Protein Alignment jar and myo6a

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001004111.3
• Gene: myo6a / 445473
• ZFINID: ZDB-GENE-040819-2
• Length: 1288
• Species: Danio rerio
• Alignment Length: 1295
• Identity: 681/1295 - (52%)
• Similarity: 910/1295 - (70%)
• Gaps: 42/1295 - (3%)

  Fly     2 LEDTQLVWVRDAAEGYIQGRITEIGAKEFEVTPTDRKYPKRTCHFDDIHSSCDGPQDH-DDNCEL 65
            ::|.:.||.....:|:..|||.:|.|....:.|.:::........|.:..:.|....| :|||.|
Zfish     1 MDDGKPVWAPHPTDGFQLGRIIDISADSLTIEPLNQRGKNFQAPVDQVFPAEDDVNKHVEDNCSL 65

  Fly    66 MLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAI 130
            |.|||||.|:|::.||.||||||:|||||||||||.||.:||:|:|||:|.|||||.|||||:||
Zfish    66 MYLNEATLLNNVRVRYSKDKIYTFVANILIAVNPYCEIPKLYSPETIKQYQGRSLGTLPPHVYAI 130

  Fly   131 ADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETKILDANPVLEAFGNA 195
            ||||.|||:|.|:||||||||||||||||:||::|:||..|:.:...|:.:|::|||:|||||||
Zfish   131 ADKAYRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTTSYGTGQDIDERIVEANPLLEAFGNA 195

  Fly   196 KTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLR 260
            ||.|||||||||||:|:|::.|..||||::|||||||||||||..||||||:||.|.||||:.:|
Zfish   196 KTVRNNNSSRFGKFVEIHFNEKNAVVGGFVSHYLLEKSRICTQGQEERNYHIFYRLCAGAPEDIR 260

  Fly   261 DKLSLGKPDDYRYL-SGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALG 324
            :|..|..||.:||| .|||:||:...:::|||.::||....:.||||||::||:..|:.:..|:.
Zfish   261 EKFHLSSPDCFRYLCRGCTRYFSTKDSDKLIPQNRKSPELLKAGPLKDPLLDDHADFNRMSVAMK 325

  Fly   325 RLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTELRTA 389
            ::||.|||||.::.:||.|||||||.||| .....|||.:.:...|||...:.|||:|:.:||.:
Zfish   326 KIGLDDTEKLNLFRVVAGVLHLGNIDFEE-AGSTSGGCVLKKTCGQSLQFCAELLGLDEEDLRVS 389

  Fly   390 LVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPFQASNFYIGV 454
            |.||||.:..||.|||||.||||:.:||:|||||||||||||||.:|..|||..||.:|..:|||
Zfish   390 LTSRVMLTTAGGTKGTVIKVPLKVEQASSARDALAKAIYSRLFDHVVTRINQCFPFDSSAHFIGV 454

  Fly   455 LDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDIIELIE 519
            |||||||||..||||||||||||||||:|||:.|||.|||||:||||.|.|:.:.||||.|:|:|
Zfish   455 LDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQREGLGVNEVHYVDNQDCIDLVE 519

  Fly   520 AKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAG 584
            :|..||..:||||::||:||..|||..||....:|:||.:||.|:|:.||.:||:|||::|||||
Zfish   520 SKVVGILDILDEENRLPQPSDQHFTETVHSKHKDHFRLTVPRKSKLQVHRNVRDDEGFIIRHFAG 584

  Fly   585 AVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFP----SGSSTSVRGKLNFISVGSKFKTQ 645
            ||||.|.||:||||||||.||..||.|..:..:..||.    |..:....|||:|||||:|||||
Zfish   585 AVCYETTQFVEKNNDALHMSLACLVSESKDKFIGELFENSNHSKDTKQKAGKLSFISVGNKFKTQ 649

  Fly   646 LGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLY 710
            |..|:|||...|::|:||:|||.||:...|||:..|:||:|||.:|||:||:.|:|||..|.:||
Zfish   650 LNILLEKLHSTGSSFVRCVKPNLKMVGHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRAPFHELY 714

  Fly   711 SMYKSVLPPELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAI 775
            :|||..:|.:|..|..|.||:|:|::|.|:..|:|||:||||||||||.|||:||:|||:::..:
Zfish   715 NMYKQYMPAKLTRLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL 779

  Fly   776 VAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINK 840
            |.:|.||||.|||.|....||.||||:|:::||.:..:..|:..|.:|.|::|:||..|:.|...
Zfish   780 VKRVNKWLICSRWKKVQWCALSVIKLKNKMLYRAQACVQMQKTVRMWLCRRKHKPRIDGLVKAQN 844

  Fly   841 IRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKL 905
            ::....|..|:.||||.|::|:...:.|:...||..|:||| :..:::.::|..:..::....:|
Zfish   845 LKKRMEKLNEVVSGLKEGKQEMSKHMQDLDSSIDAHIRKIK-SIVMSRMDIDHEHQALVTRSQEL 908

  Fly   906 TVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEMETRRKAAEAQR 970
               |:...|::|:.||.|||::|||.:|.||..:|.|||:::.|.|.:|.|||||.:||..|.:|
Zfish   909 ---LSAMQKKKQEEEEMERLKRIQEEMEKERKRREEEEQKRKREEEERRQKAEMELKRKQEEEER 970

  Fly   971 LRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQV--EDSPPVIRNG 1033
            .::|||:|:....::.|||.|.:.:...:..|||||||.|||||:| :|..::  |::||  ..|
Zfish   971 KKREEEERKLQEEMELQLEAEREQETSRQAVLEQERRDRELALRIA-QSEAELIPEETPP--DAG 1032

  Fly  1034 VNDASPMGPNKLISFS-QVVSNIASRYLNKSENVRAQQQALGKQKYDLSKWKYSELRDAINTSCD 1097
            :...:|  |.||.|.: :.::...|..|.:...|.|.......:||:||||||:|||||||||||
Zfish  1033 LRSVAP--PQKLKSLTMEEMAKEMSDLLARGPQVSANNAQADVKKYELSKWKYAELRDAINTSCD 1095

  Fly  1098 IELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENERAPRSVME-------AAF--KQPPLVQ--- 1150
            ||||.|||:|||||||||||||:||:||...:| :|||:::.:       .||  :|.|:|.
Zfish  1096 IELLAACREEFHRRLKVYHAWKSKNKKRNVQEE-QRAPKAITDYVGIIGSQAFIAQQNPVVPAAV 1159

  Fly  1151 PIQE--IVTAQHRYFRIPFMRA----NAPDNTKRGLWYAHFDGQWIARQMELHADKPPILLVAGT 1209
            |.|.  ::..|.|:|||||:|.    ..|.:.|:|.|||||||.|||||||||.||.|||||||.
Zfish  1160 PRQHEIVMNRQQRFFRIPFIRPGDQYKDPQSKKKGWWYAHFDGPWIARQMELHPDKHPILLVAGK 1224

  Fly  1210 DDMQMCELSLEETGLTRKRGAEILEHEFNREWERNGGKAY-KNL---GAAKPNGPAAAMQ 1265
            |||:||||||||||||||||||||..:|...|||.||..| :|.   ..|:|....|.:|
Zfish  1225 DDMEMCELSLEETGLTRKRGAEILPRQFEEIWERCGGIQYLRNAIESRQARPTYATAMLQ 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/41 (24%)
		MYSc_Myo6	71..754	CDD:276833	411/687 (60%)
		CBD_MYO6-like	765..913	CDD:409646	50/147 (34%)
		ERM_helical	<954..1020	CDD:466641	31/65 (48%)
		MYO6_MIU_linker	1002..1093	CDD:480843	40/93 (43%)
		MyUb_Myo6	1076..1116	CDD:439319	34/39 (87%)
		Myosin-VI_CBD	1160..1246	CDD:465157	62/89 (70%)
myo6a	NP_001004111.3	None