Protein Alignment jar and myo7aa

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_073784889.1
• Gene: myo7aa / 252846
• ZFINID: ZDB-GENE-020709-1
• Length: 2232
• Species: Danio rerio
• Alignment Length: 1448
• Identity: 401/1448 - (27%)
• Similarity: 596/1448 - (41%)
• Gaps: 359/1448 - (24%)

  Fly    40 PKRTCHFDDIH-SSCDGPQDHDDNCELMLLNEATFLDNLKTRYYKDKIY------TYVANILIAV 97
            |:...:...:| :|..|.   :|...|..||||..|.||..||.:..||      ||..:||:||
Zfish    79 PQNATNIKPMHPTSIHGV---EDMIRLGDLNEAGILRNLLIRYREHLIYTNCGGRTYTGSILVAV 140

  Fly    98 NPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTK 162
            ||| ::..:|..|.|:.|..:.:||:|||:|||||....:|:.....|..|:|||||||||||||
Zfish   141 NPY-QLLPIYTADQIRLYTNKKIGEMPPHIFAIADNCYFNMQRNNKDQCCIISGESGAGKTESTK 204

  Fly   163 YLLKYLCYSHDSAGPIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISH 227
            .:|::|.........||.::|:|||:|||||||||.||:|||||||:|::|::.:..:.|..|..
Zfish   205 LILQFLAAISGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQ 269

  Fly   228 YLLEKSRICTQSAEERNYHVFYMLLAGAPQQLRDKLSLGKPDDYRYLS--GCTQYFANAKTEQLI 290
            |||||||:|.|:.:|||||:||.:|.|.....:.:|.|.|..||.||:  .||          :.
Zfish   270 YLLEKSRVCRQARDERNYHIFYCMLKGMTPDQKKQLGLSKATDYTYLTIGNCT----------VC 324

  Fly   291 PGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIP 355
            .|.                 ||.:.:.|:..|:..|..:|.|...|..|:||:||:||:.:|...
Zfish   325 DGR-----------------DDQKEYSNIRSAMKVLMFTDKENWEISKLLAAILHMGNLRYEART 372

  Fly   356 DDVRGGCQVSEASEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNAR 420
            .|....|:|...|  :||..:.||.||..:|...|.||.:.:     :|..:..||.|.:|.:.|
Zfish   373 YDNLDACEVVRCS--ALTTAAVLLEVDLKDLMNCLTSRTIIT-----RGETVSTPLSIEQALDVR 430

  Fly   421 DALAKAIYSRLFDRIVGLIN------QSIPFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEK 479
            ||..|.||.|||..||..||      .|:..:|....||:|||.|||.|.||||||.|||:.||.
Zfish   431 DAFVKGIYGRLFVWIVEKINAAIYKPPSLELKAVRRSIGLLDIFGFENFMVNSFEQLCINFANEN 495

  Fly   480 LQKFFNDNILKNEQELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFT 544
            ||:||..::.|.|||.|..|.:|...|.||||||.:::|..|...|.:|:|||||.||.:.:...
Zfish   496 LQQFFVRHVFKLEQEEYNLENINWQHIEFTDNQDALDMIAIKPMNIISLIDEESKFPKGTDTTML 560

  Fly   545 AEV---HKSWANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLE 606
            .::   ||...|:    :|..:..        |..|.::||||.|.|.|..|:|||.|.||..:.
Zfish   561 NKLNSQHKLNTNY----IPPKNTY--------ETQFGIQHFAGVVYYETRGFLEKNRDTLHGDII 613

  Fly   607 GLVQECDNPLLQTLFPS----------------------GSSTSVRGKLNFISVGSKFKTQLGEL 649
            .||....|..::.:|.:                      |:.|..|..    ::.|:||..|..|
Zfish   614 QLVHSSKNKFIKQIFQADVAMFLCGYWSDSLGKAGSLHKGAETRKRSP----TLSSQFKRSLELL 674

  Fly   650 MEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYK 714
            |..|......|:||||||.......|:..|.:.||:.||.:..:.:...|||.|..|.:....|:
Zfish   675 MRTLSVCQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYR 739

  Fly   715 SVLP---PELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFR---------------PGKFVEF 761
            .::|   |.......|..|:.:.:::.....|::.|.||:|.:               ..|.:..
Zfish   740 VLMPGVKPAYKQEDLRGTCQRIAEAVLGRDDDWQMGKTKIFLKDHHDMLLEIERDKAITDKVILI 804

  Fly   762 DRIMR--SDPENMLAIVAKVKK--WLIRSRW----VKSALGALCVIKLRNRIIYRNK-------- 810
            .:::|  .|..|.|    |:||  .||:..|    .:...||:.....|.:.:||::
Zfish   805 QKVVRGFKDRSNFL----KMKKSAMLIQKTWRGYYCRKNYGAMRGGFSRLQALYRSRKLYQTYHV 865

  Fly   811 ---CVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQ 872
               .:::.|...||||.|:..|.|...:           .||:..:...:.|.        :|::
Zfish   866 ARQRIMLFQGRCRGFLVRRAFRHRLWAV-----------ITIQAYTRGMIARR--------LYKR 911

  Fly   873 IDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNT-KLKEQQQAEEQERLRKIQEALEAER 936
            :....::     |:...::.      :|...||...::. |.||:.:...||||.::... :|||
Zfish   912 LKGEYRR-----RLEAEKLR------LAEEQKLRNQMSARKAKEEAEKMHQERLAQLARE-DAER 964

  Fly   937 AAKEAEEQRQREEIENKRLKAEMETRRKA-----------------------------AEAQRLR 972
            ..||.:|.|::.|:.::..||..|....:                             .|.....
Zfish   965 EKKERQEARRKMEMLDQMEKARQEPVNDSDMVDKMFGFLGTTNSFPGQEGQAPAGFEDLERTHRE 1029

  Fly   973 QEEEDRRAALAL-QEQLE-----KEAKDDAKY----------RQQLEQERRDHE----------- 1010
            .|.||...:|.| ::.||     |.||..|.|          |:.|:|....||
Zfish  1030 LEVEDLDESLPLPEDDLEDLSEYKFAKFSATYFQGTSTHTYMRRPLKQPLLFHEDEGDQLAALAV 1094

  Fly  1011 --LALRLANESNGQVEDSP-PVIRNGVNDASPMGP------------------------------ 1042
              ..||.       :.|.| |.....::|.|...|
Zfish  1095 WITVLRF-------MGDLPEPKYHTAISDGSEKIPVMTKIYETLGKKTYKRELQALQGEGENTHI 1152

  Fly  1043 ---------NKLISF-----SQVVSNIASRYLNKSE-NVRAQQQALGKQKYDLSKWKY------- 1085
                     :||:|.     |::...:..| ||..| .|........:...:|.|..:
Zfish  1153 ESHKKSSVRHKLVSLTLKKKSKITEEVTKR-LNDGEYTVHGNSMLEDRPTSNLEKLHFIIGNGIL 1216

  Fly  1086 -SELRDAINTSCDIELLEACRQEFHRRLKVYHA--W--------------KAKNRKRTTMDE--- 1130
             ..|||.|  .|.|     |:|......|..||  |              |.....|..:.|
Zfish  1217 RPGLRDEI--YCQI-----CKQLNQNPSKSSHARGWILMSLCVGCFAPSEKFVKYLRNFISEGPP 1274

  Fly  1131 ------NERAPRSVMEAAFKQPPLVQPIQEIVTAQHRYFRIPFMRANAPDNTKRGLWYAHFDGQW 1189
                  .||..|:.:.....|||....:|...:.:.....:.||     |.|.:.|
Zfish  1275 GYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFM-----DGTTKTL--------- 1325

  Fly  1190 IARQMELHADKPPILLVAGTDDMQMCELSLEETGLTRKRGAEILEHEFNREWERNGGKAY----- 1249
                          |..:.|...::|....::..|..:.|..:....|::......|..:
Zfish  1326 --------------LTDSATTAKELCNALSDKISLQDRFGFSLYIALFDKVSSLGSGNDHVMDAV 1376

  Fly  1250 -------KNLGAAKPNGP 1260
                   |..||.:.|.|
Zfish  1377 SQCEQYAKEQGAQERNAP 1394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	1/8 (13%)
		MYSc_Myo6	71..754	CDD:276833	266/724 (37%)
		CBD_MYO6-like	765..913	CDD:409646	31/167 (19%)
		ERM_helical	<954..1020	CDD:466641	23/123 (19%)
		MYO6_MIU_linker	1002..1093	CDD:480843	26/157 (17%)
		MyUb_Myo6	1076..1116	CDD:439319	11/47 (23%)
		Myosin-VI_CBD	1160..1246	CDD:465157	11/85 (13%)
myo7aa	XP_073784889.1	None