Protein Alignment jar and MYO1B

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_047300366.1
• Gene: MYO1B / 4430
• HGNCID: 7596
• Length: 1156
• Species: Homo sapiens
• Alignment Length: 1183
• Identity: 350/1183 - (29%)
• Similarity: 563/1183 - (47%)
• Gaps: 182/1183 - (15%)

  Fly    68 LNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIAD 132
            |||.||::|||.|:...:||||:.:::|:|||||.: .:|:|:.:::|..|:..||.||:||::|
Human    46 LNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSL-PIYSPEKVEEYRNRNFYELSPHIFALSD 109

  Fly   133 KAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKY---LCYSHDSAGPIETKILDANPVLEAFGN 194
            :|.|.:|.....|.|:::|||||||||::|.::.|   :|........::.::|.:|||||||||
Human   110 EAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGN 174

  Fly   195 AKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQL 259
            |||.||:|||||||::::.:|.|...:||.||:|||||||:..|...|||:||||.||:||.::|
Human   175 AKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEEL 239

  Fly   260 RDKLSLGKP-DDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKAL 323
            .:||.|.:. ..|.|||     ..:||...                     :||..:|..:..|:
Human   240 LNKLKLERDFSRYNYLS-----LDSAKVNG---------------------VDDAANFRTVRNAM 278

  Fly   324 GRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQS-LTITSGLLGVDQTELR 387
            ..:|..|.|...:.::|||||.||||.|:  |:....|...|:..::: |.....|.|:||:.|.
Human   279 QIVGFMDHEAESVLAVVAAVLKLGNIEFK--PESRVNGLDESKIKDKNELKEICELTGIDQSVLE 341

  Fly   388 TALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPFQAS--NF 450
            .|...|.:::     |...:...|.:.:|..|||||||.:|||||..:|..||:||..|..  ..
Human   342 RAFSFRTVEA-----KQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKK 401

  Fly   451 YIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDII 515
            .:|||||.|||.|..||||||.|||||||||:.|.:..||.|||.|.||.:....|.:.:|..|.
Human   402 VMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIIC 466

  Fly   516 ELIEAKSNGIFTLLDEESKLP-KPSYSHFTAEVHKSWANHYRLGLPRSSRL-KAHRTLRD----E 574
            :|||..:|||..:||||...| ..:...|..::::..|.|...    .||: |..|.|.|    .
Human   467 DLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHF----ESRMSKCSRFLNDTSLPH 527

  Fly   575 EGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVRGKLNF---I 636
            ..|.::|:||.|.|..|.|::||||.|:..|...:.:..:.|:::|||.|:.    .|:|.   .
Human   528 SCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNP----AKINLKRPP 588

  Fly   637 SVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYP 701
            :.||:||..:..||:.|:....|:|||||||.|.....|..:|...|::..|.:..:.:...||.
Human   589 TAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYA 653

  Fly   702 SRVLFADLYSMYKSVLP---PELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFR-PGKFVEFD 762
            .|..:......||.:..   |.... |||:..|.:|..|.:..:::.||.:|:|.| |....:.:
Human   654 FRQAYEPCLERYKMLCKQTWPHWKG-PARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLE 717

  Fly   763 RIMRSDPENMLAIVAKV-KKWLIRSRWVKSALGALCVIKLRNRIIYRNK------CVLIAQRIAR 820
            .:.:...|::..::.|: :.|..|:.::......:.:.....|...:.:      ..|:.|...|
Human   718 DLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIR 782

  Fly   821 GFLARK-----QHRPR-----------YQGIGKINKIR------------------------TNT 845
            |:.|||     :|:.|           :.|.....::|                        ...
Human   783 GWKARKILRELKHQKRCKEAVTTIAAYWHGTQARRELRRLKEEARNKHAIAVIWAYWLGSKARRE 847

  Fly   846 LKTIEIAS--------------GLKMGREEIISGVNDIYRQI--DDAIKKIKMNPRITQREMDSM 894
            ||.::..:              |||:.||         ||:.  .:|.|||.   ..|.:.:...
Human   848 LKRLKEEARRKHAVAVIWAYWLGLKVRRE---------YRKFFRANAGKKIY---EFTLQRIVQK 900

  Fly   895 YTVVMAN-MNKLT-VDLN-------------TKLKE----------QQQAEEQERLRKIQEALEA 934
            |.:.|.| |..|: :|.|             .:||.          :.|..:|::| ..:|.|||
Human   901 YFLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKL-IYEEKLEA 964

  Fly   935 ERAAKEAEEQRQREEIENKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYR 999
            ....|: ::......:......|.:|. .|..:.::|:...|::   :.:.|.:.|..:.:.|..
Human   965 SELFKD-KKALYPSSVGQPFQGAYLEI-NKNPKYKKLKDAIEEK---IIIAEVVNKINRANGKST 1024

  Fly  1000 QQLEQERRDHELALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSE 1064
            .::.....::   |.||::.:||::...|::  .|...|....|.  .|..|.....|...:|.:
Human  1025 SRIFLLTNNN---LLLADQKSGQIKSEVPLV--DVTKVSMSSQND--GFFAVHLKEGSEAASKGD 1082

  Fly  1065 NVRAQQQALGKQKYDLSKWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMD 1129
            .:.:....: :....|.:...|:.:..:|.....|.|...||:     ||...:...|:|..::.
Human  1083 FLFSSDHLI-EMATKLYRTTLSQTKQKLNIEISDEFLVQFRQD-----KVCVKFIQGNQKNGSVP 1141

  Fly  1130 ENERAPRSVMEAA 1142
            ..:|....::|.|
Human  1142 TCKRKNNRLLEVA 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	263/701 (38%)
		CBD_MYO6-like	765..913	CDD:409646	37/225 (16%)
		ERM_helical	<954..1020	CDD:466641	11/65 (17%)
		MYO6_MIU_linker	1002..1093	CDD:480843	15/90 (17%)
		MyUb_Myo6	1076..1116	CDD:439319	9/39 (23%)
		Myosin-VI_CBD	1160..1246	CDD:465157
MYO1B	XP_047300366.1	MYSc_Myo1	49..708	CDD:276829	263/701 (38%)
		IQ	769..791	CDD:197470	7/21 (33%)
		Myosin_TH1	961..1138	CDD:461801	36/194 (19%)