DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and Mhcl

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster

Alignment Length:	1345	Identity:	288/1345 - (21%)
Similarity:	512/1345 - (38%)	Gaps:	314/1345 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELP 124
            :|.|||..||||:.|..|:.||..:.|:|.....|:.|||...: .||:...:..:.|....::|
  Fly   564 EDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPL-SLYSEKVVSMFRGCKTEDMP 627

  Fly   125 PHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIET-----KILD 184
            |||:::|..|.|.:...:..||:|..|.||:||:.|.|:.|.||..   :||....     |:..
  Fly   628 PHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLAL---AAGAYNNFINAEKVNA 689

  Fly   185 ANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFY 249
            ...:||||||.||..|:|::|..:.:.:.:|...|:....:...|.|:.|...:...|.::|:..
  Fly   690 LCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMT 754

  Fly   250 MLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQ 314
            .|||||...|:.:|.|                .|..:|...|....|:..:.:....:..:...|
  Fly   755 RLLAGAAGLLQKELHL----------------ENITSEDSHPFISLSQKLEDRHRAANDFMRTVQ 803

  Fly   315 HFH--NLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSG 377
            .|.  |:|....|         ||:|::||:.|||.....::........|.  |:..:....||
  Fly   804 AFETLNIDAKAVR---------GIWSILAAIYHLGIAGVTKLGTGSTARTQF--ANPTAARKASG 857

  Fly   378 LLGVDQTELRTALVSRVM-QSKGGGFKGTVIMVPLKIYEASNAR-------DALAKAIYSRLFDR 434
            ||||:..:|.:|...... .:..||      :.|.|...:....       :||...:||.....
  Fly   858 LLGVNLEDLSSAAFGLTQPNAPNGG------LSPSKSPTSDTGHEWAWECLEALVIGLYSEALAA 916

  Fly   435 IVGLINQSIPFQASNF-YIGVLDIAGFEY---------FTVNSFEQFCINYCNEKLQKFFNDNIL 489
            :|.|||:.|...:... .|.::|..||:.         .|:.....   ||..|:||..|:...|
  Fly   917 VVALINRQICTSSHTIASIMLIDTPGFQNPASCGQQVGATLADLRH---NYLQERLQMLFHHTTL 978

  Fly   490 KNEQELYKREGLNV-----------PEITFTDN--QDII------ELIEAKSNGIFTLLDEESKL 535
            ...::.|.:|.:.:           |.|:..|.  |:.:      :|.|....|:..|||||:..
  Fly   979 VAPRDRYAQELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIY 1043

  Fly   536 PKPS--------YSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDEEG---FLVRHFAGA--VC 587
            |..:        :||:....|                   |..||...|   |::.|..|.  |.
  Fly  1044 PNSNDDTFLERLFSHYGDREH-------------------HSLLRKCAGPRQFVLHHLQGTNPVL 1089

  Fly   588 YNTEQFIEKNNDALHASLE---GLVQECDNPLLQTLFPS------------GSSTSVRG------ 631
            |..:.::..:.:  |..:.   .|:|:.....:..|:..            ||...:.|
  Fly  1090 YAVDGWVRHSRE--HPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRR 1152

  Fly   632 ----KLNFISVGSK-------FKTQLGELMEKLEQNGTNFIRC--IKPNS-KMIDRQFEGS---- 678
                :.:|.:.|.|       .|..:..:::.|.:.||:|:.|  ::.|: |.......||
  Fly  1153 VSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSA 1217

  Fly   679 --------------LALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPARTF 729
                          |..:||:.|..:....|...|:|..|...:....: .:|..:|.| .....
  Fly  1218 AGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRF-GLLAGDLAS-NKDVS 1280

  Fly   730 CEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDR---IMRSDPENMLAIVAKVKKWLIRSRWVKS 791
            .|.:.....|....::.|.:::.||.|...|.:.   ::.||  .::.:.|..:.:|.|.:..:.
  Fly  1281 VEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSD--RIIQLQAFCRGYLARKKMSQR 1343

  Fly   792 ALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLK 856
            .:..|.|           :|:   ||..:.|||.:.. |.::.:.::..: .|..:|.|   .||
  Fly  1344 RVQELAV-----------RCI---QRNVKAFLAVRDW-PWWRLLVRVTPL-LNVHRTEE---QLK 1389

  Fly   857 MGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTK------LKE 915
            ...||::        .:...::||:.:    :.|:.:....:.|.:::|||||..:      ..|
  Fly  1390 TANEELL--------MLRAKLEKIECD----RSEVKAENQKLEAKLSELTVDLAEERSTAHIATE 1442

  Fly   916 QQQAEEQERLRKIQEALEAERAAKEAEEQRQR------------------EEIENK--------R 954
            :.:||..|||:..:|..:.....|..:|..::                  |:.||:        :
  Fly  1443 RLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYK 1507

  Fly   955 LKAEMETRRKAAEAQRLR-QEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANE 1018
            ||.|...|......:||. |.|.|....:||::.||.:..|  .|.:.:||            .:
  Fly  1508 LKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSD--AYEEVVEQ------------RQ 1558

  Fly  1019 SNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQKYDLSKW 1083
            ..||.:.....:.|.:||.                    |.|.:.:|.|.......::|:|.
  Fly  1559 VVGQWKRKAQKMTNEMNDL--------------------RMLLEEQNARNNLLEKKQRKFDA--- 1600

  Fly  1084 KYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENERAPRSVMEAAFKQPPL 1148
            :...|:||:...      ...::.:.|...|..|      ::.|:::.....|  ::..||:..|
  Fly  1601 ECQSLQDAVRQE------RQAKERYGREKDVLQA------EKFTLEQTLADTR--LDLEFKEEKL 1651

  Fly  1149 V---QPIQEIVTAQHRYFRIPFMRANAPDNTKRGLWYAHFDGQWIARQMELHADKPPILLVAGTD 1210
            .   :.::|:............:|.:..:..:|            |::.|...|:     :||..
  Fly  1652 ASLQRELEEMTFGGGTEEEFAQLRRSKNETERR------------AKEQEEELDE-----MAGQI 1699

  Fly  1211 D-MQMCELSLEETGLTRKRGAEILEHEFNREWERNGGKAYKNLGA 1254
            . ::..:|.||.|..|.::.|.....:.:.|.|...|..||.:.|
  Fly  1700 QLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKA 1744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	183/803 (23%)
		MYSc_Myo6	71..754	CDD:276833	176/792 (22%)
		RILP-like	<968..1015	CDD:304877	13/47 (28%)
		Myosin-VI_CBD	1160..1246	CDD:293129	15/86 (17%)
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580	187/815 (23%)
		MYSc_Myo18	575..1305	CDD:276837	176/792 (22%)
		GBP_C	<1540..1750	CDD:303769	48/273 (18%)
		COG1340	1565..1833	CDD:224259	40/234 (17%)
		coiled coil	1723..1734	CDD:293879	2/10 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466247
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930