DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and Myo1h

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001158045.1	Gene:	Myo1h / 231646	MGIID:	1914674	Length:	1022	Species:	Mus musculus

Alignment Length:	1075	Identity:	311/1075 - (28%)
Similarity:	495/1075 - (46%)	Gaps:	185/1075 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 NEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADK 133
            :|:.||:||:.|:.::.||||:..:|::||||:|: .:|....::.|.|.:..||||||:||||.
Mouse    24 SESAFLENLRKRFRENLIYTYIGTLLVSVNPYQEL-GIYTASQMELYQGVNFFELPPHVYAIADN 87

  Fly   134 AIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYL---CYSHDSAGPIETKILDANPVLEAFGNA 195
            |.|.|.....:..|::||||||||||::|.:|:|.   |...:|......::|.:.|||||||||
Mouse    88 AYRMMCSELNNHFILISGESGAGKTEASKKILQYFAVTCPMTESLQIARDRLLLSIPVLEAFGNA 152

  Fly   196 KTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLR 260
            ||.||:|||||||::::.:|.:...|||:|..||:||||:..|:..|||:|:||.||||...:..
Mouse   153 KTLRNDNSSRFGKYMDIQFDFQGVPVGGHIISYLIEKSRVVYQNHGERNFHIFYQLLAGGGSERL 217

  Fly   261 DKLSLGK-PDDYRYLSGCTQYFANAKTEQLIPGSQKSKNH-QQKGPLKDPIIDDYQHFHNLDKAL 323
            ..|.|.: |..|:||                     |:.| .::.|:.|.  :|::   .:..|.
Mouse   218 ASLGLERDPQLYKYL---------------------SQGHCARESPISDK--NDWE---TVCGAF 256

  Fly   324 GRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTELRT 388
            ..:|.::.:...::.::|:||||||:.|:   .|.:|...|.:..|  :...:.||||....|..
Mouse   257 SVIGFTEADLENLFGIIASVLHLGNVCFK---GDKQGCASVPDTHE--IKWIAKLLGVCPAVLLE 316

  Fly   389 ALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPFQ--ASNFY 451
            ||..|.:::     |...::.||.:..:..||||:|||:|.|.|..:|..||.|:..:  .....
Mouse   317 ALTHRKIEA-----KTEEVICPLTVELSVYARDAMAKAVYGRTFTWLVNRINSSLVNKDFTQKTV 376

  Fly   452 IGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQDIIE 516
            ||:|||.|||.|..|.||||||||||||||:...:..||.||..|:.||:....:.:.:|:.|.:
Mouse   377 IGLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYESEGIEWETVQYFNNKIICD 441

  Fly   517 LIEAKSNGIFTLLDEESKLPKPSYS-HFTAEVHKSWANHYRLGLPRSSRLKAH---RTLRDEEG- 576
            |:|.:..||.::||||...|.|:.. .|..::.:....|            ||   |.|...:|
Mouse   442 LVEERHRGIISILDEECIRPGPATDLSFLEKLEEKVGKH------------AHFQTRKLAGPKGR 494

  Fly   577 -------FLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVRGKLN 634
                   |.:.|:||.|.|.|:.|:|||||.|:..|:.::....|.:|:..|   ....:..:..
Mouse   495 KRIGWLEFCLLHYAGEVTYCTKGFLEKNNDLLYRHLKEVLCSSKNSILRECF---LVAELENRRR 556

  Fly   635 FISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHG 699
            ..:||::||..|..|:|.|.....::|||||||.:....:|:..|...|:|..|.:..|.:...|
Mouse   557 PPTVGTQFKNSLSSLLEILISKEPSYIRCIKPNERKEPSKFDDFLISHQIKYLGLMEHLRVRRAG 621

  Fly   700 YPSRVLFADLYSMYKSVLP---PELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGK--FV 759
            :..|..:......|||:.|   |.....|... .|.:.:.:....:|:|.|.||:|.|..:  |.
Mouse   622 FAYRRKYEHFLQRYKSLCPDTWPHWHGPPGEG-VERLIKYIGYQPQDYKLGKTKIFIRFPRTLFA 685

  Fly   760 EFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCV------IKLRNRIIYRNKCVLIAQRI 818
            ..|....|..:.:..|.|..|..|.|..::|....|..:      :..|..|..|...|.|.:|.
Mouse   686 TEDAFEFSKHQLVSRIQATYKGCLGRREYMKKRQAATKLEAHWRGVLARKEIKRRRWAVQIIRRF 750

  Fly   819 ARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKIKMN 883
            .:||:.|  .:|                        |....||.:..|...|        .:.:.
Mouse   751 VKGFINR--DKP------------------------LCPDNEEFVVLVRKNY--------ILNLR 781

  Fly   884 PRITQREMDSMY---TVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQR 945
            ..:.:..:|..:   ..::.|.:.|...:.|:          ..:||....:.|||.|.
Mouse   782 YHVPKNVLDKSWLRPPGILENASNLLRRMCTR----------NLVRKYCRGISAERKAM------ 830

  Fly   946 QREEIENKRLKAEMETRRKAAEAQRLRQ-------EEE------------------------DRR 979
                ::.|.:.:|:...:|...|:.|.|       :|.                        ||:
Mouse   831 ----MQQKVVTSEIFRGKKEGYAESLNQLFAGSRLDESNINPKVLQLLGSEKIQYGVPVIKYDRK 891

  Fly   980 AALALQEQL---EKEAKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPPVIRNGVNDASPMG 1041
            ...|.|.||   ::.|     |..:|.:.::..|.| .:...|...:.|...||.  ::.|....
Mouse   892 GFKARQRQLLLTQRSA-----YLVELSKVKQKIEYA-AVRGVSTSSLSDGILVIH--ISPADKQQ 948

  Fly  1042 PNKLISFSQVVSNIASR---YLNKSENVRAQQQAL 1073
            ...:|...:.:..:|::   .:.|...||..|.:|
Mouse   949 KGDVILQCEHIFEVATKLAMLIRKEHTVRVVQGSL 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	245/706 (35%)
		MYSc_Myo6	71..754	CDD:276833	244/704 (35%)
		RILP-like	<968..1015	CDD:304877	15/80 (19%)
		Myosin-VI_CBD	1160..1246	CDD:293129
Myo1h	NP_001158045.1	MYSc	8..689	CDD:214580	247/717 (34%)
		MYSc_Myo1	26..678	CDD:276829	244/704 (35%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	568..590		10/21 (48%)
		Myosin_TH1	834..1001	CDD:283635	30/158 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010