Protein Alignment jar and Myo1a

DIOPT Version :9

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001074688.1
• Gene: Myo1a / 432516
• MGIID: 107732
• Length: 1043
• Species: Mus musculus
• Alignment Length: 1127
• Identity: 335/1127 - (29%)
• Similarity: 538/1127 - (47%)
• Gaps: 190/1127 - (16%)

  Fly    54 DGPQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGR 118
            :||...:|...|..|:|.:.:.||:.||...:||||:.|::|::|||.:: .:|.|:.|.||...
Mouse     5 EGPVGVEDLILLEPLDEESLIKNLQLRYENKEIYTYIGNVVISMNPYEQL-PIYGPEFIAKYRDY 68

  Fly   119 SLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKY---LCYSHDSAGPIET 180
            :..||.||::|:|:.|.:.::.....|.|:::|||||||||::|.::.|   :|...:....::.
Mouse    69 TFYELKPHIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAVCGKGEQVNSVKE 133

  Fly   181 KILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNY 245
            ::|.:||||||||||||.||||||||||::::.:|.|...:||.|::|||||||:..|...|||:
Mouse   134 QLLQSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGERNF 198

  Fly   246 HVFYMLLAGAPQQLRDKLSLGKPDD-YRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPI 309
            |:||.|||||..||...|.|.:... |.||:|                 :.||.:.
Mouse   199 HIFYQLLAGADAQLLKALKLEEDTSVYGYLNG-----------------EVSKVNG--------- 237

  Fly   310 IDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEE------IP-DDVRGGCQVSEA 367
            :||..:|..:..|:..:|.|:.|...:..:.|.||.|||:...:      || ..:..|..:.|.
Mouse   238 MDDASNFRAVQHAMSVIGFSEEEIRQVLEVTALVLKLGNVKLTDEFQANGIPASGICDGKGIQEI 302

  Fly   368 SEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLF 432
            .|        ::|::.|||..||.||.|::.    |..|:.| |.:.:|..|||||||.||||||
Mouse   303 GE--------MMGLNSTELERALCSRTMETG----KEKVVTV-LNVTQAQYARDALAKNIYSRLF 354

  Fly   433 DRIVGLINQSIPFQA--SNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQEL 495
            |.||..||:||....  ....:|||||.|||....||||||.||||||:||:.|.:..||.|||.
Mouse   355 DWIVKRINESIKVGTGEKKKVMGVLDIYGFEILEDNSFEQFVINYCNERLQQVFIELTLKEEQEE 419

  Fly   496 YKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLP-KPSYSHFTAEVHKSWA--NHYRL 557
            |||||:...::.:.||..|..|||....||..:||||...| ..|.|.|.|::::.::  :||..
Mouse   420 YKREGIPWTKVEYFDNGIICNLIEHSQRGILAMLDEECLRPGVVSDSTFLAKLNQLFSKHSHYES 484

  Fly   558 GLPRSSRLKAHRTLRDEEG---FLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQT 619
            .:.::::.:..||:    |   |.:.|:||.|.||...||:||||.|...|...:.:..:|||::
Mouse   485 KVSQNAQRQYDRTM----GLSCFRISHYAGKVTYNVTGFIDKNNDLLFRDLSQTMWKAQHPLLKS 545

  Fly   620 LFPSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQL 684
            |||.|:......| ...:.|::||..:..||:.|.....|:|||||||.:....:|...:.:.|.
Mouse   546 LFPEGNPKEASLK-RPPTAGTQFKNSVAVLMKNLYSKNPNYIRCIKPNDQQQKGRFTSEMVMVQA 609

  Fly   685 KCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPA--------RTFCEAMFQSLNLSA 741
            :..|.:..:.:...||..|..:......|:      |:|...        |...|.:..||.||:
Mouse   610 RYLGLLENVRVRRAGYAFRQGYKPFLERYR------LLSRSTWPRWNGDDREGVEKVLGSLTLSS 668

  Fly   742 KDFKFGITKVFFRPGK---FVEFDRIMRSDPENMLAIVAKV-KKWLIRSRWVKSALGALCVI--- 799
            ::..:|.||:|.|..|   ::|..|.:|.  :.:..::.|| :.|..|:.:.:.....:.:.
Mouse   669 EELAYGKTKIFIRSPKTLFYLEEQRRLRL--QQLATLIQKVYRGWRCRTHYQQMRKSQILISAWF 731

  Fly   800 ----------KLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASG 854
                      |:|:       .||:.|...||:.|||.:|..:         |:....|:
Mouse   732 RGNKQKKHYGKIRS-------SVLLIQAFVRGWRARKNYRKYF---------RSGAALTL----- 775

  Fly   855 LKMGREEIISGVNDIYRQI-DDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQ 918
                       .|.||:.: ...:..:|.|...| :.:|:.:.......      .||..:|.|:
Mouse   776 -----------ANFIYQSMAQKFLLNLKKNLPST-KVLDNTWPAAPYRC------FNTANQELQR 822

  Fly   919 AEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEMETRRKAA----------------- 966
            ...|.:.:|.::.|          ..:|.:.:..|...:|:...:||:
Mouse   823 LFYQWKCKKFRDQL----------SPKQVQTLREKLCASELFKGKKASYPQSVPIPFRGDYIGLQ 877

  Fly   967 ---EAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPP 1028
               :.|||:..||   ..:.:.:.::|..:.:.|...::....:.| :.|..|.:|..|:
Mouse   878 GNPKLQRLKGREE---GPVLVADTVKKVNRGNGKTSARILLLTKGH-VILTDAKKSQAQI----- 933

  Fly  1029 VIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQAL--GKQKYDLSKWKYSELRDA 1091
            ||  |:.|.:.      :|.|.:...:.|.:|::..:..::...|  .....:|....|..:.||
Mouse   934 VI--GLEDVAG------VSVSSLQDGLFSLHLSEMSSAVSKGDILLVSDHVVELLTKMYQAVLDA 990

  Fly  1092 INTSCDIELLEACRQEFHRRLK 1113
            ......:.:.|    :|..|.|
Mouse   991 TQRQLSVTVTE----KFSVRFK 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	263/721 (36%)
		MYSc_Myo6	71..754	CDD:276833	259/709 (37%)
		RILP-like	<968..1015	CDD:304877	9/46 (20%)
		Myosin-VI_CBD	1160..1246	CDD:293129
Myo1a	NP_001074688.1	MYSc_Myo1	22..681	CDD:276829	259/709 (37%)
		Actin-binding. /evidence=ECO:0000255	571..593		10/21 (48%)
		IQ	742..764	CDD:197470	10/28 (36%)
		Myosin_TH1	847..1042	CDD:368706	33/183 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920