DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and MYO1H

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	XP_011536525.1	Gene:	MYO1H / 283446	HGNCID:	13879	Length:	1044	Species:	Homo sapiens

Alignment Length:	1088	Identity:	325/1088 - (29%)
Similarity:	502/1088 - (46%)	Gaps:	204/1088 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 NEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADK 133
            :|:.|:|||:.|:.::.||||:..:|::||||:|: .:|....::.|.|.:..||||||:||||.
Human    24 SESAFVDNLRKRFSENLIYTYIGTLLVSVNPYQEL-GIYTVSQMELYQGVNFFELPPHVYAIADN 87

  Fly   134 AIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYL---CYSHDSAGPIETKILDANPVLEAFGNA 195
            |.|.|.....:..|::||||||||||::|.:|:|.   |....|......::|.:||||||||||
Human    88 AYRMMCAELNNHFILISGESGAGKTEASKKILEYFAVTCPMTQSLQIARDRLLFSNPVLEAFGNA 152

  Fly   196 KTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLR 260
            :|.||:|||||||::::.:|.:...|||:|..||:||||:..|:..|||:|:||.||||..::..
Human   153 RTLRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSRVVYQNEGERNFHIFYQLLAGGEEERL 217

  Fly   261 DKLSLGK-PDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALG 324
            ..|.|.: |..|:|||                         |....|:..|.|...:..:..|..
Human   218 SYLGLERDPQLYKYLS-------------------------QGHCAKESSISDKNDWKTVSNAFS 257

  Fly   325 RLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTELRTA 389
            .:..::.:...::.::|:|||||||.|||  ||  .||.....:.:...|.. ||||..:.|..|
Human   258 VIDFTEADLENLFGIIASVLHLGNIGFEE--DD--QGCATIPDTHEIKWIAK-LLGVHPSVLLEA 317

  Fly   390 LVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPFQ--ASNFYI 452
            |..|.:::     |...::.||.:..:..||||:|||:|.|.|..:|..||.|:..:  .....|
Human   318 LTHRKIEA-----KTEEVICPLTLELSVYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTRKTVI 377

  Fly   453 GVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDIIEL 517
            |:|||.|||.|..|.||||||||||||||:...:..||.||..|:.||:....|.:.:|:.|.:|
Human   378 GLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIKYFNNKIICDL 442

  Fly   518 IEAKSNGIFTLLDEESKLPKPSYS-HFTAEVHKSWANHYRLGLPRSSRLKAH---RTLRDEEG-- 576
            :|.:..||.::||||...|.|:.. .|..::.:....|            ||   |.|...:|
Human   443 VEERHKGIISILDEECIRPGPATDLSFLEKLEEKVGKH------------AHFETRKLAGPKGRK 495

  Fly   577 ------FLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVRGKLNF 635
                  |.:.|:||.|.|.|:.|:|||||.|:..|:.::.:..|.:|:..|   ....:..:...
Human   496 RIGWMEFRLLHYAGEVTYCTKGFLEKNNDLLYRHLKEVLCKSKNIILRECF---LLAELENRRRP 557

  Fly   636 ISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGY 700
            .:||::||..|..|:|.|.....::|||||||.:....:|:..|...|:|..|.:..|.:...|:
Human   558 PTVGTQFKNSLSSLLETLISKEPSYIRCIKPNDRKEPSKFDDFLIRHQIKYLGLMEHLRVRRAGF 622

  Fly   701 P---------------------SRVLFADLY-SMYKSVLP---PELVSLPARTFCEAMFQSLNLS 740
            .                     .|::.:..| ..|||:.|   |.....||.. .|.:.:.:...
Human   623 AYRRKYEHFLQRYLGVELSHWVERLMMSLFYKDRYKSLCPDTWPHWHGPPAEG-VERLIKYIGYK 686

  Fly   741 AKDFKFGITKVFFRPGK--FVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKL-- 801
            .:::|.|.||:|.|..:  |...|....|..:.:..|.|..|:.|.|..:||....|   |||
Human   687 PEEYKLGKTKIFIRFPRTLFATEDAFEFSKHQLVARIQATYKRCLGRREYVKKRQAA---IKLEA 748

  Fly   802 -------RNRIIYRNKCVLIAQRIARGFLARKQH------------RPRYQGIGKINKIRTNTLK 847
                   |..|..|...|.|.::..:||::|.:.            |..|     |..:|.:..|
Human   749 HWRGALARKAIQRRKWAVRIIRKFIKGFISRNKPLCPDNEEFIVFVRKNY-----ILNLRYHLPK 808

  Fly   848 TIEIASGLKMGREEIISGVNDIYRQI------------DDAIKKIKMNPRITQREM----DSMYT 896
            |:...|.|:  ...|:...:|:.|::            ..|.:|..|..::...|:    ...||
Human   809 TVLDKSWLR--PPGILENASDLLRKMCVRNLVQKYCRGITAERKAMMQQKVVTSEIFRGRKDGYT 871

  Fly   897 VVMANMNKLTV-------DLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKR 954
               .::|:..|       |:|.|:.:....|      |||..:...:..::..:.|||:.|
Human   872 ---ESLNQPFVNSRIDEGDINPKVLQLISHE------KIQYGVPVIKYDRKGFKARQRQLI---- 923

  Fly   955 LKAEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANES 1019
                  ..:|||....|                        ||.:|::|..      ||:..:.|
Human   924 ------LTQKAAYVVEL------------------------AKIKQKIEYS------ALKGVSTS 952

  Fly  1020 NGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASR-YLNKSENV 1066
            |  :.|...||.....|:...| :.::....|...:... .|.|.||:
Human   953 N--LSDGILVIHVSPEDSKQKG-DAVLQCGHVFEAVTKLVMLVKKENI 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	250/727 (34%)
		MYSc_Myo6	71..754	CDD:276833	249/725 (34%)
		RILP-like	<968..1015	CDD:304877	7/46 (15%)
		Myosin-VI_CBD	1160..1246	CDD:293129
MYO1H	XP_011536525.1	MYSc	8..711	CDD:214580	252/738 (34%)
		MYSc_Myo1	26..700	CDD:276829	249/725 (34%)
		Myosin_TH1	856..1019	CDD:283635	38/194 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920