Protein Alignment jar and MYO1F

DIOPT Version :9

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_011526326.1
• Gene: MYO1F / 4542
• HGNCID: 7600
• Length: 1119
• Species: Homo sapiens
• Alignment Length: 1101
• Identity: 317/1101 - (28%)
• Similarity: 484/1101 - (43%)
• Gaps: 251/1101 - (22%)

  Fly    60 DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPD-TIKKYNGRSLGEL 123
            ||...|..:.|.....||:.|:..|.|:||:.::||:|||::::.  |..| .|..|.|.:..|.
Human    20 DDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMP--YFTDREIDLYQGAAQYEN 82

  Fly   124 PPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAG-----PIETKIL 183
            |||::|:.|...|:|.:...:|.:|:|||||||||.:.||::.|:  |..|.|     .::..||
Human    83 PPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYI--SKVSGGGEKVQHVKDIIL 145

  Fly   184 DANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVF 248
            .:||:|||||||||.||||||||||:.|:.:....:..||.||::||||||:..|:..|||:|::
Human   146 QSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNFHIY 210

  Fly   249 YMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDY 313
            |.||.||.|:.|..|.|..||.|.||:                   :|..:|..|      .||.
Human   211 YQLLEGASQEQRQNLGLMTPDYYYYLN-------------------QSDTYQVDG------TDDR 250

  Fly   314 QHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGL 378
            ..|.....|:..:|:..:.:..:..|||.:||||||:|.|      .|......|...|...:.|
Human   251 SDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCE------DGNYARVESVDLLAFPAYL 309

  Fly   379 LGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSI 443
            ||:|...|:..|.||.|.|:.|| :...|.|.|.:.:|:..||||||.:|:||||.:|..||:::
Human   310 LGIDSGRLQEKLTSRKMDSRWGG-RSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAM 373

  Fly   444 PFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITF 508
            ......:.||||||.|||.|..|.|||||||:.|||||:.|.:..||.|||.|.:||:....|.:
Human   374 QKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIQY 438

  Fly   509 TDNQDIIELIEAKSN--GIFTLLD-------------EESKLPKPSYSHFTAEVHKSWANHYRLG 558
            .:|:.:.:|||.|.:  ||.::||             :::.|.|...:..|.|...||:
Human   439 FNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNSWS------ 497

  Fly   559 LPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPS 623
                            .||::.|:||.|.|:...|.|:|.|.|.:.|..|:|..:...|:.|||.
Human   498 ----------------AGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFLRMLFPE 546

  Fly   624 GSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFE----------GS 678
            ......:|:.:  :.|||.|.|..:|:..|.:...::|||||||.....|.:|          |.
Human   547 KLDGDKKGRPS--TAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENRTGDSPPRGD 609

  Fly   679 LALA--QLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPA--------------- 726
            .|..  |.:..|.|...|....|..||:.           |||.:..:||
Human   610 SAYPPHQSQAPGGIPGPEGEHQGAQSRLR-----------LPPPVRQIPAEPSALRYAILTPETW 663

  Fly   727 -------RTFCEAMFQSLNLSAKDFKFGITKVF------------FRPGKFVEFDRI-------- 764
                   |...:.:.:::|:....::.|.||||            .|..||..|.|.
Human   664 PRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRH 728

  Fly   765 --------MRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARG 821
                    ||.:..|:|....:.::..|...:|...||    ::.|..:              |.
Human   729 VAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLG----LEERPEL--------------RQ 775

  Fly   822 FLARKQHRPRYQGIGKINK----IRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKIKM 882
            ||.:::.......:.|.::    |:.:.:.|.:..  ..:|||                  |:|.
Human   776 FLGKRERVDFADSVTKYDRRFKPIKRDLILTPKCV--YVIGRE------------------KVKK 820

  Fly   883 NPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQR 947
            .|...|          :..:.|..||:.. |:....:..|:....:||  :|..:..|:..:.:.
Human   821 GPEKGQ----------VCEVLKKKVDIQA-LRGVSLSTRQDDFFILQE--DAADSFLESVFKTEF 872

  Fly   948 EEIENKRLKAEMETRRKA----AEAQRLRQEEE-------------------------DRRAALA 983
            ..:..||.  |..|||..    ::..:.|.::|                         .|...::
Human   873 VSLLCKRF--EEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVTFSRGFGDLAVLKVGGRTLTVS 935

  Fly   984 LQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPP--VIRNGVNDASPMGP 1042
            :.:.|.|.:|...|...: .:.||..:...|.|        .:||  :.||||..::..||
Human   936 VGDGLPKSSKPTRKGMAK-GKPRRSSQAPTRAA--------PAPPRGMDRNGVPPSARGGP 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	256/760 (34%)
		MYSc_Myo6	71..754	CDD:276833	252/749 (34%)
		RILP-like	<968..1015	CDD:304877	9/71 (13%)
		Myosin-VI_CBD	1160..1246	CDD:293129
MYO1F	XP_011526326.1	MYSc	12..711	CDD:214580	256/761 (34%)
		MYSc_Myo1	31..698	CDD:276829	252/737 (34%)
		Myosin_TH1	738..918	CDD:283635	38/232 (16%)
		SH3_MyoIe_If_like	1066..1118	CDD:212761

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920