Protein Alignment jar and myo-2

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_510092.2
• Gene: myo-2 / 181404
• WormBaseID: WBGene00003514
• Length: 1947
• Species: Caenorhabditis elegans
• Alignment Length: 1401
• Identity: 373/1401 - (26%)
• Similarity: 606/1401 - (43%)
• Gaps: 309/1401 - (22%)

  Fly     1 MLED-------TQLVWVRDAAEGYIQGRITEIGAKEFEVTPTDRKYPKRTCHFDDIHSSCDGP-- 56
            ||:|       .:.||:.|:.:|||:|.||:....  .||.:..:..::|.. .|:....:.|
 Worm    19 MLQDQSRAYDSKKNVWIPDSEDGYIEGVITKTAGD--NVTVSIGQGAEKTVK-KDVVQEMNPPKF 80

  Fly    57 QDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLG 121
            :..:|...|..||:|:.|.|||.||....||||.....:.:|||:.: .:|.....:.:.|:...
 Worm    81 EKTEDMSNLTFLNDASVLYNLKARYAAMLIYTYSGLFCVVINPYKRL-PIYTDSVARMFMGKRRT 144

  Fly   122 ELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYL----CYSHDSAG------ 176
            |:|||:||::|:|.|:|.....:||::::|||||||||:||.::.|.    ....::.|
 Worm   145 EMPPHLFAVSDEAYRNMLQNHENQSMLITGESGAGKTENTKKVISYFAAVGAAQQETFGAKKAAT 209

  Fly   177 ---------PIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEK 232
                     .:|.:|:..||||||||||||.||||||||||||.:|:..:.:|....|.||||||
 Worm   210 EEDKNKKKVTLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQGRVASCDIEHYLLEK 274

  Fly   233 SRICTQSAEERNYHVFYMLLAGAPQQLRDKLSLGKP-DDYRYLSGCTQYFANAKTEQLIPGSQKS 296
            ||:..|:..||.||:||.:.:.....|:..|.|.|| .||.::         |:.|.:|.|....
 Worm   275 SRVIRQAPGERCYHIFYQVFSDYLPNLKKDLLLNKPVKDYWFI---------AQAELIIDGINDK 330

  Fly   297 KNHQQKGPLKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGG 361
            :.||.                 .|:|...|..:.|||:..|.||||::|:||:.|::.|.:.:..
 Worm   331 EEHQL-----------------TDEAFDILKFTPTEKMECYRLVAAMMHMGNMKFKQRPREEQAE 378

  Fly   362 CQVSEASEQSLTITSGLLGVDQTELRTALV-SRVMQSKGGGFKGTVIMVPLKIYEASNARDALAK 425
            ...::.:|::    :...|:|..|...||. .||........||.      .|.:.:.|..|:||
 Worm   379 PDGTDDAERA----AKCFGIDSEEFLKALTRPRVKVGNEWVNKGQ------NIEQVNWAVGAMAK 433

  Fly   426 AIYSRLFDRIVGLINQSIPFQ--ASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNI 488
            .:|||:|:.:|...||::..:  :.:.:||||||||||.|..|||||..||:.|||||:|||.::
 Worm   434 GLYSRIFNWLVKKCNQTLDQKGISRDHFIGVLDIAGFEIFDFNSFEQLWINFVNEKLQQFFNHHM 498

  Fly   489 LKNEQELYKREGLNVPEITF-TDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAE-VHKSW 551
            ...|||.|.|||:....|.| .|.|..||||| |..||..:||||..:||.:......: :.:..
 Worm   499 FVLEQEEYAREGIQWTFIDFGLDLQACIELIE-KPLGIIAMLDEECIVPKATDLTLAQKLIDQHL 562

  Fly   552 ANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPL 616
            ..|     |...:.|..:..:.|..|.:||:||.|.||...::|||.|.|:.::..:::......
 Worm   563 GKH-----PNFEKPKPPKGKQAEAHFAMRHYAGTVRYNCLNWLEKNKDPLNDTVVTVMKASKEHA 622

  Fly   617 L-------QTLFPSGSSTSVRGKL---------NFISVGSKFKTQLGELMEKLEQNGTNFIRCIK 665
            |       .|.....::.:.:|..         :|::|...::..|.:||..|.....:|||||.
 Worm   623 LIVEVWQDYTTQEEAAAAAAKGTAGAKKKGKSGSFMTVSMLYRESLNKLMTMLHSTHPHFIRCII 687

  Fly   666 PNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPART-- 728
            ||.|......:..|.|.||.|:|.:..:.:...|:|:|.|..|....|..:...|  |:..:|
 Worm   688 PNEKKASGVIDAGLVLNQLTCNGVLEGIRICRKGFPNRTLHPDFVQRYALLAADE--SIIGKTDA 750

  Fly   729 ------FCEAMFQSLNLSAKDFKFGITKVFFRPG--------------------------KFVEF 761
                  ....:.:...|..::|:.|:|||||:.|                          .:...
 Worm   751 KKGSALMLARLVKEKKLEEENFRVGLTKVFFKAGIVAHLEDLRDQSLAQLITGLQAQIRWYYQTI 815

  Fly   762 DRIMRSDPENMLAIVAK-VKKWLIRSRWVKSAL----------GAL---------CVIKLRNRII 806
            :|..|.:....|.|:.: ::.|.....||...|          |.:         .|..|::.::
 Worm   816 ERKRRVEKITALKIIQRNIRSWAELRTWVWFKLYGKVKPLVNSGKIEAQYEKLQETVATLKDTVV 880

  Fly   807 YRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVND--- 868
            ..                .::.|...:|..::||...:.|..:|.:.|.....||.::.:|:
 Worm   881 QE----------------EEKKRQLQEGAERLNKETADLLAQLEASKGSTREVEERMTAMNEQKV 929

  Fly   869 -IYRQIDDAIKKIK-------------------------------MNPRITQREMDSMYTVVMA- 900
             :..::.||.||::                               ::.|..:.|.::....:.|
 Worm   930 ALEGKLADASKKLEVEEARAVEINKQKKLVEAECADLKKNCQDVDLSLRKVEAEKNAKEHQIRAL 994

  Fly   901 ---------NMNKLT------VDLNTKLKEQQQAEEQERL------RKIQEALEAERAAKEAEEQ 944
                     |::||.      .:.|.||.|..||.|::.|      .|:.::||......|.|::
 Worm   995 QDEMRQQDENISKLNKERKNQEEQNKKLTEDLQAAEEQNLAANKLKAKLMQSLEDSEQTMEREKR 1059

  Fly   945 RQREEIENKR-----LKAEMET---------------RRKAAEAQRLRQEEEDRRAALA------ 983
            .:.:..:|||     ||...||               |||..|...|..:.||.:||:|
 Worm  1060 NRADMDKNKRKAEGELKIAQETLEELNKSKSDAENALRRKETELHTLGMKLEDEQAAVAKLQKGI 1124

  Fly   984 ---------LQEQL--EKEAKDDAKYRQQLEQERRDHELALRLANESN--------GQVEDSP-P 1028
                     |.:||  ||:|:..|. |.:.:|:....||..:|.:::.        |:.:|:. .
 Worm  1125 QQDEARVKDLHDQLADEKDARQRAD-RSRADQQAEYDELTEQLEDQARATAAQIELGKKKDAELT 1188

  Fly  1029 VIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQKYDLSKWKYSELRDAIN 1093
            .:|..:.::.       :.|.:.::.:..:..:..:.:..|.:.|.|||..:.|.|....|:...
 Worm  1189 KLRRDLEESG-------LKFGEQLTVLKKKGSDAIQELSDQIEQLQKQKGRIEKEKGHMQREFDE 1246

  Fly  1094 TSCDIELLEACRQEFHRRLKVYHA------WKAKNRKRTTMD----------ENERAPRSVMEAA 1142
            :|..::.....|.:..|..|.|..      .||..:.|...|          ||....|.|.|..
 Worm  1247 SSAALDQEAKLRADQERIAKGYEVRLLELRLKADEQSRQLQDFVSSKGRLNSENSDLARQVEELE 1311

  Fly  1143 FKQPPLVQPIQEIVTAQHRYFRIPFMRANAPDNTKR 1178
            .|           :.|.:| .::.|  :|..|:.||
 Worm  1312 AK-----------IQAANR-LKLQF--SNELDHAKR 1333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	12/41 (29%)
		MYSc_Myo6	71..754	CDD:276833	243/731 (33%)
		CBD_MYO6-like	765..913	CDD:409646	31/218 (14%)
		ERM_helical	<954..1020	CDD:466641	27/102 (26%)
		MYO6_MIU_linker	1002..1093	CDD:480843	16/99 (16%)
		MyUb_Myo6	1076..1116	CDD:439319	9/39 (23%)
		Myosin-VI_CBD	1160..1246	CDD:465157	6/19 (32%)
myo-2	NP_510092.2	COG5022	27..1478	CDD:227355	370/1393 (27%)
		MYSc_class_II	95..782	CDD:276951	243/731 (33%)
		SMC_prok_B	1097..1936	CDD:274008	56/259 (22%)