DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and Myo1a

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_062197.1	Gene:	Myo1a / 299509	RGDID:	3135	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	1132	Identity:	334/1132 - (29%)
Similarity:	540/1132 - (47%)	Gaps:	200/1132 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DGPQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGR 118
            :|....:|...|..|:|.:.:.||:.||.|.:||||:.|::|::|||::: .:|.|:.|.||...
  Rat     5 EGSVGVEDLILLEPLDEESLIKNLQLRYEKKEIYTYIGNVVISMNPYQQL-PIYGPEFIAKYRDY 68

  Fly   119 SLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKY---LCYSHDSAGPIET 180
            :..||.||::|:|:.|.:.::.....|.|:::|||||||||::|.::.|   :|...:....::.
  Rat    69 TFYELKPHIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAVCGKGEQVNSVKE 133

  Fly   181 KILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNY 245
            ::|.:||||||||||||.||:|||||||::::.:|.|...:||.|::|||||||:..|...|||:
  Rat   134 QLLQSNPVLEAFGNAKTIRNDNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGERNF 198

  Fly   246 HVFYMLLAGAPQQLRDKLSLGKPDD---YRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKD 307
            |:||.|||||..||...|.|  .:|   |.||:|                    :..:..|
  Rat   199 HIFYQLLAGADTQLLKALKL--EEDARGYAYLNG--------------------EVSRVNG---- 237

  Fly   308 PIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVR-------GGCQ-- 363
              :||..:|..:..|:..:|.|:.|...:..:.|.||.|||:   ::.|:.:       |.|.
  Rat   238 --MDDASNFRAVQNAMAVIGFSEEEIRQVLEVTALVLKLGNV---KLADEFQANGLPASGVCDGK 297

  Fly   364 -VSEASEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAI 427
             :.|..|        ::|::..||..||.||.|::.    |..|:.| |.:.:|..|||||||.|
  Rat   298 GIQEIGE--------MMGLNSAELEKALCSRTMETG----KEKVVTV-LNVIQAQYARDALAKNI 349

  Fly   428 YSRLFDRIVGLINQSIPFQA--SNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILK 490
            ||||||.||..||:||....  ....:|||||.|||....||||||.|||||||||:.|.:..||
  Rat   350 YSRLFDWIVNRINESIKVGTGEKRKVMGVLDIYGFEILEDNSFEQFVINYCNEKLQQVFIELTLK 414

  Fly   491 NEQELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLP-KPSYSHFTAEVHKSWA-- 552
            .|||.|||||:...::.:.||..|.:|||....||..:||||...| ..|.:.|.|::::.::
  Rat   415 EEQEEYKREGIPWTKVEYFDNGIICDLIEHSQRGILAMLDEECLRPGVVSDTTFLAKLNQLFSKH 479

  Fly   553 NHYRLGLPRSSRLKAHRTLRDEEG---FLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDN 614
            :||...:.::::.:..||:    |   |.:.|:||.|.||...||:||||.|...|...:.:..:
  Rat   480 SHYESKVTQNAQRQYDRTM----GLSCFRICHYAGKVTYNVTSFIDKNNDLLFRDLSQTMWKAQH 540

  Fly   615 PLLQTLFPSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSL 679
            |||.:|||.|:......| ...:.|::||..:..||:.|.....|:|||||||.:....:|...|
  Rat   541 PLLHSLFPEGNPKEASLK-RPPTAGTQFKNSVAILMKNLYSKNPNYIRCIKPNDQQQQGRFTSEL 604

  Fly   680 ALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPA--------RTFCEAMFQS 736
            .:.|.:..|.:..:.:...||..|..:......|:      |:|...        |...|.:..|
  Rat   605 VMVQARYLGLLENVRVRRAGYAFRQAYKPFLERYR------LLSRSTWPRWNGEDREGVEKVLGS 663

  Fly   737 LNLSAKDFKFGITKVFFRPGK---FVEFDRIMRSDPENMLAIVAKV-KKWLIRSRWVKSALGALC 797
            |.||:::..:|.||:|.|..|   ::|..|.:|.  :.:..::.|| :.|..|:.:.:.....:.
  Rat   664 LILSSEELAYGRTKIFIRSPKTLFYLEEQRRLRL--QQLATLIQKVYRGWRCRTHYQQMRKSQIL 726

  Fly   798 VI-------------KLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTI 849
            :.             |:|:       .||:.|...||:.|||.:|..::
  Rat   727 ISAWFRGNKQKKHYGKIRS-------SVLLIQAFVRGWKARKNYRKYFR---------------- 768

  Fly   850 EIASGLKMGREEIISGVNDIYRQIDDA-IKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKL 913
               ||      ..|:..|.||:.|... :..:|.|...| :.:|:.:.......      .||..
  Rat   769 ---SG------AAITLANFIYQSITQKFLLNLKKNLPST-KVLDNTWPAAPYRC------FNTAN 817

  Fly   914 KEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEMETRRKAA------------ 966
            :|.|....|.:.:|.::.|          ..:|.:.:..|...:|:...:||:
  Rat   818 QELQHLFYQWKCKKYRDQL----------SPKQVQTLREKLCASELFKGKKASYLQSVPVPFRGD 872

  Fly   967 --------EAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQV 1023
                    :.|||:..||   ..:.:.:.::|..:.:.|...::....:.| :.|..|.:|..|:
  Rat   873 YVGLQGNPKLQRLKGREE---GPVLVADTVKKVNRGNGKTSSRILLLTKGH-VILTDAKKSQAQI 933

  Fly  1024 EDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQAL--GKQKYDLSKWKYS 1086
                 ||:  :.|.:.      :|.:.:...:.|.:|::..:..::...|  .....:|....|.
  Rat   934 -----VIK--LEDVAG------VSVTSLEDGLFSLHLSEMSSAASKGDILLISDHLVELLTKMYQ 985

  Fly  1087 ELRDAINTSCDIELLEACRQEFHRRLK 1113
            .:.||......:.:.|    :|..|.|
  Rat   986 AVLDATQRQLPVTVTE----KFSVRFK 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	263/726 (36%)
		MYSc_Myo6	71..754	CDD:276833	259/714 (36%)
		RILP-like	<968..1015	CDD:304877	9/46 (20%)
		Myosin-VI_CBD	1160..1246	CDD:293129
Myo1a	NP_062197.1	MYSc_Myo1	22..681	CDD:276829	259/714 (36%)
		IQ	742..764	CDD:197470	10/28 (36%)
		Myosin_TH1	847..1042	CDD:399188	31/183 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920