Protein Alignment jar and Myh9

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_037326.2
• Gene: Myh9 / 25745
• RGDID: 3140
• Length: 1960
• Species: Rattus norvegicus
• Alignment Length: 1249
• Identity: 370/1249 - (29%)
• Similarity: 581/1249 - (46%)
• Gaps: 258/1249 - (20%)

  Fly     6 QLVWVRDAAEGYIQGRITEIGAKE--FEVTPTDRKYPKRTCHFDDIHSSCDGPQ--DHDDNCELM 66
            :||||.....|:....:.|...:|  .|:....:|.   ..:.||| ...:.|:  ..:|..||.
  Rat    30 KLVWVPSTKNGFEPASLKEEVGEEAIVELVENGKKV---KVNKDDI-QKMNPPKFSKVEDMAELT 90

  Fly    67 LLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIA 131
            .||||:.|.|||.|||...||||.....:.:|||:.: .:|:.:.:..|.|:...|:|||::||.
  Rat    91 CLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNL-PIYSEEIVDMYKGKKRHEMPPHIYAIT 154

  Fly   132 DKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY---SHDS---AGPIETKILDANPVLE 190
            |.|.|.|...:..|||:.:|||||||||:||.:::||.:   ||.|   .|.:|.::|.|||:||
  Rat   155 DTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQLLQANPILE 219

  Fly   191 AFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGA 255
            |||||||.:|:|||||||||.:::|....:||..|..|||||||...|:.|||.:|:||.||:||
  Rat   220 AFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGA 284

  Fly   256 PQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLD 320
            .:.|:..|.|...:.||:||         .....|||.|                 |...|....
  Rat   285 GEHLKTDLLLEPYNKYRFLS---------NGHVTIPGQQ-----------------DKDMFQETM 323

  Fly   321 KALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTE 385
            :|:..:|:.:.|::|:..:::.||.||||.|::    .|...|.|.....:....|.|||::.|:
  Rat   324 EAMRIMGIPEDEQMGLLRVISGVLQLGNIVFKK----ERNTDQASMPDNTAAQKVSHLLGINVTD 384

  Fly   386 L-RTALVSRV---------MQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLIN 440
            . |..|..|:         .|:|               .:|..|.:|||||.|.|:|..:|..||
  Rat   385 FTRGILTPRIKVGRDYVQKAQTK---------------EQADFAIEALAKATYERMFRWLVLRIN 434

  Fly   441 QSI---PFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLN 502
            :::   ..|.::| ||:|||||||.|.:|||||.||||.|||||:.||..:...|||.|:|||:.
  Rat   435 KALDKTKRQGASF-IGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIE 498

  Fly   503 VPEITF-TDNQDIIELIE--AKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSR 564
            ...|.| .|.|..|:|||  |...||..|||||...||.:...|..:|.:....|.:...|:.
  Rat   499 WNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVEKVVQEQGTHPKFQKPKQ-- 561

  Fly   565 LKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFP------- 622
                  |:|:..|.:.|:||.|.|..::::.||.|.|:.::..|:.:..:..:..|:.
  Rat   562 ------LKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRIIG 620

  Fly   623 ----SG-SSTSVRG-----KLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEG 677
                :| |.|::.|     |..|.:||..:|.||.:||..|.....||:|||.||.:....:.:.
  Rat   621 LDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDP 685

  Fly   678 SLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVS--LPARTFCEAMFQSLNLS 740
            .|.|.||:|:|.:..:.:...|:|:||:|.:....|:.:.|..:..  :..:..|..|.::|.|.
  Rat   686 HLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQACVLMIKALELD 750

  Fly   741 AKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRI 805
            :..::.|.:|||||.|               :||.:.:.:.                 :|:.:.|
  Rat   751 SNLYRIGQSKVFFRAG---------------VLAHLEEERD-----------------LKITDVI 783

  Fly   806 IYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREE---IISGVN 867
            |....|       .||:||||....|.|.:..:..::.|      .|:.|::...:   :.:.|.
  Rat   784 IGFQAC-------CRGYLARKAFAKRQQQLTAMKVLQRN------CAAYLRLRNWQWWRLFTKVK 835

  Fly   868 DIYRQI---DDAI-----------KKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQ 918
            .:...|   |:.:           |.:....|:|  ||::|.:.:||  .||      :|:||.|
  Rat   836 PLLNSIRHEDELLAKEAELTKVREKHLAAENRLT--EMETMQSQLMA--EKL------QLQEQLQ 890

  Fly   919 AE-----EQERLR--------KIQEALEAERAAKEAEEQR--------------------QREEI 950
            ||     |.|.||        :::|......|..|.||:|                    |.||.
  Rat   891 AETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQYLQAEKKKMQQNIQELEEQLEEE 955

  Fly   951 ENKRLKAEMETRRKAAEAQRLRQEE---EDRRAALALQEQL---------------EKEAKDDAK 997
            |:.|.|.::|.....|:.::|.:::   ||:...||.:::|               |:::|..||
  Rat   956 ESARQKLQLEKVTTEAKLKKLEEDQIIMEDQNCKLAKEKKLLEDRVAEFTTNLMEEEEKSKSLAK 1020

  Fly   998 YRQQLEQERRDHELALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNK 1062
            .:.:.|....|.|..||...:...::|.:...:.....|.|    :::......::.:..:...|
  Rat  1021 LKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS----DQIAELQAQIAELKMQLAKK 1081

  Fly  1063 SENVR---------AQQQALGKQKYDLSKWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAW 1118
            .|.::         |.|:.:..:|....:.:.|||::      |:|...|||.
  Rat  1082 EEELQAALARVEEEAAQKNMALKKIRELETQISELQE------DLESERACRN------------ 1128

  Fly  1119 KAKNRKRTTMDENE 1132
            ||:.:||...:|.|
  Rat  1129 KAEKQKRDLGEELE 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/43 (23%)
		MYSc_Myo6	71..754	CDD:276833	257/723 (36%)
		CBD_MYO6-like	765..913	CDD:409646	30/164 (18%)
		ERM_helical	<954..1020	CDD:466641	19/83 (23%)
		MYO6_MIU_linker	1002..1093	CDD:480843	16/99 (16%)
		MyUb_Myo6	1076..1116	CDD:439319	9/39 (23%)
		Myosin-VI_CBD	1160..1246	CDD:465157
Myh9	NP_037326.2	Myosin_N	27..72	CDD:460670	10/44 (23%)
		Motor_domain	95..764	CDD:473979	257/723 (36%)
		Myosin_tail_1	842..1921	CDD:460256	72/333 (22%)