Protein Alignment jar and Myo10

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001388751.1
• Gene: Myo10 / 310178
• RGDID: 1307193
• Length: 2060
• Species: Rattus norvegicus
• Alignment Length: 1164
• Identity: 360/1164 - (30%)
• Similarity: 557/1164 - (47%)
• Gaps: 218/1164 - (18%)

  Fly     8 VWVRD-----------AAEGYIQGRITEIGA----KEFEVTPTDRKYPKRTCHFDDIHSSCDGPQ 57
            ||:|:           .|||.:..: |:.|.    |:..:|      .::......:|.     :
  Rat    11 VWLRENGQHFPSTVNSCAEGVVVFQ-TDYGQVFTYKQSTIT------NQKVTAMHPLHE-----E 63

  Fly    58 DHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGE 122
            ..||...|..|:..:.:.||..||.:::||||:.:|:.:||||:.|..||...|:::|:...|||
  Rat    64 GVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSIIASVNPYQPIAGLYERATMEQYSRCHLGE 128

  Fly   123 LPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKY----------LCYSHDSAGP 177
            ||||:||||::..|.:.....:|.:::|||||||||||||.:||:          ||....|:.
  Rat   129 LPPHIFAIANECYRCLWKRHDNQCVLISGESGAGKTESTKLILKFLSVISQHSLDLCLQEKSSS- 192

  Fly   178 IETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEE 242
            :|..||.::|::||||||||..||||||||||::::...|..:.||.|..|||||:|:..|:..|
  Rat   193 VEQAILQSSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQGGRIVDYLLEKNRVVRQNPGE 257

  Fly   243 RNYHVFYMLLAGAPQQLRDKLSLGKPDDYRYL--SGCTQYFANAKTEQLIPGSQKSKNHQQKGPL 305
            ||||:||.||||..|..|::..|..|::|.||  ||||:
  Rat   258 RNYHIFYALLAGLDQGEREEFYLSLPENYHYLNQSGCTE-------------------------- 296

  Fly   306 KDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQ 370
             |..|.|.:.|..:.:|:..:..|..|...:..|:|.:||||||.|     ...||.|:|  .:.
  Rat   297 -DKTISDQESFRQVIEAMEVMQFSKEEVREVLRLLAGILHLGNIEF-----ITAGGAQIS--FKT 353

  Fly   371 SLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRI 435
            :|..::.|||:|.|:|..||..|.|     ..:|..|:.||.:.:|.::||:||.|:|:|.|:.:
  Rat   354 ALGRSAELLGLDPTQLTDALTQRSM-----FLRGEEILTPLSVQQAVDSRDSLAMALYARCFEWV 413

  Fly   436 VGLINQSIPFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREG 500
            :..||..|..:.....||:|||.|||.|.||.||||.|||.|||||::||.:|...||..|.|||
  Rat   414 IKKINSRIKGKDDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQLEYSREG 478

  Fly   501 LNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRL 565
            |...:|.:.||.:.::||| |..|:..|::|||..|:.:.|....::|...||::....||.:
  Rat   479 LVWEDIDWIDNGECLDLIE-KKLGLLALINEESHFPQATDSTLLEKLHNQHANNHFYVKPRVA-- 540

  Fly   566 KAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVR 630
                    ...|.|:|:||.|.|:....:|||.|.....|..|::|.....:..||...||.:.:
  Rat   541 --------VNNFGVKHYAGEVQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHISSRNNQ 597

  Fly   631 GKLNFIS------VGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGT 689
            ..|...|      |.|:||..|..||..|..:...|:||||||::.:..||:.::.|.||:.||.
  Rat   598 DTLKCGSKHRRPTVSSQFKDSLHSLMATLSSSNPFFVRCIKPNTQKMPDQFDQAVVLNQLRYSGM 662

  Fly   690 ISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLP--ARTFCEAMFQSLNLSAKDFKFGITKVF 752
            :..:.:.:.||..|..|.|.|..|| ||..:| :||  .|..|..:.|..:.|..:::.|.||||
  Rat   663 LETVRIRKAGYAVRRPFQDFYKRYK-VLMRDL-ALPEDIRGKCTVLLQFYDASNSEWQLGKTKVF 725

  Fly   753 FRPGKFVEFDRIMRSDPENMLAIV-AKVKKWLIRSRWVKSALGALCVIK------LRNRIIYRNK 810
            .|.....:.::....:.:....:: |.:..:|.|.::.|...|.:.:.|      .|.|.::..|
  Rat   726 LRESLEQKLEKRREEEIDRAAMVIRAHILGYLARKQYRKVLCGVVTIQKNYRAFLARKRFLHLKK 790

  Fly   811 CVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDD 875
            ..::.|:..||.||||                                          :|||:
  Rat   791 AAIVFQKQLRGRLARK------------------------------------------VYRQL-- 811

  Fly   876 AIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRK-IQEALEAERAAK 939
                     ...:||::.                ..:|:|:::.||:||.|| .|...:..||.:
  Rat   812 ---------LAEKRELEE----------------RKRLEEEKKREEEERERKRAQREADLLRAQQ 851

  Fly   940 EAEEQRQREEIENKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLE- 1003
            |||.::|:|      |:|..:.:|:|...:.|.::.|:::....|  :||||.:|..:.::|.|
  Rat   852 EAETRKQQE------LEALQKNQREADLTRELEKQRENKQVEEIL--RLEKEIEDLQRMKEQQEL 908

  Fly  1004 ----------QERRDHEL------ALRLANE--SNGQVEDSPPVIRNGVNDASPMGPNKLISFSQ 1050
                      |:.||.||      |.|.|.|  .:...::....:|| :..:..:|.......|:
  Rat   909 SLTEASLQKLQQLRDEELRRLEDEACRAAQEFLESLNFDEIDECVRN-IERSLSVGSEISGELSE 972

  Fly  1051 VVSNIASRYLN-----------KSENVRAQQQALGKQKYDLSKWKYSELR-DAINTSCD 1097
            :..|.:....|           ..|...|...|. |...:.|:..:|:.| ..|.||.|
  Rat   973 LAENASGEKPNFNFSQPYPEEEVDEGFEADDDAF-KDSPNPSEHGHSDQRTSGIRTSDD 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/55 (18%)
		MYSc_Myo6	71..754	CDD:276833	267/702 (38%)
		CBD_MYO6-like	765..913	CDD:409646	21/154 (14%)
		ERM_helical	<954..1020	CDD:466641	23/84 (27%)
		MYO6_MIU_linker	1002..1093	CDD:480843	23/121 (19%)
		MyUb_Myo6	1076..1116	CDD:439319	7/23 (30%)
		Myosin-VI_CBD	1160..1246	CDD:465157
Myo10	NP_001388751.1	SH3_19	7..58	CDD:465815	10/53 (19%)
		MYSc_Myo10	77..727	CDD:276840	267/702 (38%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	619..641		10/21 (48%)
		PTZ00121	<726..1035	CDD:173412	78/384 (20%)
		SAH. /evidence=ECO:0000250|UniProtKB:Q9HD67	814..882		23/89 (26%)
		Smc	<840..>981	CDD:440809	36/149 (24%)
		MYO10_CC	882..932	CDD:465249	14/51 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	971..1039		14/61 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1064..1088
		PH-like	1183..>1225	CDD:473070
		PH2_MyoX	1217..1318	CDD:270108
		PH3_MyoX-like	1383..1508	CDD:270109
		MyTH4	1551..1697	CDD:214535
		FERM_F1_Myosin-X	1699..1794	CDD:340726
		B41	1706..1960	CDD:214604
		FERM_C_MyoX	1956..2044	CDD:270023