DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and Myo95E

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster

Alignment Length:	1031	Identity:	237/1031 - (22%)
Similarity:	381/1031 - (36%)	Gaps:	368/1031 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 DNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPP 125
            |:..|..|:|.:|::|:..||.:|.||||:...::|:|||..|.| ::.|.::.|..:.:.:|||
  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISE-HSLDNVRNYGDKGIFQLPP 72

  Fly   126 HVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHD----------------- 173
            |::.:.:.|.:.::.....|.::::|||||||||:.|.::.:|.:..|
  Fly    73 HIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSST 137

  Fly   174 --------------------------------------------SAGP----------------- 177
                                                        |.||
  Fly   138 SSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRR 202

  Fly   178 -IETKILD--------------------------------------------------------- 184
             :..||:|
  Fly   203 HMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPT 267

  Fly   185 -----------------------------------------ANPV-------------------- 188
                                                     .||.
  Fly   268 VYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQP 332

  Fly   189 ----------------------------------------------------------------- 188

  Fly   333 ERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVT 397

  Fly   189 -----LEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVF 248
                 |||.|||.|.:||||||:||..::..|.|...:|.:|:||:|||:||......|||:|:|
  Fly   398 CADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIF 462

  Fly   249 YMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDY 313
            |.||.||..||...|.|     ||          |.:..:|:..:...:             :|.
  Fly   463 YQLLLGADLQLLKSLKL-----YR----------NVEKYELLRNTTAME-------------EDR 499

  Fly   314 QHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPD-DVRGGCQVSEASEQSLTITSG 377
            .:||...::|..||||..|...|:.::|.||.|||..|..|.: |...|||||...|  :..|:.
  Fly   500 MNFHYTKRSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYE--VQETAQ 562

  Fly   378 LLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQS 442
            ||.::    ...|::.:.::.........:...:...:|:..|:.|.:.:|||||..:|..||:|
  Fly   563 LLNME----AQILINCLTRANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINES 623

  Fly   443 IPFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEIT 507
            :........:.:||..|||....||||||.|||..||:.:.|..::|::|||||.||||....|.
  Fly   624 LKSTQREKNLALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRID 688

  Fly   508 FTDNQDIIELIEAKSNGIFTLLDEESKLPKP---SYSHFTAEVHKSWANHYRLGLPRSSRLKAHR 569
            :.||:.|.|||:..|.||.:|::|      |   |.......|.:..|.|.......|:.:
  Fly   689 YFDNESICELIDKPSYGILSLINE------PHLNSNDALLLRVQQCCAGHPNFMTTGSNSM---- 743

  Fly   570 TLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGS-STSVRGKL 633
                  .|.:||:|..|.|:..:|:|||:|.|...:.....:....|:|:|||.|: ...|..|.
  Fly   744 ------CFQIRHYASVVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKP 802

  Fly   634 NFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEH 698
            :.:|  |..:|||..|:..::...::::.|||||......||:.:|...|::....:.::.|...
  Fly   803 STLS--SNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRT 865

  Fly   699 GYPSRVLFADLYSMYK---SVLPP--------ELVSLPARTFCEAMFQSLNLSAKDFKFGITKVF 752
            |:...:|....:..||   |:..|        |.::|        :.::|.|.:.:|..|...||
  Fly   866 GHCYHLLHVKFFHRYKLLNSLTWPHFHGGSQVEGIAL--------IIRNLPLPSAEFTIGTKNVF 922

  Fly   753 FRPGKFV----EFDRIMRSDPENMLAIVAKV----------------KKWLIRSRW 788
            .|..:.|    :|.|:..|:    ||::.:.                .:.:|.|.|
  Fly   923 VRSPRTVYELEQFRRLRISE----LAVLIQTMFRMYHARKRFQRMRHSQMIISSAW 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	227/975 (23%)
		MYSc_Myo6	71..754	CDD:276833	223/965 (23%)
		RILP-like	<968..1015	CDD:304877
		Myosin-VI_CBD	1160..1246	CDD:293129
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	34/99 (34%)
		Motor_domain	403..924	CDD:277568	180/580 (31%)
		Myosin_TH1	1092..1267	CDD:283635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950