DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and Myo1g

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	XP_006251280.1	Gene:	Myo1g / 289785	RGDID:	1306016	Length:	1018	Species:	Rattus norvegicus

Alignment Length:	843	Identity:	279/843 - (33%)
Similarity:	422/843 - (50%)	Gaps:	127/843 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ELMLLNEAT---FLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPP 125
            :.:||::.|   |:.||:.|:.|.:||||:..:|::||||:|: .||.|:.|.||.||.|.|.||
  Rat    13 DFVLLDQLTMEEFMKNLQLRFEKGRIYTYIGEVLVSVNPYQEL-PLYGPEAIAKYQGRELYERPP 76

  Fly   126 HVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETK-----ILDA 185
            |::|:|:.|.:.|:.......|::||||||||||::|::::|:....:.:...|.:     :|.:
  Rat    77 HLYAVANAAYKAMKRRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDVLLKS 141

  Fly   186 NPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYM 250
            ..||||||||:|.||:|||||||::::::|.|...|||:|..|||||||:..|...|||:|.||.
  Rat   142 TCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPVGGHIHSYLLEKSRVLKQHVGERNFHAFYQ 206

  Fly   251 LLAGAPQQLRDKLSLGK-PDDYRYL---SGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIID 311
            ||.|:..|...:|.|.: |..|.:.   :|......||.      ||.: |:||
  Rat   207 LLRGSEDQELQELHLERNPAVYNFTRQGAGLNMGVHNAL------GSDE-KSHQ----------- 253

  Fly   312 DYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDD--VRGGCQVSEAS----EQ 370
                  .:.:|:..:|.|..|...|:.::||:||||||.|.|..::  .:||.:|::.:    ..
  Rat   254 ------GVMEAMKIIGFSPEEVESIHRILAAILHLGNIEFVETEENGPQKGGLEVADEALVGYVA 312

  Fly   371 SLTIT-SGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDR 434
            .||.| |.|:      ||| |::|.:.|.|    ..||.....:.|||.||||.|||:|.|||:.
  Rat   313 KLTATPSDLV------LRT-LLARTVASGG----REVIEKSHTVAEASYARDACAKAMYQRLFEW 366

  Fly   435 IVGLINQSIP-------FQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNE 492
            :|..||..:.       ....:..||||||.|||.|.|||||||||||||||||:.|...|||.|
  Rat   367 VVNKINSIMEPRDRDPRRDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQE 431

  Fly   493 QELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHF---TAEVHKSWANH 554
            ||.|:|||:....|.:.:|..|:||:|....||..:|||......|.....   |.:.|.....|
  Rat   432 QEEYEREGITWQSIEYFNNATIVELVEQPRRGILAVLDEACSTAGPITDRIFLQTLDTHHRHHPH 496

  Fly   555 YRLGLPRSSR--LKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLL 617
            |      |||  ....:|:.....|.::|:||.|.|:.|.||:||.|:|....:.|:....:|.|
  Rat   497 Y------SSRQLCPTDKTMEFGRDFQIKHYAGDVTYSVEGFIDKNRDSLFQDFKRLLYNSMDPTL 555

  Fly   618 QTLFPSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALA 682
            :.::|.|...........::.|:.||..:..|:|.|......::||||||...:..:.:.:....
  Rat   556 RAMWPDGQQDITEVTKRPLTAGTLFKNSMIALVENLASKEPFYVRCIKPNEDKVPGRLDEAHCRH 620

  Fly   683 QLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVL----PPELVSLPARTFCEAMFQSLNLSAKD 743
            |::..|.:..:.:...|:.||..:......||...    |..|:. ..|....|:.:...|.. |
  Rat   621 QVEYLGLLENVRVRRAGFASRQPYPRFLLRYKMTCEYTWPNHLLG-SDREAVSALLEQHGLQG-D 683

  Fly   744 FKFGITKVFFR-PGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIY 807
            ..||.:|:|.| |...|..::    ...:::.|:
  Rat   684 VAFGHSKLFIRSPRTLVTLEQ----SRAHLIPII------------------------------- 713

  Fly   808 RNKCVLIAQRIARGFLAR---KQHRPRYQGIG--KINKIRTNTLKTIEIASGLKMGREEIISG 865
                ||:.|:..||.|||   ::.|..|..:|  :.:|:|.:   .||:....:..|:..:.|
  Rat   714 ----VLLLQKAWRGTLARWRCRRLRAIYTIMGWFRRHKVRAH---LIELQRRFQAARQPPLYG 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	258/724 (36%)
		MYSc_Myo6	71..754	CDD:276833	256/717 (36%)
		RILP-like	<968..1015	CDD:304877
		Myosin-VI_CBD	1160..1246	CDD:293129
Myo1g	XP_006251280.1	MYSc	4..706	CDD:214580	261/740 (35%)
		MYSc_Myo1	23..694	CDD:276829	255/714 (36%)
		Myosin_TH1	815..1005	CDD:283635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010