DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and d

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	906	Identity:	236/906 - (26%)
Similarity:	366/906 - (40%)	Gaps:	209/906 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PQDHDDNCELM-LLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRS 119
            |:|..|...|. .|.|...:..|:.|:.:.:.:|.|..||:::|||.::..   |.|:.......
  Fly   472 PKDMQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPYLDVGN---PLTLTSTRAMP 533

  Fly   120 LGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIET---- 180
            |.   |.:..|..:|:|........|:||:||.||||||.:...:|:.| ::....|| ||
  Fly   534 LA---PQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQL-FAIAGGGP-ETDAFK 593

  Fly   181 KILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGG-----YISHYLLEKSRICTQSA 240
            .:..|..||.:.|:||||.|:.|||.|:||||      ||..|     .|..|.|:::|:.....
  Fly   594 HLAAAFTVLRSLGSAKTTTNSESSRIGQFIEV------QVTDGALYRTKIHCYFLDQTRVIRPLP 652

  Fly   241 EERNYHVFYMLLAGAPQQLRDKLSLG--KPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKG 303
            :|:|||:||.||||..::.|.||.|.  .|.:.|||.|                 ...:|.|
  Fly   653 KEKNYHIFYQLLAGLSREERQKLHLDGYSPANLRYLRG-----------------DIGQNEQ--- 697

  Fly   304 PLKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEAS 368
                   :|...|......||.||:   ..|.:..::||||.|||:.|.:     .||.:|....
  Fly   698 -------EDAARFQAWKTCLGILGI---PFLDVVRVLAAVLLLGNVQFID-----GGGLEVDVKG 747

  Fly   369 EQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFD 433
            |..|...:.||||....|...|.:|.     ...:|.::.......:|:..||.||||:|.|...
  Fly   748 ETELNSVASLLGVPPAALFRGLTTRT-----HNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVA 807

  Fly   434 RIV------------------------------------------------GLINQSIPFQASNF 450
            .||                                                ..:|.::....|:.
  Fly   808 TIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDG 872

  Fly   451 YIGVLDIAGFEYFTVNS-FEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNV-PEITFTDNQD 513
            :||:||:.|||..:.:: .|..|||.|.|.:|.|:|.:|.|:..|..:.||:.. .|:.:.||..
  Fly   873 FIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVP 937

  Fly   514 IIELIEAKSNGIFTLLDEESKLPKPSYSHFT--AEVHKSWANHYRLGLPRSSRLKAHRTL--RDE 574
            .|:||.:...|:.::||.|..:...:.|:.|  ...|:|           |:||:...|.  .|.
  Fly   938 CIDLISSLRTGLLSMLDAECSVRGTAESYVTKLKVQHRS-----------STRLETKPTAEPHDP 991

  Fly   575 EGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLV------------------------QECDNP 615
            ..||:|||||.|.|:|..|::.|.|.:...|.|:.                        |:....
  Fly   992 RMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRG 1056

  Fly   616 LLQTLFPSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLA 680
            |...:.|:..|..:.|.....::...|.|:|..|:..|.....:|:|||:.|.....|.|:.:..
  Fly  1057 LSFRISPTSHSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATV 1121

  Fly   681 LAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSL---PARTFCE-----AMFQSL 737
            :.|::....:..:.||..|:|.|:.|....:.|:.:.|..|:..   .|...|:     ||.|..
  Fly  1122 VRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPP 1186

  Fly   738 NLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLR 802
            .|.      |...:.:.||                       |:.:..|..::..|.     .||
  Fly  1187 VLD------GSVTLAWAPG-----------------------KRHVFLSEGIRQHLE-----HLR 1217

  Fly   803 NRIIYRNKCVLIAQRIARGFLARKQ------HRPRYQGIGKI----NKIRTNTLKTIEIAS 853
            ..|  |:|...:.|...||:..||:      .|.:..|:.:.    ||...|:....:.||
  Fly  1218 TEI--RHKSATLMQATWRGWWWRKKMGNGGAKRSKIPGLQQAPLPNNKTTPNSAAQNKAAS 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	212/792 (27%)
		MYSc_Myo6	71..754	CDD:276833	208/779 (27%)
		RILP-like	<968..1015	CDD:304877
		Myosin-VI_CBD	1160..1246	CDD:293129
d	NP_001188730.1	MYSc	476..1217	CDD:214580	217/839 (26%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	211/811 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466236
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940