DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment jar and Mhc

DIOPT Version :9

Sequence 1:NP_001014650.2 Gene:jar / 42889 FlyBaseID:FBgn0011225 Length:1268 Species:Drosophila melanogaster
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:1515 Identity:411/1515 - (27%)
Similarity:644/1515 - (42%) Gaps:363/1515 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 WVRDAAEGYI-------QGRITEIGAKEFEV-----TPTDRKYPKRTCHFDDIHSSCDGPQDHDD 61
            |:.|..|||:       :|.|..:|.:..||     ...::..|.:   |:.|          :|
  Fly    39 WIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPK---FEKI----------ED 90

  Fly    62 NCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPH 126
            ..::.:||....|.||:.|||...||||.....:|:|||:.. .:|.....|.|.|:...|:|||
  Fly    91 MADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRY-PVYTNRCAKMYRGKRRNEVPPH 154

  Fly   127 VFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLC---------YSHDSAGPIETKI 182
            :|||:|.|..||....::||::::|||||||||:||.::.|..         .:..|.|.:|.::
  Fly   155 IFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQV 219

  Fly   183 LDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHV 247
            :..||||||||||||.||:|||||||||.:|:....::.|..|..|||||:|:.:|.:.||:||:
  Fly   220 VQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHI 284

  Fly   248 FYMLLAGAPQQLRDKLSLGKPD---DYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPI 309
            ||.:::|:...::|...|  .|   ||..:|                          :|.:....
  Fly   285 FYQIMSGSVPGVKDICLL--TDNIYDYHIVS--------------------------QGKVTVAS 321

  Fly   310 IDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRG-GCQVSEASEQSLT 373
            |||.:.|...|:|...||.:..||..:|.:.|||:|:|.:.|::     || ..|..:..|:...
  Fly   322 IDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQ-----RGREEQAEQDGEEEGG 381

  Fly   374 ITSGLLGVDQTEL-RTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVG 437
            ..|.|.|.|..|| :..|..|:  ..|..|    :.....:.:.:|:..||.|.::.|||..:|.
  Fly   382 RVSKLFGCDTAELYKNLLKPRI--KVGNEF----VTQGRNVQQVTNSIGALCKGVFDRLFKWLVK 440

  Fly   438 LINQSIPFQAS-NFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGL 501
            ..|:::..|.. ..:||||||||||.|..|.|||.|||:.|||||:|||.::...|||.|||||:
  Fly   441 KCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGI 505

  Fly   502 NVPEITF-TDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGL------ 559
            :...|.| .|....|:||| |..||.::|:|||..||.:...|:.::     .:..||.      
  Fly   506 DWAFIDFGMDLLACIDLIE-KPMGILSILEEESMFPKATDQTFSEKL-----TNTHLGKSAPFQK 564

  Fly   560 ---PRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF 621
               |:..:..||        |.:.|:||.|.||...::|||.|.|:.::....::..|.||..:|
  Fly   565 PKPPKPGQQAAH--------FAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIF 621

  Fly   622 -----PSGSSTSV---RGKL--NFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFE 676
                 .||.....   |||.  .|.:|.|.:|.||..||..|.....:|:|||.||........:
  Fly   622 ADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVD 686

  Fly   677 GSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPA-RTFCEAMFQSLNLS 740
            ..|.:.||.|:|.:..:.:...|:|:|:::.|....||.:.|..|..:.. :...|.:.:.::|.
  Fly   687 AHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKFIDLP 751

  Fly   741 AKDFKFGITKVFFRPG------------------------------------------------- 756
            ...::.|.||||||.|                                                 
  Fly   752 EDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRN 816

  Fly   757 --KFVEF----------------------DRIMRSD-----PENMLAIVAKVKKWL--IRSRWV- 789
              |:::.                      |.|.|.:     .|.:.|...||:|.|  :.::.: 
  Fly   817 LRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLA 881

  Fly   790 -KSAL--------GALCVIKLRNRIIYRNKCVL------IAQRI-----ARG--FLARKQHRPRY 832
             |:||        |||...:.||..:...|..|      |.:|:     ||.  |..:|:.....
  Fly   882 EKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEI 946

  Fly   833 QGIGK-INKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKI----KMNPRITQREMD 892
            .|:.| |..:..|..|    |...|..::..|..:||.....|:.|.|:    ||.....|:..:
  Fly   947 SGLKKDIEDLELNVQK----AEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGE 1007

  Fly   893 SMYTV--VMANMNKLTVDLNTKLKEQQQAEEQER----------------LRKIQEAL-EAERAA 938
            .:...  .:.::||:...|...|.|.:.:.|:|:                |:..|||: :.||..
  Fly  1008 ELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNK 1072

  Fly   939 KEAEE--QRQREEIEN-------------------KRLKAEMETRRKAAEAQR-LRQEEEDRRAA 981
            ||.|:  ||:.:|:.:                   |.|:|.:|...:..||:| .|.:.|.:||.
  Fly  1073 KELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRAD 1137

  Fly   982 LA-----LQEQLEK-------EAKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPPVIRNGV 1034
            ||     |.|:||:       :.:.:.|...:|.:.|||.|       |:|.|.|.:...:|...
  Fly  1138 LARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLE-------EANIQHESTLANLRKKH 1195

  Fly  1035 NDA-SPMGP-----NKLISFSQVVSNIASRYLNKSE-------NVRAQQQALGKQ---------- 1076
            ||| :.|..     |||.:.::...|.....||...       |.:|.|:.:.||          
  Fly  1196 NDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQS 1260

  Fly  1077 ----------KYDLSKWKYSELRDAINTSCDIELLEACRQEFHR--RLKVYHAWKAKNRKRTTMD 1129
                      .:|.||.|.|     |..|..:..||....:..:  ::|:....:.::.||.. |
  Fly  1261 KLDETNRTLNDFDASKKKLS-----IENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLA-D 1319

  Fly  1130 ENERAPRSVMEAAFKQ-----PPLVQPIQEIVTAQHRYFRIPFMRANAPDNTKRGLWYAHFDGQW 1189
            |..| .|:.:...|:.     ..|.:.::|....     :....|..:..|.:..:|.:.::...
  Fly  1320 EESR-ERATLLGKFRNLEHDLDNLREQVEEEAEG-----KADLQRQLSKANAEAQVWRSKYESDG 1378

  Fly  1190 IARQMELHADKPPI-LLVAGTDDM-----QMCELSLEETGLTRKRGAEILEHEFNREWERNGGKA 1248
            :||..||...|..: ..:|..::.     |.| :.||:|........|.|:.|.:|         
  Fly  1379 VARSEELEEAKRKLQARLAEAEETIESLNQKC-IGLEKTKQRLSTEVEDLQLEVDR--------- 1433

  Fly  1249 YKNLGAAKPNGPAAAMQKQQ 1268
                    .|..|.|.:|:|
  Fly  1434 --------ANAIANAAEKKQ 1445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
jarNP_001014650.2 Myosin_N 7..45 CDD:280832 11/47 (23%)
Myosin_head 59..754 CDD:278492 249/730 (34%)
MYSc_Myo6 71..754 CDD:276833 246/718 (34%)
RILP-like <968..1015 CDD:304877 18/59 (31%)
Myosin-VI_CBD 1160..1246 CDD:293129 18/91 (20%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 10/33 (30%)
MYSc 81..777 CDD:214580 255/762 (33%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 246/718 (34%)
Myosin_tail_1 842..1897 CDD:279860 145/645 (22%)
V_Alix_like 1557..1877 CDD:187408
ATP-synt_B <1671..1771 CDD:304375
TMPIT 1739..>1825 CDD:285135
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466281
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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