK---PSYSHFTAEVHKSWANHY 555
            .||:||:....|.| .|....||||| |..|||::|:||...||   .|:.:...|.|...:|::
Human   503 EYKKEGIEWEFIDFGMDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNF 566

  Fly   556 RLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTL 620
            :...|...:.:||        |.:.|:||.|.||...:::||.|.|:.::.||.|:.....|..|
Human   567 QKPKPAKGKPEAH--------FSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSAMKTLAFL 623

  Fly   621 FPSGSSTSVR--------GK---LNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQ 674
            | ||:.|:..        ||   .:|.:|.:.|:..|.:||..|.....:|:|||.||.......
Human   624 F-SGAQTAEAEGGGGKKGGKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGA 687

  Fly   675 FEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYK----SVLPPELVSLPARTFCEAMFQ 735
            .|..|.|.||:|:|.:..:.:...|:|||:|:||....||    |.: ||...:.::...|.:..
Human   688 MEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAI-PEGQFIDSKKASEKLLG 751

  Fly   736 SLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIK 800
            |:.:....:|||.|||||:.|.....:. ||.:         |:.:.:.|::.:  ..|.|..::
Human   752 SIEIDHTQYKFGHTKVFFKAGLLGTLEE-MRDE---------KLAQLITRTQAI--CRGFLMRVE 804

  Fly   801 LRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISG 865
            .| :::.|.:.:...|...|.|:..| |.|..:...||..:    ||:.|        .|:.::.
Human   805 FR-KMMERRESIFCIQYNIRAFMNVK-HWPWMKLYFKIKPL----LKSAE--------TEKEMAN 855

  Fly   866 VNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMN------------------------KLT 906
            :.:.:.:..:.:.|.:..    ::|::.....:|...|                        |..
Human   856 MKEEFEKTKEELAKTEAK----RKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTK 916

  Fly   907 VDLNTKLKE-QQQAEEQERL--------RKIQEAL--------EAERAAKEAEEQRQREEIENKR 954
            :.|..|:|| .::||::|.:        ||:::..        :.|....:.|:::...|.:.|.
Human   917 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 981

  Fly   955 LKAEM----ETRRKAAEAQRLRQE-----------EEDR-----RAALALQEQ---LEKEAKDDA 996
            |..||    ||..|..:.::..||           |||:     :|...|::|   ||...:.:.
Human   982 LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEK 1046

  Fly   997 KYRQQLEQERRDHELALRLANESNGQVEDSPPV--------------IRNGVNDASPMGPNKLIS 1047
            |....||:.:|..|..|:||.||....|:....              ::..:.|...:.    |.
Human  1047 KLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALA----IQ 1107

  Fly  1048 FSQVVSNIASRYLNKSENV---RAQQQALGKQKYDLSKWKYSELRDAIN-----TSCDIELLEAC 1104
            ..:.:..:.:|.....|.:   ||.:....||:.|||: :..|:.:.:.     ||..||:.:..
Human  1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR-ELEEISERLEEAGGATSAQIEMNKKR 1171

  Fly  1105 RQEFHR-----------------RLKVYHAWKA------------------KNRKRTTMDENERA 1134
            ..||.:                 .|:..||...                  |.:....|:.|:.|
Human  1172 EAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLA 1236

  Fly  1135 PRSVMEAAFKQP--------PLVQPIQEIVTAQHRYFRIPFMRANAPDNTKRGLWYAHFDGQWIA 1191
              |.||...|..        .|...:.||.|.:....|:    .|.....|..|   |.:....:
Human  1237 --SNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRL----INELSAQKARL---HTESGEFS 1292

  Fly  1192 RQMELHADKPPILLVAG----TDDMQMCELSLEETGLTR----------KRGAEILEHEFNREWE 1242
            ||:: ..|.....|..|    |..::..:..|||....:          :...::|..::..|.|
Human  1293 RQLD-EKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQE 1356

  Fly  1243 RNGGKAYKNLGAAKPNGPAA 1262
               .||....|.:|.|...|
Human  1357 ---AKAELQRGMSKANSEVA 1373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	17/58 (29%)
		MYSc_Myo6	71..754	CDD:276833	257/716 (36%)
		CBD_MYO6-like	765..913	CDD:409646	26/171 (15%)
		ERM_helical	<954..1020	CDD:466641	25/88 (28%)
		MYO6_MIU_linker	1002..1093	CDD:480843	22/107 (21%)
		MyUb_Myo6	1076..1116	CDD:439319	12/61 (20%)
		Myosin-VI_CBD	1160..1246	CDD:465157	17/99 (17%)
MYH4	NP_060003.2	Myosin_N	33..77	CDD:460670	12/38 (32%)
		MYSc_Myh4	100..770	CDD:276879	257/716 (36%)
		Actin-binding. /evidence=ECO:0000250	659..681		9/21 (43%)
		Actin-binding. /evidence=ECO:0000250	761..775		9/13 (69%)
		Myosin_tail_1	850..1927	CDD:460256	101/545 (19%)