Protein Alignment jar and Myo1g

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_006514763.1
• Gene: Myo1g / 246177
• MGIID: 1927091
• Length: 1039
• Species: Mus musculus
• Alignment Length: 1050
• Identity: 307/1050 - (29%)
• Similarity: 470/1050 - (44%)
• Gaps: 171/1050 - (16%)

  Fly    80 RYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADKAIRDMRVYKLS 144
            ::.|.:||||:..:|::||||:|: .||.|:.|.||.||.|.|.|||::|:|:.|.:.|:.....
Mouse    53 KFEKGRIYTYIGEVLVSVNPYQEL-PLYGPEAIAKYQGRELYERPPHLYAVANAAYKAMKRRSRD 116

  Fly   145 QSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETK-----ILDANPVLEAFGNAKTTRNNNSS 204
            ..|::||||||||||::|::::|:....:.:...|.:     :|.:..||||||||:|.||:|||
Mouse   117 TCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKNVLLKSTCVLEAFGNARTNRNHNSS 181

  Fly   205 RFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLRDKLSLGK-P 268
            ||||::::::|.|...|||:|..|||||||:..|...|||:|.||.||.|:..|....|.|.: |
Mouse   182 RFGKYMDINFDFKGDPVGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDQELQGLHLERNP 246

  Fly   269 DDYRYL---SGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALGRLGLSD 330
            ..|.:.   :|......||.       ....|:||                 .:.:|:..:|.|.
Mouse   247 AVYNFTRQGAGLNMGVHNAL-------DSDEKSHQ-----------------GVMEAMRIIGFSP 287

  Fly   331 TEKLGIYSLVAAVLHLGNIAFEEIPDD--VRGGCQVSEASEQSLTITSGLLGVDQTELRTALVSR 393
            .|...|:.::||:||||||.|.|..::  .:||.:|  |.|..:...:.|....:..:...|::|
Mouse   288 DEVESIHRILAAILHLGNIEFVETEENGPQKGGLEV--ADEALVGYVAKLTATPRDLVLRTLLAR 350

  Fly   394 VMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIP-------FQASNFY 451
            .:.|.|    ..||.....:.|||.||||.|||:|.|||:.:|..||..:.       ....:..
Mouse   351 TVASGG----REVIEKSHTVAEASYARDACAKAMYQRLFEWVVNKINSIMEPRNRDPRCDGKDTV 411

  Fly   452 IGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDIIE 516
            ||||||.|||.|.|||||||||||||||||:.|...|||.|||.|:|||:....|.:.:|..|:|
Mouse   412 IGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGIAWQTIEYFNNATIVE 476

  Fly   517 LIEAKSNGIFTLLDEESKLPKPSYSHF---TAEVHKSWANHYRLGLPRSSR--LKAHRTLRDEEG 576
            |:|....||..:|||......|.....   |.:.|.....||      |||  ....:|:.....
Mouse   477 LVEQPHRGILAVLDEACSTAGPITDRIFLQTLDTHHRHHPHY------SSRQLCPTDKTMEFGRD 535

  Fly   577 FLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVRGKLNFISVGSK 641
            |.::|:||.|.|:.|.||:||.|:|....:.|:....:|.|:.::|.|...........::.|:.
Mouse   536 FQIKHYAGDVTYSVEGFIDKNRDSLFQDFKRLLYNSVDPTLRAMWPDGQQDITEVTKRPLTAGTL 600

  Fly   642 FKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLF 706
            ||..:..|:|.|......::||||||...:..:.:.:....|::..|.:..:.:...|:.||..:
Mouse   601 FKNSMVALVENLASKEPFYVRCIKPNEDKVAGRLDEAHCRHQVEYLGLLENVRVRRAGFASRQPY 665

  Fly   707 ADLYSMYKSVL----PPELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRS 767
            ......||...    |..|:. ..|....|:.:...|.. |..||.:|:|.|
Mouse   666 PRFLLRYKMTCEYTWPNHLLG-SDRDAVSALLEQHGLQG-DVAFGHSKLFIR------------- 715

  Fly   768 DPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRY 832
            .|..::.:...      |:|.:.              ||     ||:.|:..||.||| .|..|.
Mouse   716 SPRTLVTLEQS------RARLIP--------------II-----VLLLQKAWRGTLAR-WHCRRL 754

  Fly   833 QGIGKI------NKIRTNTLKTIEIASGLKMGRE--------------EIISGVNDIYRQIDDAI 877
            :.|..|      :|:|.:   .||:....:..|:              .::....|..|.:....
Mouse   755 RAIYTIMRWFRRHKVRAH---LIELQRRFQAARQPPLYGRDLVWPTPPAVLQPFQDTCRVLFSRW 816

  Fly   878 KKIKMNPRITQREMDSMYTVVMA-----------------NMNKLTVDLNTKLKEQQQAEEQERL 925
            :..::...|...:|..:...|.|                 ..:.|:.|.:........||:.:.|
Mouse   817 RARQLVKNIPPSDMIQIKAKVAAMGALQGLRQDWGCQRAWARDYLSSDTDNPTASHLFAEQLKAL 881

  Fly   926 RK---IQEALEAE--RAAKEAEEQRQREEIENKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQ 985
            |:   ....|.:.  |......:.|.|..:...|...::|..|:....:.:..|.....:..:.:
Mouse   882 REKDGFGSVLFSSHVRKVNRFRKSRDRALLLTDRYLYKLEPGRQYRVMRAVPLEAVTGLSVTSGR 946

  Fly   986 EQ---LEKEAKDD---AKYRQQLEQERRDHELALRLANESNGQ-------VEDSPPVIRNGVNDA 1037
            :|   |..:..||   ..:|.|...:.|..||...||....|:       |.|..|:
Mouse   947 DQLVVLHAQGYDDLVVCLHRSQPPLDNRIGELVGMLAAHCQGEGRTLEVRVSDCIPL-------- 1003

  Fly  1038 SPMGPNKLIS 1047
            |..|..:|||
Mouse  1004 SQRGARRLIS 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	244/700 (35%)
		CBD_MYO6-like	765..913	CDD:409646	30/184 (16%)
		ERM_helical	<954..1020	CDD:466641	15/71 (21%)
		MYO6_MIU_linker	1002..1093	CDD:480843	13/52 (25%)
		MyUb_Myo6	1076..1116	CDD:439319
		Myosin-VI_CBD	1160..1246	CDD:465157
Myo1g	XP_006514763.1	MYSc_Myo1	52..715	CDD:276829	244/700 (35%)
		Myosin_TH1	836..1007	CDD:461801	32/178 (18%)