DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment jar and MYO16

DIOPT Version :10

Sequence 1:NP_001014650.2 Gene:jar / 42889 FlyBaseID:FBgn0011225 Length:1268 Species:Drosophila melanogaster
Sequence 2:NP_001185879.1 Gene:MYO16 / 23026 HGNCID:29822 Length:1880 Species:Homo sapiens


Alignment Length:932 Identity:256/932 - (27%)
Similarity:421/932 - (45%) Gaps:201/932 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 PQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKY---NG 117
            |..:||...|..||:.:.|..::.|:..::|||::.:||:.||||:|: .:|:....:.|   :|
Human   422 PAPNDDLATLSELNDGSLLYEIQKRFGNNQIYTFIGDILLLVNPYKEL-PIYSSMVSQLYFSSSG 485

  Fly   118 RSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYL-CYSHDSAGPIETK 181
            :....||||:|:..::|...:...:..|..|:|||.|:||:|::|.::::| |.:..|...::::
Human   486 KLCSSLPPHLFSCVERAFHQLFREQRPQCFILSGERGSGKSEASKQIIRHLTCRAGASRATLDSR 550

  Fly   182 ILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHY-DAKCQVVGGYISHYLLEKSRICTQSAEERNY 245
            ......:|||||:||||.|:.||.|.|:.|:.: :.|.|:.|..|..|||||||:.:|...:.|:
Human   551 FKHVVCILEAFGHAKTTLNDLSSCFIKYFELQFCERKQQLTGARIYTYLLEKSRLVSQPLGQSNF 615

  Fly   246 HVFYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPII 310
            .:||:|:.|...:.:..|.|.....:|||:...|..|:.        .::|.|.::...||    
Human   616 LIFYLLMDGLSAEEKYGLHLNNLCAHRYLNQTIQDDAST--------GERSLNREKLAVLK---- 668

  Fly   311 DDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTIT 375
                      :||..:|.|..|...::.::||:||||:|.|..:.:    |.....:..|.|...
Human   669 ----------RALNVVGFSSLEVENLFVILAAILHLGDIRFTALNE----GNSAFVSDLQLLEQV 719

  Fly   376 SGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLIN 440
            :|:|.|...||.:||.:.:..     |||.:|:....|..|...||.|||::|||||..:|..:|
Human   720 AGMLQVSTDELASALTTDIQY-----FKGDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMN 779

  Fly   441 QSIPFQ-----ASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREG 500
            ..:..|     .....||:|||.|||.|..|.|||.|:|..|||:..:.|:.:..:||....:||
Human   780 SCLHSQDEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEG 844

  Fly   501 LNVPEITFTDNQD-IIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSR 564
            :.:.......||: :::....|.:|..|||||||::.....|:|..::.         .|..||.
Human   845 VTMETAYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQ---------SLLESSN 900

  Fly   565 LKA-HRTLRDEEG----------FLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQ 618
            ..| :..::|..|          |.:.|:||.|.|:....||||.|:|..:|..:::..:|.::.
Human   901 TNAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVIN 965

  Fly   619 TLFPS-----GSSTSVRGKLNF------------------------------------------- 635
            .||.|     ||..|......|                                           
Human   966 HLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQRL 1030

  Fly   636 -----ISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLEL 695
                 :::.|:.:..|.:::.||::...:||.||:||:..:...|:.....|||:..|.:.::::
Human  1031 ERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKI 1095

  Fly   696 MEHGYPSRVLFADLYSMYKSVLPPELVSLPARTF------------CEAMFQSLNLSAKDFKFGI 748
            ..:|||.|:.|:|..|.||.:         |.||            |..:.|...|  :.::.|:
Human  1096 FRYGYPVRLSFSDFLSRYKPL---------ADTFLREKKEQSAAERCRLVLQQCKL--QGWQMGV 1149

  Fly   749 TKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVL 813
            .|||.:                                .|....|..|| ::|:.:||       
Human  1150 RKVFLK--------------------------------YWHADQLNDLC-LQLQRKII------- 1174

  Fly   814 IAQRIARGFLARKQH-----RPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQI 873
            ..|::.|||||| ||     ..|.|.:..||....||..     .|||.....:|...:||.|: 
Human  1175 TCQKVIRGFLAR-QHLLQRISIRQQEVTSINSFLQNTED-----MGLKTYDALVIQNASDIARE- 1232

  Fly   874 DDAIKKIKMNPRITQREMDSMY 895
                     |.|: :.||::.|
Human  1233 ---------NDRL-RSEMNAPY 1244

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
jarNP_001014650.2 Myosin_N 7..49 CDD:460670
MYSc_Myo6 71..754 CDD:276833 216/769 (28%)
CBD_MYO6-like 765..913 CDD:409646 34/136 (25%)
ERM_helical <954..1020 CDD:466641
MYO6_MIU_linker 1002..1093 CDD:480843
MyUb_Myo6 1076..1116 CDD:439319
Myosin-VI_CBD 1160..1246 CDD:465157
MYO16NP_001185879.1 ANKYR 67..347 CDD:440430
ANK repeat 86..112 CDD:293786
ANK repeat 114..145 CDD:293786
ANK repeat 147..178 CDD:293786
ANK repeat 180..210 CDD:293786
ANK repeat 243..274 CDD:293786
ANK repeat 276..307 CDD:293786
ANK repeat 309..335 CDD:293786
MYSc_Myo16 437..1155 CDD:276844 216/769 (28%)
NYAP_N 1243..1590 CDD:464717 1/2 (50%)
NYAP_C 1652..1880 CDD:464724
Blue background indicates that the domain is not in the aligned region.

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