DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and Myo1f

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001101546.1	Gene:	Myo1f / 314654	RGDID:	1309750	Length:	1098	Species:	Rattus norvegicus

Alignment Length:	1065	Identity:	314/1065 - (29%)
Similarity:	491/1065 - (46%)	Gaps:	182/1065 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPD-TIKKYNGRSLGEL 123
            ||...|..:.|...:.||:.|:..|.|:||:.::||:|||::::.  |..| .|..|.|.:..|.
  Rat    20 DDMVLLPQITEDAIVSNLRKRFMDDYIFTYIGSVLISVNPFKQMP--YFTDREIDLYQGAAQYEN 82

  Fly   124 PPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY---SHDSAGPIETKILDA 185
            |||::|:.|...|:|.:...:|.:|:|||||||||.:.||::.|:..   ..|....::..||.:
  Rat    83 PPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGDKVQHVKDIILQS 147

  Fly   186 NPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYM 250
            ||:|||||||||.||||||||||:.|:.:....:..||.||::||||||:..|:..|||:|::|.
  Rat   148 NPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNFHIYYQ 212

  Fly   251 LLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQH 315
            ||.||.|:.:..|.|..||.|.||:                   :|..::.:|      .||...
  Rat   213 LLEGASQEQQQNLGLMTPDYYYYLN-------------------QSDTYKVEG------TDDRSD 252

  Fly   316 FHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAF-EEIPDDVRGGCQVSEASEQSLTITSGLL 379
            |:....|:..:|:..:.:..:..|||.:||||||:| ||       |......|...|...:.||
  Rat   253 FNETLNAMQVIGIPTSVQQLVLQLVAGILHLGNISFCEE-------GNYARVESVDLLAFPAYLL 310

  Fly   380 GVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIP 444
            |:|...|:..|.||.|.||.|| :...|.|.|.:.:|:..||||||.:|:||||.:|..||:::.
  Rat   311 GIDSGRLQEKLTSRKMDSKWGG-RSESIDVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQ 374

  Fly   445 FQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFT 509
            .....:.||||||.|||.|..|.|||||||:.|||||:.|.:..||.|||.|.:||:....|.:.
  Rat   375 KPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYF 439

  Fly   510 DNQDIIELIEAKSN--GIFTLLD-------------EESKLPKPSYSHFTAEVHKSWANHYRLGL 559
            :|:.:.:|||.|.|  ||.::||             :::.|.|...:..|.|...||:
  Rat   440 NNKIVCDLIENKLNPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNSWS------- 497

  Fly   560 PRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSG 624
                           .||::.|:||.|.|:...|.|:|.|.|.:.|..|:|..|...|:.|||..
  Rat   498 ---------------AGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQSSDQAFLRMLFPEK 547

  Fly   625 SSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGT 689
            .....:|:.:  :.|||.|.|..:|:..|::...::|||||||.....|.:|.|....|::..|.
  Rat   548 LDVDKKGRPS--TAGSKIKKQANDLVSTLKKCTPHYIRCIKPNETKRPRDWEESRVKHQVEYLGL 610

  Fly   690 ISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLP-----ARTFCEAMFQSLNLSAKDFKFGIT 749
            ...:.:...|:..|..|:.....| ::|.||  :.|     .|...:.:.:::|:....::.|.|
  Rat   611 RENIRVRRAGFAYRRQFSKFLQRY-AILTPE--TWPRWRGDERQGVQHLLRAVNMEPDQYQMGST 672

  Fly   750 KVF------------FRPGKFVEFDRI----------------MRSDPENMLAIVAKVKKWLIRS 786
            |||            .|..||..|.|.                ||.:..|:|....:.::..|..
  Rat   673 KVFVKNPESLFLLEEMRERKFDGFARTIQKAWRRHIAVRKYEEMREEASNILLNKKERRRNSINR 737

  Fly   787 RWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINK----IRTNTLK 847
            .:|...||    ::.|..:              |.|||:::.......:.|.::    |:.:.:.
  Rat   738 NFVGDYLG----LEERPEL--------------RQFLAKRERVDFADSVTKYDRRFKPIKRDLIL 784

  Fly   848 TIEIASGLKMGREEIISG-----VNDIYRQIDD--AIKKIKMNPR-----ITQRE-MDSMYTVVM 899
            |.:..  ..:|||::..|     |.::.::..:  |::.:.::.|     |.|.| .||....:.
  Rat   785 TPKCV--YVIGREKVKKGPEKGLVREVLKKKLEIQALRGVSLSTRQDDFFILQEEAADSFLESIF 847

  Fly   900 ANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEMETRRK 964
            .     |..::...|..::|..:.......:.|:. |..||.........:...|...::...:.
  Rat   848 K-----TEFVSLLCKRFEEAARRPLPLTFSDMLQF-RVKKEGWGGGSTRNVTFSRGTGDLAVLKA 906

  Fly   965 AAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLAN------ESNG-- 1021
            .:           |...:::.:.|.|..|...|...| .:.||..:...|.|.      ..||
  Rat   907 GS-----------RALTISIGDGLPKSTKPTRKGLAQ-GRPRRSAQAPTRAAPGPPRGLNRNGVP 959

  Fly  1022 ---QVEDSPPVIRNG-VNDASPMGP 1042
               ||...|..|.:| .:...|.||
  Rat   960 PSSQVRSLPMEITSGRSSQRPPRGP 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	253/730 (35%)
		MYSc_Myo6	71..754	CDD:276833	249/719 (35%)
		RILP-like	<968..1015	CDD:304877	8/46 (17%)
		Myosin-VI_CBD	1160..1246	CDD:293129
Myo1f	NP_001101546.1	MYSc	12..690	CDD:214580	253/731 (35%)
		MYSc_Myo1	31..677	CDD:276829	249/707 (35%)
		Myosin_TH1	717..899	CDD:283635	35/207 (17%)
		SH3_MyoIe_If_like	1045..1097	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010