Protein Alignment jar and myo52

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_588492.1
• Gene: myo52 / 2538846
• PomBaseID: SPCC1919.10C
• Length: 1516
• Species: Schizosaccharomyces pombe
• Alignment Length: 1165
• Identity: 340/1165 - (29%)
• Similarity: 553/1165 - (47%)
• Gaps: 188/1165 - (16%)

  Fly     9 WVRDAAEGYIQGRITEI---GAKEF-------------EVTPTDRKYPKRT--CHFDDIHSSCDG 55
            |:.|....:|.|.|.:.   |.|.|             .|.|.|..|..|.  .....|:|
pombe    13 WIPDEQSQWIPGSIKDCRVEGEKAFLTVQDENENETVITVKPDDLNYEGRNGLPFLRSINS---- 73

  Fly    56 PQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSL 120
              |.||..:|..|||.:.||.|.|||.:.:||||...:||||||::.:..||..:.::.|:.:|.
pombe    74 --DADDLTDLSYLNEPSVLDALSTRYNQLQIYTYSGIVLIAVNPFQRLPNLYTHEIVRAYSEKSR 136

  Fly   121 GELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKY------LCYSHDS---AG 176
            .||.||::|||:.:.:.|.....:|:||:|||||||||.|.:|:::|      |..|.||   ..
pombe   137 DELDPHLYAIAEDSYKCMNQEHKNQTIIISGESGAGKTVSARYIMRYFASVQALIQSTDSNFHEA 201

  Fly   177 P----IETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICT 237
            |    :|.:||..||::|||||:||:||:|||||||:|::.:|....::|..|..||||:||:..
pombe   202 PQLTAVENEILATNPIMEAFGNSKTSRNDNSSRFGKYIQILFDGNATIIGAKIQTYLLERSRLVF 266

  Fly   238 QSAEERNYHVFYMLLAGAPQQLRDKLSL-GKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQ 301
            |..:|||||:||.:|||:..:..:|..| ....::.||..     .|..|   |.|
pombe   267 QPNQERNYHIFYQILAGSSSEQLEKWKLVENSQEFNYLKQ-----GNCST---IEG--------- 314

  Fly   302 KGPLKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSE 366
                    ::|.:.|.....||..:|:.:.....|:||:||:||:|||..:...:|    ..:..
pombe   315 --------VNDKEEFKATVDALKTVGIDNDTCECIFSLLAALLHIGNIEVKHSRND----AYIDS 367

  Fly   367 ASEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRL 431
            .:|..:..|| |||||.:.|...|..|.::....|     |:.||..::|..|||::||.:|:.|
pombe   368 KNENLINATS-LLGVDPSSLVKWLTKRKIKMASEG-----ILKPLNEFQAVVARDSVAKFLYASL 426

  Fly   432 FDRIVGLINQSIPF------QASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILK 490
            ||.:|..||:::.:      |.:..:||||||.|||:|..||||||||||.|||||:.|..::.|
pombe   427 FDWLVATINKALMYSADKSNQTAKSFIGVLDIYGFEHFKKNSFEQFCINYANEKLQQEFYRHVFK 491

  Fly   491 NEQELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWA--- 552
            .|||.|..||||...|.:.|||..|.:||::. ||.:|||||.::|..|..::.::::.:::
pombe   492 LEQEEYAAEGLNWSYIDYQDNQQCISMIESRL-GILSLLDEECRMPTNSDENWVSKLNDAFSKPE 555

  Fly   553 --NHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNP 615
              |.|     :.||.       ..:.|.::|:|..|.|..|.||:||.|.:...|..|....|.|
pombe   556 FKNSY-----QKSRF-------GNKEFTIKHYALDVVYCAEGFIDKNRDTISDELLELFTNSDVP 608

  Fly   616 LLQTLF--------PSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMID 672
            .::.|.        |...:..::.|....::||.||:.|..||..:.:...::|||||||.:...
pombe   609 FVKDLVLFRLEQTAPPADTKKIKTKPKSNTLGSMFKSSLVSLMSTINETNAHYIRCIKPNEEKEA 673

  Fly   673 RQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPARTFCEAMFQSL 737
            .:|:..:.::||:..|.:..:::...|:|||..|.:..|.|..::|..:.:..:.||.:|:.:.
pombe   674 WKFDNQMVVSQLRACGVLETIKISCAGFPSRWTFDEFVSRYYMLVPSAVRTTESLTFSKAILEK- 737

  Fly   738 NLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLR 802
            :.....::.|.||:|||.|    ...::.|..:..|...|.:            ...|..|...|
pombe   738 HADPTKYQIGKTKIFFRSG----VTPLLESARDKALKHAAHL------------LYEAFAVNYYR 786

  Fly   803 NRIIYRNKCVLIAQRIARGFLARK--QHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISG 865
            .|.:...|.|...|.:|.|||:|:  ::......|.|:..:....||           |:|.|..
pombe   787 TRFLLSRKRVRSFQAVAHGFLSRRHTEYELLSSNIIKLQSLWRTALK-----------RKEFIQT 840

  Fly   866 VNDIYRQIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQ------------- 917
            .|.|.: :...|:...:...:.::.......::.:..  ||...:...||.|
pombe   841 KNSILK-VQSIIRGFLLRQTLEEKTKHDATLIIQSLW--LTFKAHKHYKELQYYAVRIQSLWRMK 902

  Fly   918 -----------QAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLK---AEMETRRKAAEA 968
                       ::.:...|:::...||:.  ..|..:|....|.||.:.:   ||:|:.......
pombe   903 LAKRQLTELKIESTKASHLKQVSYRLESR--LFEISKQLDNSEQENNKFRERIAELESHLSNYAE 965

  Fly   969 QRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVED-SPPVIRN 1032
            .:|.||.|..:..:.:.:|     ..|.:.::.||::    |.||.:..|...||.| :..::|.
pombe   966 AKLAQERELEQTRVLISDQ-----SQDGELKELLEEK----ENALIMMEEEMRQVNDANTELLRV 1021

  Fly  1033 GVNDASPMGPNKLISFSQ---------VVSNI--ASRYLNKSENVRAQQQALGKQKYDLS 1081
            .....|.:....:|...|         :::::  |::.||.:.::...:.:..|.:.|.|
pombe  1022 NATLKSQLKNYDMIIVEQTSQLKEKNRIIASLTKATKILNSASSIEQSRNSEEKSRRDSS 1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	13/57 (23%)
		MYSc_Myo6	71..754	CDD:276833	249/715 (35%)
		CBD_MYO6-like	765..913	CDD:409646	27/149 (18%)
		ERM_helical	<954..1020	CDD:466641	15/68 (22%)
		MYO6_MIU_linker	1002..1093	CDD:480843	19/92 (21%)
		MyUb_Myo6	1076..1116	CDD:439319	2/6 (33%)
		Myosin-VI_CBD	1160..1246	CDD:465157
myo52	NP_588492.1	COG5022	1..1501	CDD:227355	340/1165 (29%)