Protein Alignment jar and myo6b

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001004110.1
• Gene: myo6b / 445472
• ZFINID: ZDB-GENE-030318-3
• Length: 1267
• Species: Danio rerio
• Alignment Length: 1289
• Identity: 675/1289 - (52%)
• Similarity: 889/1289 - (68%)
• Gaps: 54/1289 - (4%)

  Fly     2 LEDTQLVWVRDAAEGYIQGRITEIGAKEFEVTPTDRKYPKRTCHFDDIHSSCDGPQDH-DDNCEL 65
            ::|.:|||.....:|:..|.|.:|||....:.|..::..........:..:.|....| :|||.|
Zfish     1 MDDGKLVWAPHPTDGFQLGMIVDIGADALTIEPLHQRGKTFLAPISQVFPAEDDVNKHVEDNCSL 65

  Fly    66 MLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAI 130
            |.|||||.|:|::.||.||.|||:|||||||||||.:|.:||:|::||.|.|||||.|||||:||
Zfish    66 MYLNEATLLNNIRIRYSKDMIYTFVANILIAVNPYFDIPKLYSPESIKSYQGRSLGTLPPHVYAI 130

  Fly   131 ADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETKILDANPVLEAFGNA 195
            ||||.|||||.|:||||||||||||||||:||::|:||..|:.:...|:.:|::|||:|||||||
Zfish   131 ADKAYRDMRVLKMSQSIIVSGESGAGKTENTKFVLRYLTTSYGTGQDIDERIVEANPLLEAFGNA 195

  Fly   196 KTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLR 260
            ||.|||||||||||:|:|::.|..||||::|||||||||||.||.||||||:||.|.|||.:.:|
Zfish   196 KTVRNNNSSRFGKFVEIHFNEKNAVVGGFVSHYLLEKSRICMQSQEERNYHIFYRLCAGASEDIR 260

  Fly   261 DKLSLGKPDDYRYLS-GCTQYFANAKTEQLIPGSQKS---KNHQQKGPLKDPIIDDYQHFHNLDK 321
            :.|.|..||.:|||: |||:||||..:::.|..: ||   ..|.:.|.||||::||...|:.:..
Zfish   261 NMLHLNSPDSFRYLNRGCTRYFANKDSDKQIMQNXKSPEDHKHGKVGALKDPLLDDLGDFNRMVV 325

  Fly   322 ALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTEL 386
            |:.::||.|||||.::.:||.|||||||.||| .....|||.:...|.|:|...:.|||:||.:|
Zfish   326 AMKKIGLDDTEKLNLFRVVAGVLHLGNIDFEE-TGSTSGGCILKNQSSQTLEYCADLLGLDQDDL 389

  Fly   387 RTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPFQASNFY 451
            |.:|.:|||.:..||.|||||.||||:.:|:|||||||||:||||||.:|..:||..||..|:.:
Zfish   390 RVSLTTRVMLTTAGGAKGTVIKVPLKVEQANNARDALAKAVYSRLFDHVVKRVNQCFPFDTSSNF 454

  Fly   452 IGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDIIE 516
            |||.||||||||..||||||||||||||||:|||:.|||.|||||:||||.|.|:.:.||||.|:
Zfish   455 IGVPDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQREGLGVNEVHYVDNQDCID 519

  Fly   517 LIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDEEGFLVRH 581
            |:|||..|:..:||||::||:||..||...||....:|:||.:||.|:|..||.|||:|||::||
Zfish   520 LVEAKLVGVLDILDEENRLPQPSDQHFAEAVHSKHKDHFRLTVPRKSKLTIHRNLRDDEGFIIRH 584

  Fly   582 FAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGS----STSVRGKLNFISVGSKF 642
            |||||||.|.||:||||||||.|||.||.|..:..::.||.:.|    |....|||:|||||:||
Zfish   585 FAGAVCYETTQFVEKNNDALHMSLESLVCESKDKFVRDLFENNSNSKDSKQKAGKLSFISVGNKF 649

  Fly   643 KTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFA 707
            ||||..|:|||...|::||||:|||.||:..||||:..|:||:|||.:|||:||:.|:|||..|.
Zfish   650 KTQLNLLLEKLRSTGSSFIRCVKPNLKMVSHQFEGAQILSQLQCSGMVSVLDLMQGGFPSRAPFH 714

  Fly   708 DLYSMYKSVLPPELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENM 772
            :||:|||..:|.:|..|..|.||:|:|::|.|:..|:|||:|:||||||||.|||:||:|||:::
Zfish   715 ELYNMYKQYMPNKLTRLDPRLFCKALFKALGLNENDYKFGLTRVFFRPGKFAEFDQIMKSDPDHL 779

  Fly   773 LAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGK 837
            ..:|.:|.|||:.|||.|.....|.||||||::.||....:..|:..|.:|.|::|:||..|:.|
Zfish   780 AELVKRVNKWLVCSRWKKVQWCTLSVIKLRNKMSYRASACIRIQKTVRMWLCRRRHKPRVDGLVK 844

  Fly   838 INKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANM 902
            :..:|....:..|..:|||.|:.|:...:.::....|..:.|||... ::::|::..|..::...
Zfish   845 VKNLRKRMERFNEAVNGLKEGKAEMSKQIEELAASTDALMAKIKTTV-MSRKEIEQEYEGLVKRS 908

  Fly   903 NKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEMETRRKAAE 967
            .:|   |::..|::|:.||.|||:.|||.:|.||...|.|||.:::|.|::|:|:|||.:||..|
Zfish   909 EQL---LSSMQKKKQEQEETERLKHIQEZMEKERKRHEEEEQLRKQEEEDRRMKSEMEQKRKQEE 970

  Fly   968 AQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVEDS---PPV 1029
            .:|.::|||:|.....|:.||..:.:::.:.:..|||||||.|||:|:|......::|.   .|:
Zfish   971 EERKKREEEERVLQAELEMQLALDREEETQRQTILEQERRDRELAMRIAQNEAELIQDEAQMDPI 1035

  Fly  1030 IR----NGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQKYDLSKWKYSELRD 1090
            :|    .||...:.||                      ..|:|.:.|.|.:|||||||||:||||
Zfish  1036 LRRDATTGVWFFTEMG----------------------AQVQANKVAAGVKKYDLSKWKYAELRD 1078

  Fly  1091 AINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENERAPRSVMEAAFKQ--PPLVQPIQ 1153
            |||||||||||.|||:|||||||||||||:||:||.| |...|||:||.:.|.:.  ||:....|
Zfish  1079 AINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNT-DTEMRAPKSVTDYAQQNPAPPVPARQQ 1142

  Fly  1154 EI-VTAQHRYFRIPFMRA----NAPDNTKRGLWYAHFDGQWIARQMELHADKPPILLVAGTDDMQ 1213
            || :..|.|||||||:|.    ..|.|.|:|.|||||||.|||||||||.||.|||||||.|||:
Zfish  1143 EIAMNRQQRYFRIPFIRPADQYKDPQNKKKGWWYAHFDGPWIARQMELHPDKQPILLVAGKDDME 1207

  Fly  1214 MCELSLEETGLTRKRGAEILEHEFNREWERNGGKAY-KNLGAAKPNGP--AAAM 1264
            ||||||||||||||||||||..:|...|||.||..| ||...:|...|  |.||
Zfish  1208 MCELSLEETGLTRKRGAEILPRQFEEIWERCGGIQYLKNAIESKQARPTYATAM 1261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/41 (24%)
		MYSc_Myo6	71..754	CDD:276833	408/690 (59%)
		CBD_MYO6-like	765..913	CDD:409646	46/147 (31%)
		ERM_helical	<954..1020	CDD:466641	28/65 (43%)
		MYO6_MIU_linker	1002..1093	CDD:480843	37/97 (38%)
		MyUb_Myo6	1076..1116	CDD:439319	35/39 (90%)
		Myosin-VI_CBD	1160..1246	CDD:465157	64/89 (72%)
myo6b	NP_001004110.1	Myosin_N	2..>32	CDD:460670	10/29 (34%)
		MYSc_Myo6	71..761	CDD:276833	408/690 (59%)
		CBD_MYO6-like	772..919	CDD:409646	47/150 (31%)
		DUF4670	<872..1032	CDD:464815	56/163 (34%)
		MYO6_MIU_linker	1001..1081	CDD:412090	37/101 (37%)
		MyUb_Myo6	1064..1104	CDD:439319	35/39 (90%)
		Myosin-VI_CBD	1150..1240	CDD:465157	64/89 (72%)