Protein Alignment jar and MYO1H

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_011536525.1
• Gene: MYO1H / 283446
• HGNCID: 13879
• Length: 1044
• Species: Homo sapiens
• Alignment Length: 1088
• Identity: 325/1088 - (29%)
• Similarity: 502/1088 - (46%)
• Gaps: 204/1088 - (18%)

  Fly    69 NEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADK 133
            :|:.|:|||:.|:.::.||||:..:|::||||:|: .:|....::.|.|.:..||||||:||||.
Human    24 SESAFVDNLRKRFSENLIYTYIGTLLVSVNPYQEL-GIYTVSQMELYQGVNFFELPPHVYAIADN 87

  Fly   134 AIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYL---CYSHDSAGPIETKILDANPVLEAFGNA 195
            |.|.|.....:..|::||||||||||::|.:|:|.   |....|......::|.:||||||||||
Human    88 AYRMMCAELNNHFILISGESGAGKTEASKKILEYFAVTCPMTQSLQIARDRLLFSNPVLEAFGNA 152

  Fly   196 KTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLR 260
            :|.||:|||||||::::.:|.:...|||:|..||:||||:..|:..|||:|:||.||||..::..
Human   153 RTLRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSRVVYQNEGERNFHIFYQLLAGGEEERL 217

  Fly   261 DKLSLGK-PDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALG 324
            ..|.|.: |..|:|||                         |....|:..|.|...:..:..|..
Human   218 SYLGLERDPQLYKYLS-------------------------QGHCAKESSISDKNDWKTVSNAFS 257

  Fly   325 RLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTELRTA 389
            .:..::.:...::.::|:|||||||.|||  ||  .||.....:.:...|.. ||||..:.|..|
Human   258 VIDFTEADLENLFGIIASVLHLGNIGFEE--DD--QGCATIPDTHEIKWIAK-LLGVHPSVLLEA 317

  Fly   390 LVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPFQ--ASNFYI 452
            |..|.:::     |...::.||.:..:..||||:|||:|.|.|..:|..||.|:..:  .....|
Human   318 LTHRKIEA-----KTEEVICPLTLELSVYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTRKTVI 377

  Fly   453 GVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDIIEL 517
            |:|||.|||.|..|.||||||||||||||:...:..||.||..|:.||:....|.:.:|:.|.:|
Human   378 GLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIKYFNNKIICDL 442

  Fly   518 IEAKSNGIFTLLDEESKLPKPSYS-HFTAEVHKSWANHYRLGLPRSSRLKAH---RTLRDEEG-- 576
            :|.:..||.::||||...|.|:.. .|..::.:....|            ||   |.|...:|
Human   443 VEERHKGIISILDEECIRPGPATDLSFLEKLEEKVGKH------------AHFETRKLAGPKGRK 495

  Fly   577 ------FLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVRGKLNF 635
                  |.:.|:||.|.|.|:.|:|||||.|:..|:.::.:..|.:|:..|   ....:..:...
Human   496 RIGWMEFRLLHYAGEVTYCTKGFLEKNNDLLYRHLKEVLCKSKNIILRECF---LLAELENRRRP 557

  Fly   636 ISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGY 700
            .:||::||..|..|:|.|.....::|||||||.:....:|:..|...|:|..|.:..|.:...|:
Human   558 PTVGTQFKNSLSSLLETLISKEPSYIRCIKPNDRKEPSKFDDFLIRHQIKYLGLMEHLRVRRAGF 622

  Fly   701 P---------------------SRVLFADLY-SMYKSVLP---PELVSLPARTFCEAMFQSLNLS 740
            .                     .|::.:..| ..|||:.|   |.....||.. .|.:.:.:...
Human   623 AYRRKYEHFLQRYLGVELSHWVERLMMSLFYKDRYKSLCPDTWPHWHGPPAEG-VERLIKYIGYK 686

  Fly   741 AKDFKFGITKVFFRPGK--FVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKL-- 801
            .:::|.|.||:|.|..:  |...|....|..:.:..|.|..|:.|.|..:||....|   |||
Human   687 PEEYKLGKTKIFIRFPRTLFATEDAFEFSKHQLVARIQATYKRCLGRREYVKKRQAA---IKLEA 748

  Fly   802 -------RNRIIYRNKCVLIAQRIARGFLARKQH------------RPRYQGIGKINKIRTNTLK 847
                   |..|..|...|.|.::..:||::|.:.            |..|     |..:|.:..|
Human   749 HWRGALARKAIQRRKWAVRIIRKFIKGFISRNKPLCPDNEEFIVFVRKNY-----ILNLRYHLPK 808

  Fly   848 TIEIASGLKMGREEIISGVNDIYRQI------------DDAIKKIKMNPRITQREM----DSMYT 896
            |:...|.|:  ...|:...:|:.|::            ..|.:|..|..::...|:    ...||
Human   809 TVLDKSWLR--PPGILENASDLLRKMCVRNLVQKYCRGITAERKAMMQQKVVTSEIFRGRKDGYT 871

  Fly   897 VVMANMNKLTV-------DLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKR 954
               .::|:..|       |:|.|:.:....|      |||..:...:..::..:.|||:.|
Human   872 ---ESLNQPFVNSRIDEGDINPKVLQLISHE------KIQYGVPVIKYDRKGFKARQRQLI---- 923

  Fly   955 LKAEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANES 1019
                  ..:|||....|                        ||.:|::|..      ||:..:.|
Human   924 ------LTQKAAYVVEL------------------------AKIKQKIEYS------ALKGVSTS 952

  Fly  1020 NGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASR-YLNKSENV 1066
            |  :.|...||.....|:...| :.::....|...:... .|.|.||:
Human   953 N--LSDGILVIHVSPEDSKQKG-DAVLQCGHVFEAVTKLVMLVKKENI 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	249/725 (34%)
		CBD_MYO6-like	765..913	CDD:409646	41/191 (21%)
		ERM_helical	<954..1020	CDD:466641	10/65 (15%)
		MYO6_MIU_linker	1002..1093	CDD:480843	15/66 (23%)
		MyUb_Myo6	1076..1116	CDD:439319
		Myosin-VI_CBD	1160..1246	CDD:465157
MYO1H	XP_011536525.1	MYSc_Myo1	26..700	CDD:276829	249/725 (34%)
		Adgb_C_mid-like	<696..>763	CDD:412094	19/69 (28%)
		globin helix H	696..720	CDD:412094	6/23 (26%)
		IQ motif	744..762	CDD:412094	5/17 (29%)
		Myosin_TH1	856..1037	CDD:461801	38/194 (20%)