DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and Myo10A

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster

Alignment Length:	967	Identity:	300/967 - (31%)
Similarity:	443/967 - (45%)	Gaps:	209/967 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DIHSSCDGPQDH---DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAP 109
            |:.||  |.:|.   ||      |:||:.|.||:.||.|..|||:..:||||||||:...:.|..
  Fly   151 DLGSS--GVEDMTLLDD------LHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGL 207

  Fly   110 DTIKKYNGRSLGELPPHVFAI---ADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYS 171
            :..|:|.||.||.||||:|||   |..|:...:|      :::|||||:|||||||.:::||...
  Fly   208 EVAKQYAGRPLGSLPPHLFAIGAAAHAALPSPQV------VVISGESGSGKTESTKLVMQYLAAV 266

  Fly   172 HDSAGP----IETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEK 232
            ....|.    |..:||:|.|:|||||||:|.||:|||||||::||::.:.. :||..|:.|||||
  Fly   267 VPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGA-IVGAKITQYLLEK 330

  Fly   233 SRICTQSAEERNYHVFYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSK 297
            |||.||:..||||||||.||.|..:..|.|..|.:.|.|.||:......|:.:.:
  Fly   331 SRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD---------- 385

  Fly   298 NHQQKGPLKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGC 362
                              :.:|..|:..||:|:.|:.||..::||||||||:.|..  ..:|.|.
  Fly   386 ------------------WESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHR--RQLRHGQ 430

  Fly   363 Q-VSEASEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKA 426
            : |...|:..:...:.||.:....|..||.||..::     :...:..||.|.:|.:||||.|||
  Fly   431 EGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEA-----RAERLHTPLGIDQALDARDAFAKA 490

  Fly   427 IYSRLFDRIVGLINQSIPFQASN--FYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNIL 489
            :|:.||:.:|..||..:....::  ..|.:|||.|||....|||||.||||.||.||.:||.::.
  Fly   491 LYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVF 555

  Fly   490 KNEQELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANH 554
            |.||..|.||.|....:.:.||..:|.|:..|..||..|||:||..|:.:...|..:.|   .||
  Fly   556 KLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCH---YNH 617

  Fly   555 YRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQT 619
                  ..|.|.|...:..:| |.|.|:||.|.|..:.|::||.|||...:..|:.....||:..
  Fly   618 ------ALSELYARPRIGAQE-FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGE 675

  Fly   620 L-------------FPSGSS-TSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKM 670
            |             .|.||: ..|..|....:|.::|...|.:|::.:.:....|:||||||.:.
  Fly   676 LTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEK 740

  Fly   671 IDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELV-SLPARTFCEAMF 734
            ...:.:....|.||:..|.:..:::.:.|||.|:.|......|:.:||..|. ..|.|..|.|:.
  Fly   741 HALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALL 805

  Fly   735 QSL---NLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGAL 796
            :::   .:...|::.|.|:||.|..    ..|.:.|.....|
  Fly   806 EAMPRTGVEGPDYQLGATRVFLREA----LHRALESGRTERL----------------------- 843

  Fly   797 CVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREE 861
                        .:..:..||..||.|.|:|
  Fly   844 ------------RRAAVSVQRHVRGMLVRRQ---------------------------------- 862

  Fly   862 IISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLR 926
                                                 :|........|..:.:.|:..:..||||
  Fly   863 -------------------------------------LARRQAAATRLQARWRGQRAQQRYERLR 890

  Fly   927 KIQEALEAERAAKEAEEQRQREEIENKRLKAEMETRRKAAE-AQRLRQEEEDRRAAL 982
            |  .||.|:|..:..:.:|:.::     |:::...|::|.| |||.|:..|.::|.|
  Fly   891 K--GALTAQRLWRGRQARRRVQQ-----LRSDHRRRQEAREAAQRAREAREAKQAVL 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	260/725 (36%)
		MYSc_Myo6	71..754	CDD:276833	256/710 (36%)
		RILP-like	<968..1015	CDD:304877	7/15 (47%)
		Myosin-VI_CBD	1160..1246	CDD:293129
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	264/741 (36%)
		MYSc_Myo15	169..828	CDD:276838	256/710 (36%)
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466287
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1389at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950