Protein Alignment jar and myo2

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_588114.1
• Gene: myo2 / 2539513
• PomBaseID: SPCC645.05C
• Length: 1526
• Species: Schizosaccharomyces pombe
• Alignment Length: 1417
• Identity: 389/1417 - (27%)
• Similarity: 631/1417 - (44%)
• Gaps: 294/1417 - (20%)

  Fly     2 LEDTQLVWVRDAAEGYIQGRITE-----------IGAKEFEVTPTDRKYPKRTCHFDDIHSSCDG 55
            ::|.:.||:.|....:.:..|.|           ..:::.::...|...|.....||.:
pombe    21 IDDKRWVWISDPETAFTKAWIKEDLPDKKYVVRYNNSRDEKIVGEDEIDPVNPAKFDRV------ 79

  Fly    56 PQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSL 120
                :|..||..|||.....||:.||..|:||||....|:|||||..: .:|..|.|:.|..::.
pombe    80 ----NDMAELTYLNEPAVTYNLEQRYLSDQIYTYSGLFLVAVNPYCGL-PIYTKDIIQLYKDKTQ 139

  Fly   121 GELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDS----AGPIETK 181
            ....||||||||.|..::...|.:|||:|:|||||||||:||.:::||.....|    :..:|.:
pombe   140 ERKLPHVFAIADLAYNNLLENKENQSILVTGESGAGKTENTKRIIQYLAAIASSTTVGSSQVEEQ 204

  Fly   182 ILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYH 246
            |:..|||||:||||:|.||||||||||||:|.:....::....|..|||||||:..|:..|||||
pombe   205 IIKTNPVLESFGNARTVRNNNSSRFGKFIKVEFSLSGEISNAAIEWYLLEKSRVVHQNEFERNYH 269

  Fly   247 VFYMLLAGAPQQLRDKLSL-GKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPII 310
            |||.||:||...|::||.| ...:|||||                    |...|...|      :
pombe   270 VFYQLLSGADTALKNKLLLTDNCNDYRYL--------------------KDSVHIIDG------V 308

  Fly   311 DDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEI------------PDDVRGGCQ 363
            ||.:.|..|..|...||..|.|...::::::.:||:|||   ::            ||::...|.
pombe   309 DDKEEFKTLLAAFKTLGFDDKENFDLFNILSIILHMGNI---DVGADRSGIARLLNPDEIDKLCH 370

  Fly   364 V----SEASEQSLT---ITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARD 421
            :    .|...|:|.   |.:|...|.....:|.::|.:                          :
pombe   371 LLGVSPELFSQNLVRPRIKAGHEWVISARSQTQVISSI--------------------------E 409

  Fly   422 ALAKAIYSRLFDRIVGLINQSIPF-QASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFN 485
            |||||||.|.|..:|..:|.|:.. .|.:::||:|||||||.|..|||||.||||.|||||:|||
pombe   410 ALAKAIYERNFGWLVKRLNTSLNHSNAQSYFIGILDIAGFEIFEKNSFEQLCINYTNEKLQQFFN 474

  Fly   486 DNILKNEQELYKREGLNVPEITF-TDNQDIIELIEAKSN--GIFTLLDEESKLPKPSYSHFTAEV 547
            .::...|||.|.:|.:....|.| .|.|..|:||| |:|  ||.:.||||..:||.:.:.||:::
pombe   475 HHMFVLEQEEYMKEEIVWDFIDFGHDLQPTIDLIE-KANPIGILSCLDEECVMPKATDATFTSKL 538

  Fly   548 HKSWANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQEC 612
            ...|.|       :|.:.|..:..  ::||::.|:|..|.|:||.::|||.|.|:.::..|:.:.
pombe   539 DALWRN-------KSLKYKPFKFA--DQGFILTHYAADVPYSTEGWLEKNTDPLNENVAKLLAQS 594

  Fly   613 DNPLLQTLFPSGSST---SVRGKLN---FISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMI 671
            .|..:.|||.....|   :|||:..   |.:|..:.|.||.:||.:......:|||||.||.:..
pombe   595 TNKHVATLFSDYQETETKTVRGRTKKGLFRTVAQRHKEQLNQLMNQFNSTQPHFIRCIVPNEEKK 659

  Fly   672 DRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPARTFCEA---- 732
            ...|...|.|.||:|:|.:..:.:...|:|:|:.|.|....|:.     :..||..|:.|:
pombe   660 MHTFNRPLVLGQLRCNGVLEGIRITRAGFPNRLPFNDFRVRYEI-----MAHLPTGTYVESRRAS 719

  Fly   733 --MFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGA 795
              :.:.|.:....::.|::|:||:.|...|.:       |..:|.:.::
pombe   720 VMILEELKIDEASYRIGVSKIFFKAGVLAELE-------ERRVATLQRL---------------- 761

  Fly   796 LCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRT-----NTLKTIEIASGL 855
              :..|:.||              ||||.||..:.|.:.|..|..::.     |..:|...|...
pombe   762 --MTMLQTRI--------------RGFLQRKIFQKRLKDIQAIKLLQANLQVYNEFRTFPWAKLF 810

  Fly   856 KMGREEIISGVNDIYRQIDDA--------IKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTK 912
            ...|..:.|..||...:..||        :||.:.:....:|::......:.|..|.||.:....
pombe   811 FNLRPLLSSTQNDKQLKKRDAEIIELKYELKKQQNSKSEVERDLVETNNSLTAVENLLTTERAIA 875

  Fly   913 L-KEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEMETR--RKAAEAQRLRQE 974
            | ||:.....||||..|:::..   ..|:..|..|||....|::..|:|:.  .|.::.:.|..|
pombe   876 LDKEEILRRTQERLANIEDSFS---ETKQQNENLQRESASLKQINNELESELLEKTSKVETLLSE 937

  Fly   975 EEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPPVIRNGVNDASP 1039
            :.:      |:|:|..|.||....:.:||..|.::...|....|.|.|.:.....|  ...||
pombe   938 QNE------LKEKLSLEEKDLLDTKGELESLRENNATVLSEKAEFNEQCKSLQETI--VTKDA-- 992

  Fly  1040 MGPNKLISFSQVVSNIAS-----RYLNKSENVRAQQQ--------------------------AL 1073
                :|...::.:|:..:     |..|:..|.::.||                          .|
pombe   993 ----ELDKLTKYISDYKTEIQEMRLTNQKMNEKSIQQEGSLSESLKRVKKLERENSTLISDVSIL 1053

  Fly  1074 GKQKYDLSKWK------YSELRDAIN-TSCDIELLEACRQE---FHRRLKVYHAWKAKNR----- 1123
            .:||.:||..|      .:.|.:.:| ...|::.|...::|   .:.:.::|.....||:
pombe  1054 KQQKEELSVLKGVQELTINNLEEKVNYLEADVKQLPKLKKELESLNDKDQLYQLQATKNKELEAK 1118

  Fly  1124 --------KRTT--MDENERAPRSVMEAAFK-------QPPLVQPIQEIVTAQHRY--FRIPFMR 1169
                    |..|  ::..|...:::.:|:.|       ...|:..:.::...:.:|  .::....
pombe  1119 VKECLNNIKSLTKELENKEEKCQNLSDASLKYIELQEIHENLLLKVSDLENYKKKYEGLQLDLEG 1183

  Fly  1170 ANAPDNTKRGLWYAH----FDGQWIARQMELHADKPPILLVAGTDDMQMCELSLEETGLTR---- 1226
            ....|...:.|...|    |:.:.:.||...:.:|   |.:|.:::.   :||.:.:.||:
pombe  1184 LKDVDTNFQELSKKHRDLTFNHESLLRQSASYKEK---LSLASSENK---DLSNKVSSLTKQVNE 1242

  Fly  1227 -----------KRGAEILEHEFNREWERNGGKAYKNLGAAKPNGPAAAMQKQ 1267
                       :|....|.||:::..:....:..|.|.|::.|....:::.:
pombe  1243 LSPKASKVPELERKITNLMHEYSQLGKTFEDEKRKALIASRDNEELRSLKSE 1294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	9/52 (17%)
		MYSc_Myo6	71..754	CDD:276833	256/722 (35%)
		CBD_MYO6-like	765..913	CDD:409646	30/160 (19%)
		ERM_helical	<954..1020	CDD:466641	16/67 (24%)
		MYO6_MIU_linker	1002..1093	CDD:480843	24/127 (19%)
		MyUb_Myo6	1076..1116	CDD:439319	10/49 (20%)
		Myosin-VI_CBD	1160..1246	CDD:465157	18/106 (17%)
myo2	NP_588114.1	COG5022	6..1516	CDD:227355	389/1417 (27%)