Protein Alignment jar and didum

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Alignment Length: 1468
• Identity: 395/1468 - (26%)
• Similarity: 639/1468 - (43%)
• Gaps: 387/1468 - (26%)

  Fly    60 DDNCELMLLNEATFLDNLKTRYYKDK-IYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGEL 123
            :|...|..|:|...|.||:.|:.:.: ||||...||:|:|||.|: .||.|..|:.|.|.::|:|
  Fly    73 NDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEM-PLYGPSIIRAYRGHAMGDL 136

  Fly   124 PPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY--SHDSAGPIETKILDAN 186
            .||:||:|::|...:.....:.|||||||||||||.|.||.::|...  ..:|...:|.|:|.::
  Fly   137 EPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASS 201

  Fly   187 PVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVV---GGYISHYLLEKSRICTQSAEERNYHVF 248
            |::|||||||||||:||||||||.::.:..:..|:   |..:..|||||||:..|:..|||||:|
  Fly   202 PIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIF 266

  Fly   249 YMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDY 313
            |.|.|...:.  .:|.|...|.:::|:              :.|:.:.:.           :.|.
  Fly   267 YQLCAARSKY--PELVLDHQDKFQFLN--------------MGGAPEIER-----------VSDA 304

  Fly   314 QHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQS------- 371
            :.|:...:|:..||.|..:...|..::|.:||||||...:         :.:|.||:.
  Fly   305 EQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSK---------KFNEGSEEEDSDSCDI 360

  Fly   372 ------LTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSR 430
                  |.||:.||.|...:||..|:.|.::|     ....:::|..|..|..|||||||.||::
  Fly   361 FHNDIHLQITADLLRVSADDLRRWLLMRKIES-----VNEYVLIPNSIEAAQAARDALAKHIYAK 420

  Fly   431 LFDRIVGLINQSI---PFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNE 492
            ||..|||::|:|:   ..|.|  :||||||.|||.|.|||||||||||.|||||:.||.::.|.|
  Fly   421 LFQYIVGVLNKSLNNGSKQCS--FIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLE 483

  Fly   493 QELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRL 557
            ||.|.:||:....|.|.|||..|:|||::. |:..|||||.::||.|        .:|||... :
  Fly   484 QEEYLKEGITWTMIDFYDNQPCIDLIESRL-GVLDLLDEECRMPKGS--------DESWAGKL-I 538

  Fly   558 G----LPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPL-- 616
            |    .|...:.:...|     .|.::||:..|.|:...|:|||.|.:...|..::.|.:..|
  Fly   539 GKCNKFPHFEKPRFGTT-----SFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAK 598

  Fly   617 -------LQTLFPSGSSTSVRGKLNFIS-----------------------VGSKFKTQLGELME 651
                   :.||....:.:|..|....||                       |||:|:..|..|:.
  Fly   599 QVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLIS 663

  Fly   652 KLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYS----- 711
            .|.....:::||||||...:..::|.:..:.||:..|.:..:.:...|:|||.|:.|.|.
  Fly   664 TLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLL 728

  Fly   712 MYKSVLPPELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIV 776
            :|:|.|....:.|..|.......|    ....::||.|::|||.|:....:::..:..:..:.||
  Fly   729 VYRSKLDKNDMKLSCRNIVMKWIQ----DEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIV 789

  Fly   777 -AKVKKWLIRSRWV-----------------------------------KSALGALC---VIKLR 802
             :.|::::.|.:::                                   |.|.|.||   .::||
  Fly   790 QSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLR 854

  Fly   803 NRI----------IYRNK---------CVLIAQRIARGFLARKQHRPRYQGI------------- 835
            :.|          :.|||         .|.| ||..||.|||:.::.|.:.|
  Fly   855 HSISGIQTYARGMLARNKFHAMRDHYRAVQI-QRFVRGALARRAYQKRRRNIIICQAAIRRFLAR 918

  Fly   836 GKINKIRTNTLKTIEIASGLKMGRE-EIISGVNDIYRQIDD---------------AIKKIKMNP 884
            .|..:::... |||.......||.| :|||    :.::||:               ::.|:|:.
  Fly   919 RKFKRMKAEA-KTISHMENKYMGLENKIIS----MQQRIDELNRDNSNLKHKTSEISVLKMKLE- 977

  Fly   885 RITQREMDSMYTVVMA---NMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQ 946
              .::.:::.:..|.|   :.:||...||    :|.:||..|:::.::|...|:   :|...|:|
  Fly   978 --LKKTLEAEFKNVKAACQDKDKLIEALN----KQLEAERDEKMQLLEENGHAQ---EEWISQKQ 1033

  Fly   947 REEIENKRLKAEME---TRRKAAEAQRLRQEE------EDRRAALALQEQL-EKEAKDDAKYRQQ 1001
            ....||:.|:.:::   ...|.||..:..||:      ::|....|.|..: :||..::..:..:
  Fly  1034 TWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLK 1098

  Fly  1002 LEQER---RDHELALRLANESNGQVEDS--------------PPVIRN---GVNDASPMGPNKLI 1046
            .|..|   ....|..|.|:.::.|.||.              ||.:.:   ..||::.:    ::
  Fly  1099 EELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSL----VV 1159

  Fly  1047 SFSQVVS--------------NIASRYLNKSENVRAQQQALGKQKYDLSKWKYSELRDAINTSCD 1097
            ....::.              .::||:....::.|..:..:..:|.   :.:|.:||.:|....:
  Fly  1160 KLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKL---RSEYDQLRTSIKHGVE 1221

  Fly  1098 IELLE----ACRQEFHRR------------------------------------LKVYHAWKAKN 1122
            |..|.    |.::|..||                                    ::.:|:.|..|
  Fly  1222 INELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLIN 1286

  Fly  1123 R------KRTTMDENERAPRSVMEAAFKQPPLVQPIQEIVTAQHRYFRIPFMRANAPDNTKRGLW 1181
            |      |..|.:.|.:              ||:..|||            .|.|   |.|..|.
  Fly  1287 RQLESELKAITEEHNSK--------------LVEMTQEI------------ERLN---NEKDELQ 1322

  Fly  1182 YAHFDG----------------QWIARQMELHADKPPILLVAGTDDMQMCELSLEETGLTRKRGA 1230
            ...|:.                :::.|  ||.......|||  .:::::....|:   ..|:.|.
  Fly  1323 KVMFESIDEFEDSNVDTLRQNDRYLRR--ELQKAVAQFLLV--QEELKLANAKLK---AYRQDGG 1380

  Fly  1231 EILEHEFNREWERNGGKAYKNLGAAKPNGPAAAMQKQQ 1268
            : |||:...|..||     |:.|.:...|.....||.|
  Fly  1381 Q-LEHKIEEEMIRN-----KSNGTSADVGANVTKQKSQ 1412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	255/745 (34%)
		CBD_MYO6-like	765..913	CDD:409646	46/237 (19%)
		ERM_helical	<954..1020	CDD:466641	16/78 (21%)
		MYO6_MIU_linker	1002..1093	CDD:480843	19/124 (15%)
		MyUb_Myo6	1076..1116	CDD:439319	11/79 (14%)
		Myosin-VI_CBD	1160..1246	CDD:465157	21/101 (21%)
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	255/745 (34%)
		IQ	900..922	CDD:197470	3/21 (14%)
		SMC_prok_B	<942..1365	CDD:274008	86/476 (18%)
		Myo5_CBD	1424..1792	CDD:271254