Protein Alignment jar and Myo3b

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_796350.2
• Gene: Myo3b / 329421
• MGIID: 2448580
• Length: 1333
• Species: Mus musculus
• Alignment Length: 1020
• Identity: 281/1020 - (27%)
• Similarity: 464/1020 - (45%)
• Gaps: 170/1020 - (16%)

  Fly    33 TPTDRKYPKRTCHFDDIHSSCDGPQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAV 97
            |..:|.:..|....:|....|    ..||...|.:|:|.|.:..|:.||....|||||.:||||:
Mouse   339 TRHERMHTGRPHRVEDAGKCC----LEDDLVNLEVLDEDTIIYWLQKRYADALIYTYVGDILIAL 399

  Fly    98 NPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTK 162
            ||::.: .:|:|...:.|:|......|||:||.||.|.:.:..:...|.|::|||||:|||||..
Mouse   400 NPFQNL-SIYSPQFSRLYHGVKRSSNPPHIFASADNAYQCLVTFSKDQCIVISGESGSGKTESAH 463

  Fly   163 YLLKYLCYSHDSAG-PIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYIS 226
            .::::|.:...:.. .:..|||..|.::||||||:|..|:|||||||::|:.:.....|:|..||
Mouse   464 LIVQHLTFLGKADNQTLRQKILQVNSLVEAFGNARTAINDNSSRFGKYLEMMFTPTGAVMGARIS 528

  Fly   227 HYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLR---DKLSLGKPDDYRYLSGCTQYFANAKTEQ 288
            .|||||||:..|:|.|:|:|:||.:.||...|.:   .:|...||.  ||::|        :||:
Mouse   529 EYLLEKSRVIQQAAGEKNFHIFYYIYAGLYHQKKLAEFRLPEEKPP--RYIAG--------ETER 583

  Fly   289 LIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAF-- 351
            ::......::::.:       .:..||...:      :|.:|.|...:|.::|.:|::|:|.|
Mouse   584 VMQDITSKESYRTQ-------FEAIQHCFKI------IGFADKEVHSVYRILAGILNIGSIEFAA 635

  Fly   352 ---------EEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVI 407
                     .|:|:        .||.|.:..:    |.:...||:.||.|..:.:     :|..|
Mouse   636 ISSQHQTDKSEVPN--------PEALENAACV----LCISSEELQEALTSHCVVT-----RGETI 683

  Fly   408 MVPLKIYEASNARDALAKAIYSRLFDRIVGLIN------QSIPFQASNFYIGVLDIAGFEYFTVN 466
            :....:..|.:.|||::||:|.|||..||..||      ::|........:|:|||.|||.|..|
Mouse   684 VRANTVDRAEDVRDAMSKALYGRLFSWIVNRINTLLQPDKNICSAEDRMNVGILDIFGFEDFQRN 748

  Fly   467 SFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDE 531
            ||||.|||..||::|.:||.::...||..||.||::...:.:.||:.::::...|..|:..||||
Mouse   749 SFEQLCINIANEQIQYYFNQHVFALEQMEYKNEGVDAVLVQYEDNRPLLDMFLQKPLGLLALLDE 813

  Fly   532 ESKLPKPSYSHFTAEVHKS------WANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNT 590
            ||:.|:.:......:...:      |.       |:...|          .|.::|:||.|.|:.
Mouse   814 ESRFPQGTDQTLVDKFEDNLRCKFFWR-------PKGVEL----------CFGIQHYAGPVLYDA 861

  Fly   591 EQFIEKNNDALHASLEGLVQECDNPLLQTLFP----------------SGSSTSV-------RGK 632
            ...:|||.|.|.|.:..:::..:|.|||.||.                :.||.|:       |.|
Mouse   862 SGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRAKITASSRSLPPHFSAGRAK 926

  Fly   633 LNFISV---------------GSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALA 682
            ::.:.|               .|.|:..|.:|:.|:.....:||||||||......||.....||
Mouse   927 VDTLEVIRHPEETTNMKRQTMASYFRYSLMDLLSKMVVGQPHFIRCIKPNDDRKALQFSQDRVLA 991

  Fly   683 QLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPA-RTFCEAMFQSLNLSAKDFKF 746
            ||:.:|.:..:.:...||..|:.|.:....|..:......:.|| :..|.|:.:...|.  .:..
Mouse   992 QLRSTGILETVSIRRQGYSHRIFFEEFVKRYYYLAFRAHQTPPANKESCVAILEKSRLD--HWVL 1054

  Fly   747 GITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKC 811
            |.||||.:.....:.:.::|.....::.:.|..|.|          |||....:.:.:   |.|.
Mouse  1055 GKTKVFLKYYHVEQLNLLLREVMGRVVMLQAYTKGW----------LGARRYKRAKEK---REKG 1106

  Fly   812 VLIAQRIARGFLARK----QHRPRYQGIGKINKIRTNT--LKTIEIASG-LKMGREEIISGVNDI 869
            .:..|...||:.||:    :.|.|.:....|:.:...|  .|....:.| ...|.||  :..|..
Mouse  1107 AITIQSAWRGYDARRKLKQRSRRRSESEAHIHTVLQTTPDQKYCPDSGGESNRGHEE--TSRNCP 1169

  Fly   870 YRQIDDAIKKIKMNPR---ITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEA 931
            .....|...:.:..|.   :|....|:.....:|.::....|::..| ....|...:||...:::
Mouse  1170 AEADTDGHPQAQSPPTGCDVTSGHADTAAGYTVAELSVAGTDVSPSL-VYHTASAHQRLSPCEDS 1233

  Fly   932 LEAERAAKEAEEQRQREEIENKRLKAEMETRRKAAEAQRLRQEEE 976
            |:.  .::|...|:||            ..||:..:.:.|...|:
Mouse  1234 LKP--GSEEGLSQKQR------------APRRRCQQPKMLSSPED 1264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	3/15 (20%)
		MYSc_Myo6	71..754	CDD:276833	228/748 (30%)
		CBD_MYO6-like	765..913	CDD:409646	30/157 (19%)
		ERM_helical	<954..1020	CDD:466641	4/23 (17%)
		MYO6_MIU_linker	1002..1093	CDD:480843
		MyUb_Myo6	1076..1116	CDD:439319
		Myosin-VI_CBD	1160..1246	CDD:465157
Myo3b	NP_796350.2	STKc_myosinIIIB_N	20..310	CDD:270808
		MYSc_Myo3	373..1062	CDD:276830	228/748 (30%)