Protein Alignment jar and Myo6

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_008764645.1
• Gene: Myo6 / 315840
• RGDID: 1560646
• Length: 1294
• Species: Rattus norvegicus
• Alignment Length: 1313
• Identity: 670/1313 - (51%)
• Similarity: 900/1313 - (68%)
• Gaps: 72/1313 - (5%)

  Fly     2 LEDTQLVWVRDAAEGYIQGRITEIGAKEFEVTPTDRK-----------YPKRTCHFDDIHSSCDG 55
            :||.:.||.....:|:..|.|.:||.....:.|.::|           :|...          |.
  Rat     1 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEE----------DS 55

  Fly    56 PQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSL 120
            .:|.:|||.||.|||||.|.|:|.||.||:|||||||||||||||.:|.::|:.||||.|.|:||
  Rat    56 KKDVEDNCSLMYLNEATLLHNVKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSDTIKSYQGKSL 120

  Fly   121 GELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETKILDA 185
            |.:|||||||||||.|||:|.|:||||||||||||||||:||::|:||..|:.:...|:.:|::|
  Rat   121 GTMPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDDRIVEA 185

  Fly   186 NPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYM 250
            ||:|||||||||.|||||||||||:|:|::.|..||||::|||||||||||.|..||||||:||.
  Rat   186 NPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYR 250

  Fly   251 LLAGAPQQLRDKLSLGKPDDYRYLS-GCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQ 314
            |.|||.:.:|:||.|..||::|||: |||:||||.:|::.|..::||..:.:.|.||||::||:.
  Rat   251 LCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYVKAGSLKDPLLDDHG 315

  Fly   315 HFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLL 379
            .|..:..|:.::||.|.|||.::.:||.|||||||.||| .....|||.:...|..||...:.||
  Rat   316 DFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEE-AGSTSGGCNLKNKSAPSLEYCAELL 379

  Fly   380 GVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIP 444
            |:||.:||.:|.:|||.:..||.|||||.||||:.:|::|||||||.:||.|||.:|..:||..|
  Rat   380 GLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANSARDALAKTVYSHLFDHVVDRVNQCFP 444

  Fly   445 FQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFT 509
            |:.|:::||||||||||||..||||||||||||||||:|||:.|||.|||||::|||.|.|:.:.
  Rat   445 FETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYV 509

  Fly   510 DNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDE 574
            ||||.|:|||.|..||..:||||::||:||..|||:.||:...:|:||.:||.|:|..||.|||:
  Rat   510 DNQDCIDLIEVKLVGILDILDEENRLPQPSDQHFTSVVHQKHKDHFRLTIPRKSKLAVHRNLRDD 574

  Fly   575 EGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTS-----VRGKLN 634
            |||::|||||||||.|.||:||||||||.|||.|:.|..:..::.||.|.::.:     ..|||:
  Rat   575 EGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRALFESSTNNNKDTKQKAGKLS 639

  Fly   635 FISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHG 699
            |||||:||||||..|::||...|.:||||||||.||....|||:..|:||:|||.:|||:||:.|
  Rat   640 FISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGG 704

  Fly   700 YPSRVLFADLYSMYKSVLPPELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRI 764
            :|||..|.:||:|||..:|.:|..|..|.||:|:|::|.|:..|:|||:||||||||||.|||:|
  Rat   705 FPSRASFHELYNMYKKYMPEKLARLDPRLFCKALFKALGLNEVDYKFGLTKVFFRPGKFAEFDQI 769

  Fly   765 MRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHR 829
            |:|||:::..:|.:|..||:.|||.|....:|.||||:|:|.||.:..:..|:..|.:|.:::|:
  Rat   770 MKSDPDHLAELVKRVNLWLVCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHK 834

  Fly   830 PRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSM 894
            ||..|:.|:..::....|..|:.|.||.|:.|:...:.|:...||..:.||| :..:|:.::...
  Rat   835 PRIDGLVKVGTLKKRLDKFNEVVSALKDGKPEVNRQIKDLEISIDALMAKIK-STMMTREQIQKE 898

  Fly   895 YTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEM 959
            |..::.:...|   |:...|::||.||.||||:|||.:|.||..:|.:|||:|:|.|.:|:|.||
  Rat   899 YDALVKSSEDL---LSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEQRRRKEEEERRMKLEM 960

  Fly   960 ETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVE 1024
            |.:||..|.:|.::|::::|....::.||.::.:::::.:..|.||.||.|||||:|...:..:.
  Rat   961 EVKRKQEEEERKKREDDEKRIQAEVEAQLARQREEESQQQAVLAQECRDRELALRIAQNESELIS 1025

  Fly  1025 D---SPPVIRNG--------VNDASP-MGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQK 1077
            |   ....:|:.        .|...| |.|.::   ::.:|:|.||    ...|:|.:.|.|.:|
  Rat  1026 DEAQGDTALRSSSSCPASSKTNGTRPQMTPEQM---AKEMSDILSR----GPAVQATKAAAGTKK 1083

  Fly  1078 YDLSKWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENERAPRSVMEAA 1142
            :|||||||:||||.||||||||||.|||:|||||||||||||:||:||.|..| :|||:||.:..
  Rat  1084 HDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETE-QRAPKSVTDYD 1147

  Fly  1143 F--------KQPPLVQ-PI--QEI-VTAQHRYFRIPFMRA----NAPDNTKRGLWYAHFDGQWIA 1191
            |        :|.|..| |.  ||| :..|.|:|||||:|.    ..|.|.|:|.|||||||.|||
  Rat  1148 FAPFLNNSPQQNPAAQLPARQQEIEMNRQQRFFRIPFIRPADQYKDPQNKKKGWWYAHFDGPWIA 1212

  Fly  1192 RQMELHADKPPILLVAGTDDMQMCELSLEETGLTRKRGAEILEHEFNREWERNGGKAYKNLG--- 1253
            ||||||.||||||||||.|||:||||:|||||||||||||||..:|...|||.||..|....
  Rat  1213 RQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQYLQSAIES 1277

  Fly  1254 -AAKPNGPAAAMQ 1265
             .|:|....|.:|
  Rat  1278 RQARPTYATAMLQ 1290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/52 (19%)
		MYSc_Myo6	71..754	CDD:276833	404/688 (59%)
		CBD_MYO6-like	765..913	CDD:409646	46/147 (31%)
		ERM_helical	<954..1020	CDD:466641	24/65 (37%)
		MYO6_MIU_linker	1002..1093	CDD:480843	37/102 (36%)
		MyUb_Myo6	1076..1116	CDD:439319	33/39 (85%)
		Myosin-VI_CBD	1160..1246	CDD:465157	63/89 (71%)
Myo6	XP_008764645.1	MYSc_Myo6	71..759	CDD:276833	404/688 (59%)
		CBD_MYO6-like	770..917	CDD:409646	47/150 (31%)
		MYO6_MIU_linker	999..1068	CDD:412090	19/71 (27%)
		MyUb_Myo6	1082..1122	CDD:439319	33/39 (85%)
		Myosin-VI_CBD	1177..1267	CDD:465157	63/89 (71%)