DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and Myo1e

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_775124.1	Gene:	Myo1e / 25484	RGDID:	3144	Length:	1107	Species:	Rattus norvegicus

Alignment Length:	1203	Identity:	333/1203 - (27%)
Similarity:	542/1203 - (45%)	Gaps:	248/1203 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELP 124
            ||...|..:.|::.::|||.||..|.|:||:.::||:|||:::: ..:....|:.|.|.:..|.|
  Rat    22 DDMVLLSKITESSIVENLKKRYMDDYIFTYIGSVLISVNPFKQM-PYFGEKEIEMYQGAAQYENP 85

  Fly   125 PHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAG-----PIETKILD 184
            ||::|:||...|:|.:.:.:|.:|:|||||||||.:.||::.|:  |..|.|     .::..||.
  Rat    86 PHIYALADSMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYV--SRVSGGGPKVQHVKDIILQ 148

  Fly   185 ANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFY 249
            :||:|||||||||.||||||||||:.|:.:....:..||.||::||||||:..::..||::|:||
  Rat   149 SNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFY 213

  Fly   250 MLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQ 314
            .|:.||..:.:..|.:...|.|.|||              :.||.|..:           |||.:
  Rat   214 QLIEGASPEQKQSLGITSMDYYYYLS--------------LSGSYKVDD-----------IDDKR 253

  Fly   315 HFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLL 379
            .|.....|:..:|:...|:..:..:||.:||||||.|:|:      |...:..||:.|...:.||
  Rat   254 DFQETLHAMNVIGIFSEEQTLVLQIVAGILHLGNINFKEV------GNYAAVESEEFLAFPAYLL 312

  Fly   380 GVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIP 444
            |::|..|:..|.||.|.||.|| |...|.|.|.:.:|...|||||||:::|:||.:|..||:::.
  Rat   313 GINQDRLKEKLTSRQMDSKWGG-KSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAME 376

  Fly   445 FQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFT 509
            .....:.||||||.|||.|..|.|||||||:.|||||:.|.:..||.|||.|.:||:....|.:.
  Rat   377 KDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYF 441

  Fly   510 DNQDIIELIEAKSN--GIFTLLD-------------EESKLPK-----PSYSHFTAEVHKSWANH 554
            :|:.:.:|||:|.|  ||.::||             :::.|.|     .|:.||     .||
  Rat   442 NNKIVCDLIESKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHF-----NSW--- 498

  Fly   555 YRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQT 619
                               .:||::.|:||.|.|:.:.|.|:|.|.|...|..|:|..:.|.:::
  Rat   499 -------------------NQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKS 544

  Fly   620 LFPSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQL 684
            |||.......:|:..  :.|||.|.|..:|:..|.:...::|||||||.....:.:|.|....|:
  Rat   545 LFPENLQADKKGRPT--TAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQV 607

  Fly   685 KCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPARTFCEA-----MFQSLNLSAKDF 744
            :..|....:.:...||..|.:|......| ::|..  .:.|.....|.     :.||:|:.:..|
  Rat   608 EYLGLKENIRVRRAGYAYRRVFQKFLQRY-AILTK--ATWPVWRGDEKQGVLHLLQSVNMDSDQF 669

  Fly   745 KFGITKVFFR-PGKFVEFDRIMRSDPENMLAIVAKV-KKWLIRSRWVKSALGA--LCVIKLRNRI 805
            :.|.:|||.: |......:.:.....:....::.|. :|::.|.::|:....|  |.:.|...|
  Rat   670 QLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKTWRKFVARKKYVQMREDASDLLLNKKERR- 733

  Fly   806 IYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIY 870
              ||.   |.:.....::..::|....|.:||..|        |:.|               ||.
  Rat   734 --RNS---INRNFIGDYIGMEEHPELQQFVGKREK--------IDFA---------------DIV 770

  Fly   871 RQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAE 935
            .:.|...|.:|.:..:|.:   .:|.:
  Rat   771 TKYDRRFKGVKRDLLLTPK---CLYLI-------------------------------------- 794

  Fly   936 RAAKEAEEQRQREEIENKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQEQ-----LEKEAKDD 995
              .:|..:|...:.:..:.||.::|..|..:.:....|::     ...|.||     ||...|.:
  Rat   795 --GREKVKQGPDKGLVKEVLKRKIEVERILSVSLSTMQDD-----IFILHEQEYDSLLESVFKTE 852

  Fly   996 ------AKYRQQLEQE---RRDHELALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQV 1051
                  .:|.::.:::   :..:.|.|:|..|:.|...               .|.::.:.|.|.
  Rat   853 FLSLLTKRYEEKTQKQLPLKFSNTLELKLKKENWGPWS---------------AGGSRQVQFYQG 902

  Fly  1052 VSNIA-----SRYLNKSENVRAQQQALGKQKYDLSKWKYSELRDAINTSCDIELLEA---CRQEF 1108
            ..::|     ::.|..|......:.|...::..:|...||   ...|.:..:....|   |.:..
  Rat   903 FGDLAILKPSNKVLQVSIGPGLPKNARPTRRNTVSSRGYS---GGTNNNYPMRAAPAPPGCHRNG 964

  Fly  1109 HRRLKVYHAWKAKNRKRTTMDENERAPRSVMEAAFKQPPLVQPIQEIVTAQHRYFRIP----FMR 1169
            ..|.:..|..:|..        |:|:.:..:..:..:|||  |.|: .|...|..:.|    |::
  Rat   965 LTRNQFVHPPRASG--------NQRSNQKSLYTSMARPPL--PRQQ-STGSDRLSQTPESLDFLK 1018

  Fly  1170 ANAPDNTKRGLWYAHFDGQWIARQMELHADKPP 1202
              .||....|          :.||.   ..:||
  Rat  1019 --VPDQGAAG----------VRRQT---TSRPP 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	254/723 (35%)
		MYSc_Myo6	71..754	CDD:276833	250/712 (35%)
		RILP-like	<968..1015	CDD:304877	10/60 (17%)
		Myosin-VI_CBD	1160..1246	CDD:293129	10/47 (21%)
Myo1e	NP_775124.1	MYSc	14..692	CDD:214580	255/736 (35%)
		MYSc_Myo1	33..679	CDD:276829	250/712 (35%)
		Actin-binding. /evidence=ECO:0000255	581..591		6/9 (67%)
		Myosin_TH1	719..899	CDD:283635	41/271 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	920..1052		28/146 (19%)
		SH3_MyoIe_If_like	1055..1106	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010