Protein Alignment jar and myo-3

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_506065.2
• Gene: myo-3 / 179676
• WormBaseID: WBGene00003515
• Length: 1969
• Species: Caenorhabditis elegans
• Alignment Length: 1521
• Identity: 397/1521 - (26%)
• Similarity: 641/1521 - (42%)
• Gaps: 348/1521 - (22%)

  Fly     9 WVRDAAEGYIQG--------RITEIGAKEFEVTPTDRKYPKRTCH------FDDIHSSCDGPQDH 59
            |:.|..:|::..        ::|.:..|..::|     ..|..|.      ||..
 Worm    39 WIPDPEDGFVAAEIQSTTGEQVTVVTVKGNQIT-----VKKDQCQEMNPPKFDKT---------- 88

  Fly    60 DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELP 124
            :|...|..||||:.|.|||.||....||||.....:.:|||:.: .:|:...||.:.|:...|:|
 Worm    89 EDMANLTFLNEASVLGNLKDRYKDLMIYTYSGLFCVVINPYKRL-PIYSESVIKHFMGKRRNEMP 152

  Fly   125 PHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY-------------SHDSAG 176
            ||:||::|:|.|:|...|.:||::::|||||||||:||.::.|...             .....|
 Worm   153 PHLFAVSDEAYRNMVQDKENQSMLITGESGAGKTENTKKVISYFAIVGATQAASGKEAKDGKKGG 217

  Fly   177 PIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAE 241
            .:|.:|:..||||||||||||.||||||||||||..|:....::.||.|.||||||||:..|:..
 Worm   218 TLEEQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRTHFSGSGKLAGGDIEHYLLEKSRVVRQAPG 282

  Fly   242 ERNYHVFYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLK 306
            ||.||:||.:::|....||.||.|.  :|..|...|:|      .|..|.|
 Worm   283 ERCYHIFYQIMSGNDPSLRGKLKLS--NDITYYHFCSQ------AELTIEG-------------- 325

  Fly   307 DPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQS 371
               :||.:......:|...:|..|.|.:.:|...|.::|:|.:.|::.|.:.    |.....|:.
 Worm   326 ---MDDKEEMRLTQEAFDIMGFEDNETMDLYRSTAGIMHMGEMKFKQRPREE----QAEPDGEED 383

  Fly   372 LTITSGLLGVDQTELRTALVS-RVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRI 435
            ....:.:||:...|...||.. ||........||.      .:.:.:.|...||||||:|:|..|
 Worm   384 ALNAAAMLGIQAEEFLKALTKPRVRVGTEWVNKGQ------NLEQVNWAVSGLAKAIYARMFKWI 442

  Fly   436 VGLINQSIPFQ--ASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKR 498
            :...|:::..:  ....:||||||||||.|.:|||||..||:.||:||:|||.::...|||.|||
 Worm   443 ITRCNKTLDAKEIERKHFIGVLDIAGFEIFDLNSFEQLWINFVNERLQQFFNHHMFVLEQEEYKR 507

  Fly   499 EGLNVPEITF-TDNQDIIELIEAKSNGIFTLLDEESKLPKP---SYSHFTAEVHKSWANHYRLGL 559
            ||:....|.| .|.|..||||| |..||.::||||..:||.   :|:....:.|        ||.
 Worm   508 EGIAWTFIDFGLDLQACIELIE-KPLGIISILDEECIVPKATDMTYAQKLLDQH--------LGK 563

  Fly   560 -PRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQ-ECDNPLL----- 617
             |...:.|..:..:.:..|.:.|:||.|.||...|:|||.|.|:.:...|:: ..||.|:
 Worm   564 HPNFQKPKPPKGKQGDAHFAIVHYAGTVRYNATNFLEKNKDPLNDTAVALLKHSTDNSLMLDIWQ 628

  Fly   618 --QTLFPSGSSTSV-------RGK-LNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMID 672
              ||...:..:...       ||| .:|.:|...::..|..||..|.|...:|||||.||.|...
 Worm   629 DYQTQEEAAEAAKAGQTAGGKRGKSSSFATVSMIYRESLNNLMNMLYQTHPHFIRCIIPNEKKAS 693

  Fly   673 RQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELV--SLPART---FCEA 732
            ...:.:|.|.||.|:|.:..:.:...|:|:|:|:.|....| ::|..:..  |.|.:.   ..:.
 Worm   694 GVIDSALVLNQLTCNGVLEGIRICRKGFPNRMLYPDFKHRY-AILAADAAKESDPKKASVGILDK 757

  Fly   733 MFQSLNLSAKDFKFGITKVFFRPGKFVEFD--------RIM------------------RSDPEN 771
            :....||:.::||.|.||:||:.|...:.:        ||:                  |.:.:.
 Worm   758 ISVDGNLTDEEFKVGETKIFFKAGVLAKLEDLRDEILSRIVTMFQSRIRSYLAKAEVRRRYEQQT 822

  Fly   772 MLAIVAK-VKKWLIRSRW--------VK---------SALGALCVIKLRNRIIYRNKCVLIAQRI 818
            .|.:|.: |:.|.....|        ||         .|:|.|.|           |...:.:.:
 Worm   823 GLLVVQRNVRAWCTLRTWEWFKLFGKVKPMLKAGKEQEAMGELAV-----------KIQKLEEAV 876

  Fly   819 ARGFLARKQHRPRYQGIGK--------INKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDD 875
            .||.:||.|...:...:.:        :...:.|.....|....|...:..:.|.::||..|::|
 Worm   877 QRGEIARSQLESQVADLVEEKNALFLSLETEKANLADAEERNEKLNQLKATLESKLSDITGQLED 941

  Fly   876 A------------------------IKKIKMNPRITQREMDSMYTVV------MANMNKLTVDL- 909
            .                        ::.::::.|..::|..|....:      |||.::....|
 Worm   942 MQERNEDLARQKKKTDQELSDTKKHVQDLELSLRKAEQEKQSRDHNIRSLQDEMANQDEAVAKLN 1006

  Fly   910 ---------NTKLKEQQQAEEQE--RLRKIQEALEAERAAKEA---EEQRQREEIENKRLKAEME 960
                     |.||.|..|:||.:  .|.||:..||.:....|.   .|:|.|.:||..:.|.|.:
 Worm  1007 KEKKHQEESNRKLNEDLQSEEDKVNHLEKIRNKLEQQMDELEENIDREKRSRGDIEKAKRKVEGD 1071

  Fly   961 -----------TRRKAAEAQRLRQEEED---RRAALA--------LQEQLEKEAKDDAKYRQQLE 1003
                       |::|......|:::|||   ..|.||        ||..:::....:|:..::||
 Worm  1072 LKVAQENIDEITKQKHDVETTLKRKEEDLHHTNAKLAENNSIIAKLQRLIKELTARNAELEEELE 1136

  Fly  1004 QERRDHELALRLANESNGQVED-SPPVIRNGVNDASPMGPNK----------------LISFSQV 1051
            .||...:.:.|..:|:..::|: :..:.:.|...|:.:..||                .::....
 Worm  1137 AERNSRQKSDRSRSEAERELEELTERLEQQGGATAAQLEANKKREAEIAKLRREKEEDSLNHETA 1201

  Fly  1052 VSNIASRY----------LNKSENVRAQQQA-LGKQKYDLSKWKYS---------ELRDAINTSC 1096
            :|::..|:          |...:.::|:.:| ..|.:.||.:.:::         :|..|:.|
 Worm  1202 ISSLRKRHGDSVAELTEQLETLQKLKAKSEAEKSKLQRDLEESQHATDSEVRSRQDLEKALKT-- 1264

  Fly  1097 DIEL----LEACRQEFHRRLKVYHAWKAK--------NRKRTTMD-------------------- 1129
             ||:    |:....|..|:|:.:.|.|.:        ||....||
 Worm  1265 -IEVQYSELQTKADEQSRQLQDFAALKNRLNNENSDLNRSLEEMDNQLNSLHRLKSTLQSQLDET 1328

  Fly  1130 ----ENERAPRSVMEAAFKQPPLVQPIQEIVTAQHRYFRIPFMRANAPDNTKRGLWYAHFDGQWI 1190
                :.|...|..:.|..|.......|......:....:....|..:..|.:...|.|.||.:.:
 Worm  1329 RRNYDEESRERQALAATAKNLEHENTILREHLDEEAESKADLTRQISKLNAEIQQWKARFDSEGL 1393

  Fly  1191 ARQMELHADKPPILL----VAGTDDMQMCELSLEE-------------TGLTRKRGAEILEHEFN 1238
            .:..|:.|.|..:.|    :..|::....:::.:|             .....|..|::..:|.:
 Worm  1394 NKLEEIEAAKKALQLKVQELTDTNEGLFAKIASQEKVRFKLMQDLDDAQSDVEKAAAQVAFYEKH 1458

  Fly  1239 R--------EWERNGGKAYKNLGAAK 1256
            |        ||::........|.||:
 Worm  1459 RRQFESIIAEWKKKTDDLSSELDAAQ 1484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/53 (19%)
		MYSc_Myo6	71..754	CDD:276833	253/724 (35%)
		CBD_MYO6-like	765..913	CDD:409646	34/231 (15%)
		ERM_helical	<954..1020	CDD:466641	20/87 (23%)
		MYO6_MIU_linker	1002..1093	CDD:480843	21/127 (17%)
		MyUb_Myo6	1076..1116	CDD:439319	11/52 (21%)
		Myosin-VI_CBD	1160..1246	CDD:465157	18/110 (16%)
myo-3	NP_506065.2	COG5022	32..1420	CDD:227355	387/1455 (27%)
		MYSc_class_II	100..779	CDD:276951	253/724 (35%)
		SMC_prok_B	1182..1933	CDD:274008	49/306 (16%)